Results 111 to 120 of about 49,899 (288)

CD163⁺ chondrocytes in normal joint cartilage of 3-week old rats.

, 2013
A: Immunohistochemical staining of CD163 in cartilage from the TMJ and knee. The CD163+ cells located below the superior zone of the TMJ and knee cartilage, show intense membrane and cytoplasmic staining (arrows).
Xu Cao (104337), Jianjun He (104318), Jintao Hu (104326), Mian Zhang (104308), Yuying Wei (104310), Li-Na Niu (104333), Kun Yang (19445), Mei-Qing Wang (104341), Kai Jiao (104304), Han Zhu (104329), Jing Zhang (23775), Yaoping Wu (104312), Zhong Ying Qiu (104315), Yunxin Cao (104322)   +13 more
core   +1 more source

MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li, Jia Deng, Lin Sun, Shihui Wang, Huizhi Li, Jing Chen, Lipan Zhao, Xilin Shen, Yan Sun   +8 more
wiley   +1 more source

HOXA9 and CD163 potentiate pancreatic ductal adenocarcinoma progression

Diagnostic Pathology
Background The role of HOXA9 requires investigations in pancreatic ductal adenocarcinoma (PDAC) as HOXA9 inhibitors are being developed. HOXA9 might attract CD163 expressed tumor associated macrophages (TAM) and could affect PDAC prognosis.
Aiat Shaban Hemida, Mohamed Mohamady Ahmed, Mona Saeed Tantawy   +2 more
doaj   +1 more source

CD163⁺ monocytes and soluble CD163 as prognostic indicators in severe fever with thrombocytopenia syndrome: An integrative analysis

PLOS Neglected Tropical Diseases
Background Severe fever with thrombocytopenia syndrome (SFTS) carries high short-term mortality and lacks approved antiviral therapy, highlighting the need for admission risk tools grounded in upstream host immune pathobiology. Methods
Jie Wang, Haolin Song, Yi Zhang, Ziling Cheng, Lingtong Huang, Bei Jia, Guangqi Zhu, Lifen Hu, Jihua Xue, Jie Li, Wei Wu, Qi Xia   +11 more
openaire   +2 more sources

Quantification of CD163+ BAL cells by flow-cytometry.

, 2015
Fig (3a) shows representative flow-cytometry histograms from studied groups. Fluorescence was compared to unstained controls for 35,000 events in each histogram display, and the stained APC-CD163 positive events were compensated for unstained events by ...
Paul Wilson (146891), Paul E. Wischmeyer (118482), Qianbin He (766270), Luke Domaleski (766269), John E. Repine (766273), Angela F. D. Moss (766272), Amanda Agazio (766267), Kaily A. Baer (766271), Ana Fernandez-Bustamante (766266), Nancy Elkins (766268)   +9 more
core   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

BTK Inhibitor Ibrutinib Reduces Bispecific Antibody-Related CRS Without Undermining the Anti-Tumor Efficacy. [PDF]

Cancer Sci
BTK inhibition reprograms macrophages to suppress IL‐6/IL‐8/IL‐10‐driven CRS without compromising BsAb efficacy. ABSTRACT Bispecific antibodies (BsAbs) have shown marked efficacy in relapsed or refractory (R/R) B‐cell non‐Hodgkin lymphoma (B‐NHL). However, their clinical utility is constrained by cytokine release syndrome (CRS).
Cao J, Hu D, Lv J, Chai J, Wang Y, Chen J, Yan X, Zhu J, Yu H.   +8 more
europepmc   +2 more sources

The Cryo-EM structure of human CD163 bound to haptoglobin-hemoglobin reveals molecular mechanisms of hemoglobin scavenging

Nature Communications
CD163, a macrophage-specific receptor, plays a critical role in scavenging hemoglobin released during hemolysis, protecting against oxidative effects of heme iron.
Anders Etzerodt, Jakob Hauge Mikkelsen, Morten Torvund-Jensen, Dorle Hennig, Thomas Boesen, Jonas Heilskov Graversen, Søren Kragh Moestrup, Justin M. Kollman, Christian Brix Folsted Andersen   +8 more
doaj   +1 more source

Relationship between serum IL-8 and IL-8(T), between serum IL-8 and CD163(IF), between IL-8(T) and CD163(IF).

, 2014
The statistical relationships were detected by two-sided Fisher exact test.
Masato Okamoto (390314), Shigeo Koido (390312), Hiroyuki Goda (668180), Tomoyuki Tano (668181), Sadamu Homma (390313), Yohei Fujita (668179), Tomonobu Fujita (668183), Koh-ichi Nakashiro (551821), Atsuro Sugita (668182), Yutaka Kawakami (206073), Hiroyuki Hamakawa (668184)   +10 more
core   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source