Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells [PDF]
, 2017 Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation ...
Cippitelli, M +13 more
core +1 more source
Genetic variant rs763361 regulates multiple sclerosis CD226 gene expression [PDF]
Proceedings of the National Academy of Sciences, 2017 In a recent study, Gross et al. investigate the presence, distribution, and function of natural killer (NK) cells in three different compartments to characterize the role of NK cells in multiple sclerosis (MS) (1). Their results indicate that NK cells played an important role in controlling T-cell activity in vivo. In addition, Gross et al.
Guiyou, Liu +3 more
openaire +2 more sources
CD155 on HIV-infected cells is not modulated by HIV-1 Vpu and Nef but synergizes with NKG2D ligands to trigger NK cell lysis of autologous primary HIV-infected cells [PDF]
, 2017 Activation of primary CD4(+) T cells induces the CD155, but not the CD112 ligands for the natural killer (NK) cell activation receptor (aNKR) CD226 [DNAX accessory molecule-1 (DNAM-1)].
Barker, Edward +5 more
core +2 more sources
Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. [PDF]
, 2009 BACKGROUND: The genetic contribution to the aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is not well defined.
Carr, Edward J +6 more
core +3 more sources
Frontiers in Immunology, 2022 Regulatory T cell (Treg) adoptive cell therapy (ACT) represents an emerging strategy for restoring immune tolerance in autoimmune diseases. Tregs are commonly purified using a CD4+CD25+CD127lo/- gating strategy, which yields a mixed population: 1) cells ...
Matthew E. Brown +14 more
doaj +1 more source
IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation [PDF]
, 2016 The inflammatory activation and recruitment of defined myeloid populations is essential for controlling the bridge between innate and adaptive immunity and shaping the immune response to microbial challenge.
Davies, Luke C. +10 more
core +1 more source
Journal of Translational Medicine, 2021 Obesity is associated with chronic low-grade inflammation, contributing to an increasing prevalence of chronic metabolic diseases, such as insulin resistance, non-alcoholic fatty liver disease (NALFD), and steatohepatitis. Macrophages are the predominant
Jingchang Ma +11 more
doaj +1 more source
Parasite, 2021 The surface protein TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain) has been characterized as an important regulator of cell-mediated immune responses in various infections.
Wang Shuai +6 more
doaj +1 more source
Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT) [PDF]
, 2017 T cell immunoglobulin and ITIM domain (TIGIT) is an inhibitory receptor expressed on the surface of natural killer (NK) cells. TIGIT recognizes nectin and nectin-like adhesion molecules and thus plays a critical role in the innate immune response to ...
Berry, Richard +3 more
core +2 more sources
Expression of CD226 Antagonizes Apoptotic Cell Death in Murine Thymocytes [PDF]
The Journal of Immunology, 2009 Abstract CD226 is known to be expressed on many types of peripheral lymphoid cells and involved in T cell differentiation, activation, and cytotoxicity. In this study, we report that CD226 is also expressed on mouse thymocytes at varying developmental stages, and its expression is associated with resistance of thymocytes to apoptosis ...
Liang, Fang +10 more
openaire +2 more sources