Results 181 to 190 of about 49,899 (288)

Inhibition of the MER tyrosine kinase ameliorates pulmonary fibrosis by suppressing macrophage M2 polarisation and osteopontin signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose The MER proto‐oncogene tyrosine kinase (MERTK) has been implicated in the pathogenesis of pulmonary fibrosis (PF), and MERTK inhibition has been shown to ameliorate PF. However, the mechanisms remain unclear. Here, we have investigated how MERTK inhibition attenuates bleomycin (BLM)‐induced PF in mice and to elucidate the ...
Juan Li, Xiangsheng Yang, Xiao Xiao Tang
wiley   +1 more source

Immunophenotypic Features of CD68 and CD163 Distribution in Oral Squamous Cell Carcinoma of Tongue and Lip. [PDF]

Diseases
Demyashkin G, Kostin A, Epifanova M, Epifanov A, Blinova E, Kasianov A, Shchekin V, Tsomartova D, Vadyukhin M, Shegai P, Kaprin A.   +10 more
europepmc   +1 more source

A Novel Plasma Biomarker hsa_circ_0080018 Drives DLBCL Progression via M2 Polarization of Tumor‐Associated Macrophages

Cancer Science, EarlyView.
The proposed mechanistic model in this study. ABSTRACT Noncoding RNAs, including circular RNAs (circRNAs), have been demonstrated to play vital roles in tumorigenesis. Uncovering the functions of circRNAs in tumorigenesis and their underlying regulatory mechanisms may suggest new approaches to the development of novel diagnostic and therapeutic ...
Yanfeng Liu, Yanan Gao, Chuanli Zhao
wiley   +1 more source

CCR5, CD163, CSF1R, and FCGR3A as Candidate Biomarkers Associated With Mitophagy in Atherosclerosis. [PDF]

Hum Mutat
Fu J, Dong Y.
europepmc   +1 more source

Spatial Atlas of Small Cell Lung Carcinoma Reveals Intratumoral Tumor‐State Heterogeneity and an MMP12+ Macrophage Niche

Cancer Science, EarlyView.
Spatial transcriptomic profiling of SCLC revealed marked intratumoral heterogeneity, including coexisting neuroendocrine and non‐neuroendocrine states and spatially heterogeneous hypoxia, and identified an MMP12+ macrophage population enriched at hypoxic and necrotic tumor interfaces.
Naozane Nomura, Naoe Jimbo, Takaaki Nakanishi, Yukinobu Ito, Maki Sakaguchi, Daichi Maeda, Hiroko Ikeda, Tsukasa Ueda, Hayato Koba, Seiji Yano, Isao Matsumoto, Patrick Micke, Takayuki Kodama, Manabu Shigeoka, Yu‐ichiro Koma, Masafumi Horie   +15 more
wiley   +1 more source

Angiogenic and Stromal Remodeling Associated With Aggressive Fibrosarcomatous Dermatofibrosarcoma Protuberans [PDF]

Cancer Sci
FS‐DFSP exhibits coordinated angiogenic and stromal remodeling characterized by immature vascular features, CAF accumulation, and enhanced macrophage infiltration. VEGFA, CCL2, and CXCR4 may contribute to this tumor‐promoting microenvironment. ABSTRACT Although collagen type 1 alpha 1 (COL1A1)–platelet‐derived growth factor B‐chain (PDGFB) gene fusion ...
Shiraishi S, Iwasaki T, Takigawa K, Kawaguchi K, Sonoda H, Miyawaki K, Tomonaga T, Mori T, Endo M, Kato K, Nakashima Y, Oda Y.   +11 more
europepmc   +2 more sources

Predicting recurrence risk after neoadjuvant therapy in breast cancer: a single-center retrospective cohort study integrating residual cancer burden and immune microenvironment features. [PDF]

Front Oncol
Zhao Z, Deng R, Bai L, Duan X, Yi J.
europepmc   +1 more source

Dynamic Changes in Macrophage Infiltration and Polarization During Oral Carcinogenesis and Tumor Progression. [PDF]

Biomedicines
Arashima T, Takabatake K, Zhao Y, Liu Z, Li Z, Kawai H, Eain HS, Min ZZ, Nakano K, Nagatsuka H.   +9 more
europepmc   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Mapping the immune microenvironment of <i>KIT</i>- and <i>PDGFRA</i>-mutant GISTs reveals genotype-specific immune infiltration and TKI-induced remodeling. [PDF]

Front Immunol
Costa A, Nigro MC, Grillini M, Gozzellino L, Nannini M, Motta I, De Leo A, Pirini MG, Del Gaudio M, Ravaioli M, Ianni M, Pasquinelli G, Astolfi A, Pantaleo MA.   +13 more
europepmc   +1 more source