Results 21 to 30 of about 7,097 (193)

CD226 Gly307Ser association with multiple autoimmune diseases [PDF]

Genes & Immunity, 2008
Genome-wide association studies provide insight into multigenic diseases through the identification of susceptibility genes and etiological pathways. In addition, the identification of shared variants among autoimmune disorders provides insight into common disease pathways.
Hafler, J. P., Maier, L. M., Cooper, J. D., Plagnol, V., Hinks, A., Simmonds, M. J., Stevens, H. E., Walker, N. M., Healy, B., Howson, J. M M, Maisuria, M., Duley, S., Coleman, G., Gough, S. C L, Worthington, J., Kuchroo, V. K., Wicker, L. S., Todd, J. A.   +17 more
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Imbalance of the CD226/TIGIT Immune Checkpoint Is Involved in the Pathogenesis of Primary Biliary Cholangitis

Frontiers in Immunology, 2020
The relationship between the cluster of differentiation 226 (CD226)/T cell Ig and ITIM domain (TIGIT) immune checkpoint and primary biliary cholangitis (PBC) pathogenesis is unknown.
Chuiwen Deng, Wenli Li, Yunyun Fei, Li Wang, Yingying Chen, Xiaofeng Zeng, Fengchun Zhang, Yongzhe Li   +7 more
doaj   +1 more source

CD226 and TIGIT Cooperate in the Differentiation and Maturation of Human Tfh Cells

Frontiers in Immunology, 2022
Costimulation pathways play an essential role in T cell activation, differentiation, and regulation. CD155 expressed on antigen-presenting cells (APCs) interacts with TIGIT, an inhibitory costimulatory molecule, and CD226, an activating costimulatory ...
Motoko Yasutomi, Allison F. Christiaansen, Naoko Imai, Natalia Martin-Orozco, Christian V. Forst, Gang Chen, Hideki Ueno, Hideki Ueno, Hideki Ueno   +8 more
doaj   +1 more source

Expression of DNAM-1 (CD226) on inflammatory monocytes [PDF]

Molecular Immunology, 2016
DNAM-1 is an activating receptor expressed on NK cells and T cells and plays an important role in cytotoxicity of these cells against target cells. Although the role of DNAM-1 in the function of T cells and NK cells has been well studied, the expression and function of DNAM-1 on myeloid cells have been incompletely understood.
Anh Van, Vo, Eri, Takenaka, Akira, Shibuya, Kazuko, Shibuya   +3 more
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CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation

Frontiers in Immunology, 2020
The costimulatory molecule CD226 is highly expressed on effector/memory T cells and natural killer cells. Costimulatory signals received by T cells can impact both central and peripheral tolerance mechanisms.
Melanie R. Shapiro, Wen-I Yeh, Joshua R. Longfield, John Gallagher, Caridad M. Infante, Sarah Wellford, Amanda L. Posgai, Mark A. Atkinson, Mark A. Atkinson, Martha Campbell-Thompson, Scott M. Lieberman, David V. Serreze, Aron M. Geurts, Yi-Guang Chen, Todd M. Brusko, Todd M. Brusko   +15 more
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CD226 opposes TIGIT to disrupt Tregs in melanoma [PDF]

JCI Insight, 2018
CD4+ Tregs impede T cell responses to tumors. They express multiple inhibitory receptors that support their suppressive functions, including T cell Ig and ITIM domain (TIGIT). In melanoma patients, we show that Tregs exhibit increased TIGIT expression and decreased expression of its competing costimulatory receptor CD226 as compared with CD4+ effector ...
Julien Fourcade, Zhaojun Sun, Joe-Marc Chauvin, Mignane Ka, Diwakar Davar, Ornella Pagliano, Hong Wang, Sofiane Saada, Carmine Menna, Rada Amin, Cindy Sander, John M. Kirkwood, Alan J. Korman, Hassane M. Zarour   +13 more
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CD226 identifies functional CD8+T cells in the tumor microenvironment and predicts a better outcome for human gastric cancer

Frontiers in Immunology, 2023
It is well-known that CD226 serves as a critical activating receptor on various immune cells, such as lymphocytes and monocytes, and it is suggested to promote anti-tumor immunity in the tumor microenvironment (TME).
Hao Huang, Hao Huang, Hao Huang, Ziyi Huang, Ziyi Huang, Ziyi Huang, Junwei Ge, Junwei Ge, Junwei Ge, Jiayi Yang, Jiayi Yang, Jiayi Yang, Junjun Chen, Junjun Chen, Junjun Chen, Bin Xu, Bin Xu, Bin Xu, Shaoxian Wu, Shaoxian Wu, Shaoxian Wu, Xiao Zheng, Xiao Zheng, Xiao Zheng, Lujun Chen, Lujun Chen, Lujun Chen, Xueguang Zhang, Xueguang Zhang, Xueguang Zhang, Jingting Jiang, Jingting Jiang, Jingting Jiang   +32 more
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CD226 Throttles up CD8+ T Cell Antitumor Activity [PDF]

Immunity, 2020
In this issue of Immunity, Weulersse et al. and Braun et al. explain how CD226 expression loss on CD8+ T cells impairs TCR-driven activation, and thereby anti-tumor effector responses, tantamount to taking the CD8+ T cell's foot off the gas pedal.
openaire   +2 more sources

Identification and Characterization of the CD226 Gene Promoter [PDF]

Journal of Biological Chemistry, 2006
CD226 is one of the main activating receptors on natural killer cells, and it can induce cytotoxicity to target cells through interaction with its ligands CD155 or CD112. CD226 is also involved in T cell differentiation, activation, and cytotoxicity. The expression of CD226 on natural killer cells and T cells can be regulated by cytokines and chemical ...
Jin-Long, Jian, Can-Sheng, Zhu, Zhu-Wei, Xu, Wei-Ming, Ouyang, Dong-Chu, Ma, Yuan, Zhang, Li-Jie, Chen, An-Gang, Yang, Bo-Quan, Jin   +8 more
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Increased blood CD226- inflammatory monocytes with low antigen presenting potential correlate positively with severity of hemorrhagic fever with renal syndrome

Annals of Medicine, 2023
Background Hantaan virus (HTNV) infection can cause severe hemorrhagic fever with renal syndrome (HFRS). Inflammatory monocytes (iMOs) are involved in early antiviral responses.
Kang Tang, Yongli Hou, Linfeng Cheng, Yusi Zhang, Juan Li, Qi Qin, Xuyang Zheng, Xiaozhou Jia, Chunmei Zhang, Ran Zhuang, Yun Zhang, Boquan Jin, Lihua Chen, Ying Ma   +13 more
doaj   +1 more source