Results 91 to 100 of about 83,609 (361)

CD36 and lipid metabolism in the evolution of atherosclerosis [PDF]

British Medical Bulletin, 2018
CD36 is a multi-functional class B scavenger receptor, which acts as an important modulator of lipid homeostasis and immune responses.This review uses academic articles.CD36 is closely related to the development and progression of atherosclerosis.Both persistent up-regulation of CD36 and deficiency of CD36 increase the risk for atherosclerosis ...
Xiong Z. Ruan, Xiong Z. Ruan, Xiong Z. Ruan, Zac Varghese, Yaxi Chen, Lei Zhao, John F. Moorhead   +6 more
openaire   +4 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Effects of different long-chain fatty acids on lipid uptake and CD36 palmitoylation in small intestinal epithelial cells of mouse

Huanan Nongye Daxue xuebao
ObjectiveTo investigate the impacts of various long-chain fatty acids on fatty acid uptake and the palmitoylation of cluster of differentiation 36 (CD36) in mouse small intestinal epithelial cells.MethodIn vitro, ModeK, the mouse intestinal epithelial ...
Lilin CAI, Junfeng WANG, Xiaolei YU, Yue ZHANG, Gang SHU, Lina WANG, Qingyan JIANG, Songbo WANG   +7 more
doaj   +1 more source

Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment

Cellular & Molecular Biology Letters, 2023
Background CD36 has been identified as a potential therapeutic target both in leukemic cells and in the tumor immune microenvironment. In acute myeloid leukemia (AML), we found that APOC2 acts with CD36 to promote leukemia growth by activating the LYN ...
Yiting Meng, Mateusz Pospiech, Atham Ali, Ritu Chandwani, Mary Vergel, Sandra Onyemaechi, George Yaghmour, Rong Lu, Houda Alachkar   +8 more
doaj   +1 more source

CD36 in atherosclerosis

Nepalese Heart Journal, 2013
CD36 was described nearly 30 years ago as “glycoprotein IV” the fourth major band of 88KD observed on SDS-PAGE of platelet membrane (1). It is present on many mammalian cell types: microvascular endothelium; professional phagocytes including macrophages, dendritic cells, microglia and retinal pigment-epithellium; erythroid precursors; hepatocytes ...
openaire   +3 more sources

Plaque‐Targeted Delivery of Fluoride‐Free MXene Nanozyme for Alleviating Atherosclerosis via Sonocatalytic Therapy

Advanced Materials, EarlyView.
This work has developed a dual enzyme‐mimicking and ultrasound‐responsive Nb2C‐Pt@HA‐PEG nanozyme. ROS‐eliminating and anti­inflammatory capability of Nb2C‐Pt@HA‐PEG under US irradiation are demonstrated on macrophages and endothelial cells in vitro. Nb2C‐Pt@HA‐PEG‐mediated sonocatalytic therapy exerts an outstanding anti‐atherosclerosis efficacy by ...
Qianqian Bai, Xinyue Lao, Sin‐Yi Pang, Yifei Zhao, Yuan Liu, Xiao Yu Tian, Jianhua Hao   +6 more
wiley   +1 more source

CD36 Signal Transduction in Metabolic Diseases: Novel Insights and Therapeutic Targeting

Cells, 2021
The cluster of differentiation 36 (CD36) is a scavenger receptor present on various types of cells and has multiple biological functions that may be important in inflammation and in the pathogenesis of metabolic diseases, including diabetes.
U. Karunakaran, Suma Elumalai, J. Moon, K. Won   +3 more
semanticscholar   +1 more source

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation

Journal of Neuroinflammation, 2020
Background The presence of foamy macrophages and microglia containing intracellular myelin remnants is a pathological hallmark of neurodegenerative disorders such as multiple sclerosis (MS).
Elien Grajchen, Elien Wouters, Britt van de Haterd, Mansour Haidar, K. Hardonnière, Tess Dierckx, Jana Van Broeckhoven, Céline Erens, S. Hendrix, S. Kerdine-Römer, J. Hendriks, Jeroen F. J. Bogie   +11 more
semanticscholar   +1 more source

Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy

Advanced Science, EarlyView.
To maximize the efficacy of cancer vaccines, adjuvants, collection, lysis, purification, oxidation, loading sites, and sizes, etc., are investigated. The optimized cancer nanovaccines loading whole tumor antigens can cure all or most tumor‐bearing mice in multiple mouse cancer models.
Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu   +13 more
wiley   +1 more source