Results 11 to 20 of about 7,097 (193)

CD226: An Emerging Role in Immunologic Diseases [PDF]

Frontiers in Cell and Developmental Biology, 2020
CD226, a member of the immunoglobulin superfamily, is a functional protein initially expressed on natural killer and T cells. In recent years, the function of CD226 has been increasingly realized and researched.
Zhiyi Huang, Guangyin Qi, Joseph S. Miller, Song Guo Zheng   +3 more
doaj   +3 more sources

Emergence of the CD226 Axis in Cancer Immunotherapy

Frontiers in Immunology, 2022
In recent years, a set of immune receptors that interact with members of the nectin/nectin-like (necl) family has garnered significant attention as possible points of manipulation in cancer.
Michael Conner, Ken W. Hance, Sapna Yadavilli, James Smothers, Jeremy D. Waight   +4 more
doaj   +3 more sources

Increased levels of soluble CD226 in sera accompanied by decreased membrane CD226 expression on peripheral blood mononuclear cells from cancer patients [PDF]

BMC Immunology, 2009
Background As a cellular membrane triggering receptor, CD226 is involved in the NK cell- or CTL-mediated lysis of tumor cells of different origin, including freshly isolated tumor cells and tumor cell lines.
Xu Zhuwei, Zhang Tao, Zhuang Ran, Zhang Yun, Jia Wei, Song Chaojun, Yang Kun, Yang Angang, Jin Boquan   +8 more
doaj   +3 more sources

TGF-β-mediated crosstalk between TIGIT+ Tregs and CD226+CD8+ T cells in the progression and remission of type 1 diabetes [PDF]

Nature Communications
Type 1 diabetes (T1D) is a chronic autoimmune condition characterized by hyperglycemia resulting from the destruction of insulin-producing β-cells that is traditionally deemed irreversible, but partial remission (PR) with temporary reversal of ...
Ting Zhong, Xinyu Li, Kang Lei, Rong Tang, Qiaolin Deng, Paul E Love, Zhiguang Zhou, Bin Zhao, Xia Li   +8 more
doaj   +2 more sources

TIGIT/CD226 Axis Regulates Anti-Tumor Immunity [PDF]

Pharmaceuticals, 2021
Tumors escape immune surveillance by inducing various immunosuppressive pathways, including the activation of inhibitory receptors on tumor-infiltrating T cells. While monoclonal antibodies (mAbs) blocking programmed cell death 1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) have been approved for ...
Jinah Yeo, Minkyung Ko, Dong-Hee Lee, Yoon Park, Hyung-seung Jin   +4 more
openaire   +3 more sources

Identifying Therapeutic Targets for Bronchial Asthma: Systematic Druggable Genome-Wide Mendelian Randomization. [PDF]

Health Sci Rep
ABSTRACT Background The treatment and prevention of bronchial asthma continue to present significant challenges. Mendelian randomization (MR) has been extensively employed to identify novel therapeutic targets. Consequently, we conducted a systematic MR analysis across the druggable genome to identify potential therapeutic targets for asthma.
Wang H, Zhang P, Yu H, Shi L, Wang T.
europepmc   +2 more sources

Increased Proportion of CD226+ B Cells Is Associated With the Disease Activity and Prognosis of Systemic Lupus Erythematosus

Frontiers in Immunology, 2021
BackgroundCD226, an activating receptor expressed on the surface of natural killer (NK) cells and T cells, is also seen on B cells and CD226 polymorphism is associated with systemic lupus erythematosus (SLE).
Miki Nakano, Masahiro Ayano, Masahiro Ayano, Kazuo Kushimoto, Shotaro Kawano, Kazuhiko Higashioka, Shoichiro Inokuchi, Hiroki Mitoma, Yasutaka Kimoto, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro   +14 more
doaj   +1 more source

Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis

Arthritis Research & Therapy, 2021
Background T cell Ig and ITIM domain (TIGIT)/CD226 pathway has a critical role in regulating T cell responses and has come to the forefront in cancer as a promising immunotherapeutic target.
Wenli Li, Chuiwen Deng, Hanbo Yang, Xin Lu, Shanshan Li, Xia Liu, Fang Chen, Lida Chen, Xiaoming Shu, Lu Zhang, Qingyan Liu, Guochun Wang, Qinglin Peng   +12 more
doaj   +1 more source

CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

Cell Reports, 2023
Summary: Regulatory T (Treg) cells exhibit immunosuppressive phenotypes and particular metabolic patterns with certain degrees of plasticity. Previous studies of the effects of the co-stimulatory molecule CD226 on Treg cells are controversial.
Jingchang Ma, Wei Hu, Yitian Liu, Chujun Duan, Dongliang Zhang, Yuling Wang, Kun Cheng, Lu Yang, Shuwen Wu, Boquan Jin, Yuan Zhang, Ran Zhuang   +11 more
doaj   +1 more source

CD226 Is Required to Maintain Megakaryocytes/Platelets Homeostasis in the Treatment of Knee Osteoarthritis With Platelet-Rich Plasma in Mice

Frontiers in Pharmacology, 2021
Platelet-rich plasma (PRP) is a platelet-based application used to treat osteoarthritis (OA) clinically. The co-stimulatory molecule CD226 is expressed in T cells, NK cells, and also platelets. However, exact effects of CD226 on platelets and whether its
Yongming Liu, Yuan Zhang, Jinxue Zhang, Jingchang Ma, Ka Bian, Yuling Wang, Xuexue Xu, Shuwen Wu, Kun Cheng, Yun Zhang, Yong Ding, Yong Zhou, Ran Zhuang, Ran Zhuang   +13 more
doaj   +1 more source