Results 81 to 90 of about 49,899 (288)

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Scavenger Receptor CD163 and Its Biological Functions [PDF]

Acta Medica (Hradec Kralove, Czech Republic), 2009
CD163 is a member of scavenger receptor super family class B of the first subgroup. It is mapped to the region p13 on chromosome 12. Five different isoforms of CD163 have been described, which differ in the structure of their cytoplasmic domains and putative phosporylation sites.
Gabriela Onofre, Martina Koláčková, Karolína Jankovičová, Jan Krejsek   +3 more
openaire   +3 more sources

CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages

, 2011
CXCL4 is a platelet-derived chemokine that promotes macrophage differentiation from monocytes. Deletion of the PF4 gene that encodes CXCL4 reduces atherosclerotic lesions in Apoe -/- mice.
Erbel, C, Böckler, D, Ley, E, Katus, HA, Gleissner, CA, Shaked, I   +5 more
core   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice [PDF]

, 2020
Atherosclerosis is an inflammatory disease characterized by the accumulation of macrophages in the vessel wall. Macrophages depend on their polarization to exert either pro-inflammatory or anti-inflammatory effects.
Méndez-Barbero, Nerea, Escolà-Gil, Joan Carles, Sastre, Cristina, Moestrup, Soren K., Martín-Ventura, Jose Luis, Blanco-Colio, Luis M., Martín-Ventura, Jose L., Blanco-Colio, Luis Miguel, Gutiérrez-Muñoz, Carmen, Egido, Jesús, Escolá-Gil, Joan C., Fernández-Laso, Valvanera, Quesada, Patricia, Svendsen, Pia, Gutiérrez Muñoz, Carmen, Nerea Méndez‐Barbero, Carmen Gutiérrez‐Muñoz, Cristina Sastre, Valvanera Fernández‐Laso, Patricia Quesada, Jose L. Martín‐Ventura, Luis M. Blanco‐Colio, Joan C. Escolá‐Gil, Pia Svendsen, Soren K. Moestrup, Jesús Egido   +25 more
core   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Relationships of CD163 and CD169 positive cell numbers in the endometrium and fetal placenta with type 2 PRRSV RNA concentration in fetal thymus [PDF]

, 2016
Several routes of porcine reproductive and respiratory virus PRRSV transmission across the porcine diffuse epitheliochorial placentation have been proposed, but none have been proven.
Detmer, Susan E., Harding, John C. S., Novakovic, Predrag, Ladning, Andrea, Al-Dissi, Ahmad N., MacPhee, Daniel J.   +5 more
core   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Double immunostaining (NRPs vs CD68, CD163, HO-1 and DC-SIGN) and triple immunohistochemistry (CD68, CD163 and NRP-1) of lung tissue adjacent to the cancer.

, 2016
(A) Double IF showed expression of CD68, CD163 and HO-1 (Rhodamine, anti-mouse, red color) on NRP-1+(Fluorescein, anti-rabbit, green color) alveolar macrophages. White arrows showed double positive cells.
Hongxue Meng (2272915), Tomoya Kato (2124757), Mitsunori Yamakawa (641922), Suran Yang (2272906), Naing Ye Aung (2272909), Takanobu Kabasawa (2272912), Rintaro Ohe (641921)   +6 more
core   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source