Results 131 to 140 of about 49,899 (288)

Translational Macrophage Mechano‐Immunotherapy for Next‐Generation Implantable Biomaterials

Advanced NanoBiomed Research, EarlyView.
This review explores how macrophage mechanosensing drives inflammation, fibrosis and foreign body responses to implanted biomaterials. It examines emerging pharmacological strategies to modulate mechanotransduction, alongside biomaterial platforms for localised drug delivery, clinical translation, regulatory considerations and standardised testing ...
Xueying Xu, Ian L. Chin, Richard P. Tan
wiley   +1 more source

Age-associated differences in the breast cancer immune microenvironment. [PDF]

J Pathol Clin Res
Abstract Young age is associated with poorer outcomes and more aggressive clinicopathological features in breast cancer, but the biological underpinnings are incompletely understood. With the emergence of infiltrating immune cell tissue‐based biomarkers, we aimed to investigate a relation to age by mapping of CD45, CD3, CD8, FOXP3, and CD163 positive ...
Humlevik RO, Chen Y, Klingen TA, Sæle AK, Svanøe AA, Hugaas U, Kvamme AB, Tegnander AF, Winge I, Aas T, Heie A, Akslen LA, Wik E, Hoivik EA.   +13 more
europepmc   +2 more sources

Functional expression of the CD163 scavenger receptor on acute myeloid leukemia cells of monocytic lineage.

, 2006
The hemoglobin-haptoglobin (Hb-Hp) scavenger receptor CD163 is a monocyte/macrophage-restricted surface antigen, whose expression is strongly up-regulated by glucocorticoids. We have previously shown that CD163 is expressed by acute myeloid leukemia (AML)
Fehr J, Schaer DJ, Bächli EB, Walter RB, Schoedon G   +4 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Prognostic Implication of M2 Macrophages Are Determined by the Proportional Balance of Tumor Associated Macrophages and Tumor Infiltrating Lymphocytes in Microsatellite-Unstable Gastric Carcinoma.

PLoS ONE, 2015
Tumor associated macrophages are major inflammatory cells that play an important role in the tumor microenvironment. In this study, we investigated the prognostic significance of tumor associated macrophages (TAMs) in MSI-high gastric cancers using ...
Kyung-Ju Kim, Xian-Yu Wen, Han Kwang Yang, Woo Ho Kim, Gyeong Hoon Kang   +4 more
doaj   +1 more source

MiniSdd7‐Derived Cytosine Base Editor Promotes Efficient Multiplex Gene Knockout in Porcine Primary Fibroblasts

Animal Research and One Health, EarlyView.
The miniSdd7‐BE4max‐SpG system enables highly efficient multiplex C‐to‐T base editing of APN, CD163, and MSTN in porcine fibroblasts, providing a robust platform for future development of multiplex gene‐edited livestock. ABSTRACT Efficient multiplex genome editing is essential for improving complex traits in livestock that are governed by multiple ...
Shaoshuai Wang, Yu Wang, Dengfeng Bi, Jianguo Zhao, Yanfang Wang   +4 more
wiley   +1 more source

Cloning and expression of porcine CD163 Its use for characterization of monoclonal antibodies to porcine CD163 and development of an ELISA to measure soluble CD163 in biological fluids

, 2023
Peer ...
Pérez, Carlos, Ortuño, E., Gómez, Nuria, García-Briones, M. M., Álvarez, Belén, Martínez De la Riva, Paloma, Alonso, Frank, Revilla Calvo, Concepción, Domínguez, Javier, Ezquerra Martínez, Ángel   +9 more
openaire   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

Increased CD163+cells/CD68+ cells ratio in IBD tissue.

, 2013
A. Representative photomicrographs (100× original magnification) in serial paraffin-embedded sections of surgical samples taken from 1 CTR, 1 patient with UC and 1 patient with CD and stained with CD163 or CD68.
Roberta Caruso (438408), Alfredo Colantoni (438413), Livia Biancone (288349), Daniela De Nitto (438412), Ivan Monteleone (288334), Francesco Pallone (288353), Maria Laura Cupi (438410), Francesca Zorzi (288332), Giovanni Monteleone (288355), Flavio Caprioli (438411), Massimiliano Sarra (288336), Carmine Stolfi (438409), Eleonora Franzè (438407)   +12 more
core   +1 more source