Results 151 to 160 of about 175,178 (288)

Blinatumomab bridges the gap between leukemia and immunity

OncoImmunology, 2017
Takahiro Yamazaki, Lorenzo Galluzzi
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

CD19 Gene [PDF]

, 2020
openaire   +1 more source

Ocrelizumab‐induced colitis: VigiBase disproportionality analysis, case reports and literature review

British Journal of Clinical Pharmacology, EarlyView.
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse, Christophe Hommel, Nadine Petitpain, Philippe Kerschen   +3 more
wiley   +1 more source

DP028 | CD19.CAR-T CELL-DERIVED EXTRACELLULAR VESICLES RETAIN CAR EXPRESSION AND EXHIBIT CYTOTOXIC ACTIVITY AGAINST LEUKEMIC CELLS, SUPPORTING THEIR ROLE IN ANTITUMOR THERAPY.

Haematologica
CAR-T cell therapy has revolutionized the treatment of hematologic malignancies. Nevertheless, significant challenges remain, particularly concerning its severe adverse effects. Extracellular vesicles (EVs) emerged as promising therapeutic agents due to
P. Lanuti, F. Guardalupi, G. Corradi, R. Florio, D. Brocco, S. Veschi, E. Pennese, D. De Bellis, F. D’ascanio, A. Piro, L. De Lellis, P. Simeone, M. C. Cufaro, S. Pilato, I. D’amario, I. Villanova, B. Di Francesco, L. Di Re, F. Verginelli, D. Pieragostino, P. Salutari, F. Colasante, A. Natale, M. V. Mattioli, A. Fontana, R. Giancola, B. Fabi, S. Baldoni, S. Santarone, F. Restuccia, N. Tinari, P. Del Boccio, A. Cama, M. Di Ianni   +33 more
doaj  

The Squalene Oil‐in‐Water Nanoemulsion Vaccine Carrier AddaVax Potentiates TLR‐Induced B‐Cell Responses

Cytometry Part A, EarlyView.
ABSTRACT For vaccination, the mechanisms of action of antigens and of immunostimulatory pathogen‐associated molecular pattern (PAMP) adjuvants are better understood than the roles of the depot, carrier, and other formulation‐related influences. Here, we carried out cytometric studies of vaccine formulations and the effect of adjuvant formulations on B ...
Egest J. Pone, Jiin Felgner, Jenny Hernandez‐Davies, D. Huw Davies   +3 more
wiley   +1 more source

Prospective validation of podoplanin expression as a diagnostic biomarker of acute promyelocytic leukemia

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Acute promyelocytic leukemia (APL) is a medical emergency that needs immediate diagnosis and treatment. Podoplanin, a transmembrane glycoprotein that binds CLEC‐2 on platelets, was recently demonstrated to be abnormally expressed in leukemic blasts in APL, as opposed to other forms of AML, in a study using thawed primary cells.
Camilla Maria de Alencar Saraiva, Carla Roberta Peachazepi Moraes, Bruno Kosa Lino Duarte, Gislaine Borba Oliveira, Herton Luiz Alves Sales Filho, Paula de Melo Campos, Sara Teresinha Olalla Saad, Erich Vinicius De Paula   +7 more
wiley   +1 more source

CD19 Positive [PDF]

, 2020
openaire   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

CD79A/CD40 intracellular domain uses a 4-1BB-like metabolic pathway driven by cholesterol biosynthesis. [PDF]

J Immunother Cancer
Takeuchi Y, Terakura S, Ishigiwa K, Julamanee J, Hirano S, Yokota H, Kuwano S, Hanajiri R, Kiyoi H.   +8 more
europepmc   +1 more source