Results 121 to 130 of about 49,899 (288)

Tumor Microenvironment Modulation by Tumor-Associated Macrophages: Implications for Neoadjuvant Chemotherapy Response in Breast Cancer

Breast Cancer: Targets and Therapy
Gizem Oner,1– 3 Marleen Marguerite Praet,4 Hans Stoop,4 Gayathri R Devi,5 Nuh Zafer Canturk,3 Sevilay Altintas,1,2 Christophe Van Berckelaer,1,2 Zwi Berneman,6 Wiebren Tjalma,1,2 Senada Koljenovic,4 Peter A van Dam1,2 1Multidisciplinary Oncologic Centre ...
Oner G, Praet MM, Stoop H, Devi GR, Canturk NZ, Altintas S, Van Berckelaer C, Berneman Z, Tjalma W, Koljenovic S, van Dam PA   +10 more
doaj  

Structural basis for inflammation-driven shedding of CD163 ectodomain and tumor necrosis factor-α in macrophages

, 2014
The haptoglobin-hemoglobin receptor CD163 and proTNF-α are transmembrane macrophage proteins subjected to cleavage by the inflammation-responsive protease ADAM17. This leads to release of soluble CD163 (sCD163) and bioactive TNF-α. Sequence comparison of
Etzerodt, Anders, Rasmussen, Mie Rostved, Møller, Holger Jon, Moestrup, Søren Kragh, Schwarz, Jeanette, Galea, Ian, Chalaris, Athena, Svendsen, Pia   +7 more
core   +1 more source

The class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages [PDF]

, 2017
Internalization of ADAMTS13 by macrophages may contribute to its clearance from the circulation. Here we investigated endocytic mechanisms that contribute to the uptake of ADAMTS13 by macrophages.
Peyron, Ivan, Sorvillo, Nicoletta, Verbij, Fabian C., van Alphen, Floris P.J., van Alphen, Floris P. J., Hrdinova, Johana, Kaijen, Paul H P, Meijer, Sander, van den Breg, Timo, Meijer, Alexander B., van den Berg, Timo K, Kaijen, Poul H. P., Graversen, Jonas Heilskov; id_orcid, Fijnheer, Rob, Biomolecular Mass Spectrometry and Proteomics, Graversen, Jonas J H, Moestrup, Soren K, Moestrup, Søren Kragh, Hdrinova, Johanna, Vorrberg, Jan, Voorberg, Jan, Verbij, Fabian C, Afd Biomol.Mass Spect. and Proteomics, Ten Brinke, Anja   +23 more
core   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

Evaluation of soluble CD163 as a marker of inflammation in psoriasis

Clinical and Experimental Dermatology, 2011
Summary A reliable biomarker of disease activity in psoriasis would be helpful for management, especially if this gave early information on treatment efficacy. This study investigated whether serum levels of soluble (s)CD163 correlated with psoriasis activity as assessed by the Psoriasis Area and Severity Index (PASI).
C, Feighery, J, Dunne, E A, Bingham, C F, Feighery   +3 more
openaire   +2 more sources

Supplementary Figure S3 from CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma

, 2018
The phenotype of macrophages in WT and CD163-/- mice. The expression of CD163 and CD204 was detected in peritoneal macrophages by western blot analysis (A).
Yukio Fujiwara (635612), Yoichi Saito (2435818), Hasita Horlad (2103853), Hiroshi Mizuta (381002), Yoshihiro Komohara (414247), Pan Cheng (1702918), Junko Tsuboki (14930333), Hirofumi Bekki (3501791), Naomi Nakagata (134967), Motohiro Takeya (414255), Daisuke Shiraishi (8591748), Yoshinao Oda (629764), Toyohisa Iriki (4243396), Yasuharu Nakashima (3622085)   +13 more
core   +1 more source

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source

MAGI3 Acts as an Intestinal Epithelial Gatekeeper in Inflammation‐Associated Colorectal Cancer by Suppressing the STAT3‐CCL2 Axis and TAM‐Mediated Immunosuppression

Advanced Science, EarlyView.
Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...
Yumeng Yang, Zhigang Bai, Haibo Wang, Yu Guo, Yan Zhang, Meihan Hu, Shuaikang Fan, Ran Song, Tongmei Zhang, Mengqi Deng, Xiaomei Yang, Zhongtao Zhang, Junqi He   +12 more
wiley   +1 more source

Positive rate of CD163 among breast cancer tissues.

, 2012
Immunohistochemical staining was performed for the M2 marker CD163 (brown) in various human breast cancer tissues. Normal mammary ducts were shown as control. Nuclei were counterstained with hematoxylin (blue) (×100).
Canming Chen (149245), Jiong Wu (87147), Zhiming Shao (149246), Wei Jin (87150), Jingxian Ding (149243)   +4 more
core   +1 more source