Results 1 to 10 of about 7,097 (193)

Expression of CD226 is associated to but not required for NK cell education [PDF]

Nature Communications, 2017
CD226 is an activating receptor expressed in a co-varied manner with inhibitory receptors on natural killer (NK) cells, but whether CD226 is involved in NK cell education is unclear. Here the authors show that CD226 expression is plastic depending on the
Arnika K. Wagner, Nadir Kadri, Johanna Snäll, Petter Brodin, Susan Gilfillan, Marco Colonna, Günter Bernhardt, Petter Höglund, Klas Kärre, Benedict J. Chambers   +9 more
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CD226+ B cells in primary Sjögren’s syndrome: a key player in clinical manifestations and disease pathogenesis [PDF]

Frontiers in Immunology
IntroductionPrimary Sjögren’s syndrome (pSS) is a systemic autoimmune disorder characterized by lymphocytic infiltration of exocrine glands, leading to sicca symptoms and systemic complications.
Ping Zhao, Ping Zhao, Saizhe Song, Song Zhang, Cheng Peng, Wei Cheng, Xin Chang, Xin Chang, Changhao Xie, Zhongli Hu, Cuiping Liu   +10 more
doaj   +2 more sources

CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages [PDF]

Cell Reports
Summary: CD8+ T cells defend against Mycobacterium tuberculosis (Mtb) infection but variably recognize Mtb-infected macrophages. To investigate how chronic infection affects the diversity of lung parenchymal CD8+ T cells, we perform single-cell RNA ...
Tomoyo Shinkawa, Evelyn Chang, Tasfia Rakib, Kelly Cavallo, Rocky Lai, Samuel M. Behar   +5 more
doaj   +2 more sources

iPSC-derived NK cells engineered with CD226 effectively control acute myeloid leukemia [PDF]

Experimental Hematology & Oncology
CD226 plays a vital role in NK cell cytotoxicity, interacting with its ligands on tumor targets. Acute myeloid leukemia (AML) cells have developed mechanisms to escape NK cell cytotoxicity, including inducing downregulation of CD226 on NK cells.
Runze Cai, Binyan Lu, Xiangyu Zhao, Shixin Zhou, Yang Li   +4 more
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Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia [PDF]

Molecular Oncology
CD8+ T cells, a subset of T cells identified by the surface glycoprotein CD8, particularly those expressing the co‐stimulatory molecule CD226, play a crucial role in the immune response to malignancies. However, their role in chronic lymphocytic leukemia
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
doaj   +2 more sources

The Immune Regulatory Functions of CD226 and Its Implications in Immune-Mediated Diseases [PDF]

Biomolecules
CD226, a member of the immunoglobulin superfamily, serves as a critical regulator in various immunological processes. CD226 is expressed across immune and non-immune cells, with predominant expression being observed in natural killer (NK) cells and T ...
Keyan Liu, Yuanzhen Liu, Huabao Xiong, Zhaochen Ning   +3 more
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CD155-TIGIT/CD96/CD226 immune checkpoint axis interacting with tumor-infiltrating lymphocytes to exhibit diverse prognostic effects on breast cancer: a cohort study [PDF]

Frontiers in Immunology
BackgroundCD155, an immune checkpoint molecule interacted with receptors of TIGIT/CD96/CD226 to exhibit co-inhibitory and co-stimulatory modulation on tumor immune microenvironment. Nevertheless, the exploration of collectively prognostic effect of these
Xin Ou, Xin Ou, Junyu Yin, Junyu Yin, Feng Shi, Yanjie Zhao, Quan Zhou, Keyu Yuan, Shuzhen Lyu, Jiangping Wu, Jiangping Wu, Yanping Li, Qingkun Song, Qingkun Song   +13 more
doaj   +2 more sources

Immunotherapeutic strategies targeting the PVR–TIGIT/CD96/CD226 signaling pathway in glioma treatment [PDF]

Annals of Medicine
Background To summarise the molecular interactions of Poliovirus Receptor (PVR) with its receptors (inhibitory TIGIT/CD96 and activating CD226), to delineate how these interactions drive glioma immune escape, and to evaluate emerging PVR-directed ...
Da Qian, Jiazheng Guo, Yuchen Duan, Yibing Zhou, Chaoshen Wu, Qun Chen, Jinquan Cai   +6 more
doaj   +2 more sources

Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells [PDF]

Cell Reports
Summary: CD226 plays a vital role in natural killer (NK) cell cytotoxicity, interacting with its ligands CD112 and CD155 to initiate immune synapse formation, primarily through leukocyte function-associated-1 (LFA-1). Our study examined the role of CD226
Luciana Melo Garcia, Achintyan Gangadharan, Pinaki Banerjee, Ye Li, Andy G.X. Zeng, Hind Rafei, Paul Lin, Bijender Kumar, Sunil Acharya, May Daher, Luis Muniz-Feliciano, Gary M. Deyter, Gabriel Dominguez, Jeong Min Park, Francia Reyes Silva, Ana Karen Nunez Cortes, Rafet Basar, Nadima Uprety, Mayra Shanley, Mecit Kaplan, Enli Liu, Elizabeth J. Shpall, Katayoun Rezvani   +22 more
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CD226 implicated in Akt-dependent apoptosis of CD4+ T cell contributes to asthmatic pathogenesis [PDF]

Cell Death and Disease
Asthma is a chronic airway inflammatory disease in which CD4+ T cell dysregulation occurs. Here, we investigated the molecular role and clinical significance of CD226, a costimulatory molecule of T lymphocytes, in the development of allergic asthma.
Yuan Zhang, Yang Xie, Xuexin Zhang, Chujun Duan, Jingchang Ma, Yuling Wang, Yilin Wu, Niqi Shan, Kun Cheng, Ran Zhuang, Ka Bian   +10 more
doaj   +2 more sources