Results 81 to 90 of about 48,020 (257)

Macrophage Cluster of Differentiation 163 promotes post‐infarction cardiac repair and preserves left ventricular function via osteopontin

Clinical and Translational Medicine
Background Cardiac macrophages (cMacs) have been implicated in myocardial repair following myocardial infarction (MI), yet their therapeutic potential in ischaemic cardiomyopathy (ICM) remains limited by an incomplete understanding of their molecular ...
Jingyu Chen, Linjian Chen, Wei Huang, Gang Wang, Lin Wang, Wanchun Mei, Wei Ni, Yang Liu, Licheng Ding, Xiaofeng Ge, Zhaokai Li, Jing Yu, Shufen Huang, Jiayi Lin, Yifan Chen, Binni Cai, Peng Zhang, Cuilian Dai, Binbin Liu   +18 more
doaj   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Pigs with CD163 Mutation Conferred PRRSV Resistance

Porcine reproductive and respiratory syndrome (PRRS), which is caused by the porcine reproductive and respiratory syndrome virus (PRRSV), results in substantial economic losses for the global pig farming industry. A critical step in the infection process
Heyao Wang, Wei Zhang, Yanfeng Dai, Lian Chen, Changbao Wu, Chao Tang, Miaomiao Cheng, Yang Wang, Liping Zhang   +8 more
core   +1 more source

Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady-state condition but not in response to calorie restriction.

, 2014
International audienceCONTEXT: Soluble CD163 (sCD163) was suggested as a biomarker of insulin sensitivity and CD163 mRNA expression representing macrophage content in adipose tissue (AT).
Mališová, Lucia, Langin, Dominique, Klimčáková, Eva, Tencerová, Michaela, Šiklová, Michaela, Kračmerová, Jana, Polák, Jan, Štich, Vladimír, Kováčová, Zuzana, Rossmeislová, Lenka   +9 more
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

CD163 deficiency facilitates lipopolysaccharide‐induced inflammatory responses and endotoxin shock in mice

Clinical & Translational Immunology, 2020
Objectives Septic (or endotoxin) shock is a severe systemic inflammatory disease caused by bacteraemia or endotoxaemia. Although it is known that increased serum levels of CD163 are observed in septic/endotoxin shock patients, the exact function and ...
Yukio Fujiwara, Koji Ohnishi, Hasita Horlad, Yoichi Saito, Daisuke Shiraishi, Hiroto Takeya, Daiki Yoshii, Shinjiro Kaieda, Tomoaki Hoshino, Yoshihiro Komohara   +9 more
doaj   +1 more source

Quantification of CD163+ BAL cells by flow-cytometry.

, 2015
Fig (3a) shows representative flow-cytometry histograms from studied groups. Fluorescence was compared to unstained controls for 35,000 events in each histogram display, and the stained APC-CD163 positive events were compensated for unstained events by ...
Paul Wilson (146891), Paul E. Wischmeyer (118482), Qianbin He (766270), Luke Domaleski (766269), John E. Repine (766273), Angela F. D. Moss (766272), Amanda Agazio (766267), Kaily A. Baer (766271), Ana Fernandez-Bustamante (766266), Nancy Elkins (766268)   +9 more
core   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

HOXA9 and CD163 potentiate pancreatic ductal adenocarcinoma progression

Diagnostic Pathology
Background The role of HOXA9 requires investigations in pancreatic ductal adenocarcinoma (PDAC) as HOXA9 inhibitors are being developed. HOXA9 might attract CD163 expressed tumor associated macrophages (TAM) and could affect PDAC prognosis.
Aiat Shaban Hemida, Mohamed Mohamady Ahmed, Mona Saeed Tantawy   +2 more
doaj   +1 more source

Lesional accumulation of CD163-expressing cells in the gut of patients with inflammatory bowel disease.

PLoS ONE, 2013
Monocytes/macrophages displaying different markers of activation/differentiation infiltrate the inflamed gut of patients with inflammatory bowel diseases (IBD), but the role that each monocyte/macrophage subpopulation plays in the pathogenesis of IBD is ...
Eleonora Franzè, Roberta Caruso, Carmine Stolfi, Massimiliano Sarra, Maria Laura Cupi, Flavio Caprioli, Ivan Monteleone, Francesca Zorzi, Daniela De Nitto, Alfredo Colantoni, Livia Biancone, Francesco Pallone, Giovanni Monteleone   +12 more
doaj   +1 more source