Results 91 to 100 of about 77,752 (295)

Variants of CD36 gene and their association with CD36 protein expression in platelets.

Blood transfusion = Trasfusione del sangue, 2014
The relationship between CD36 expression level in platelets and polymorphism of the CD36 gene still needs to be explored. Here, we investigated polymorphisms of the CD36 gene and CD36 expression level in platelets in the Chinese Han population.A total of 477 samples were sequenced for exons 2 to 14 of the CD36 gene using a polymerase chain reaction ...
Xianguo, Xu, Ying, Liu, Xiaozhen, Hong, Shu, Chen, Kairong, Ma, Xiaofei, Lan, Yanling, Ying, Ji, He, Faming, Zhu, Hangjun, Lv   +9 more
openaire   +2 more sources

Cholesterol Metabolism Regulated Nanoliposome Ameliorates Chemo/Photothermal Therapy Reversing CD8+ T Cell Exhaustion

Exploration, EarlyView.
Our work addresses the challenge of treating triple‐negative breast cancer by developing a multifunctional nanoliposome, ictLipo. The goal was to enhance antitumor immunity by combining photothermal therapy and chemotherapy while simultaneously tackling two major roadblocks: immunosuppression from cholesterol in the tumor microenvironment and therapy ...
Panpan Xue, Tingjie Bai, Huilan Zhuang, Angelo H. All, Shuangqian Yan, Xuemei Zeng   +5 more
wiley   +1 more source

Sulforaphane attenuates CD36-mediated platelet hyperreactivity through modulating cAMP/PKA/NOX2 signaling in hyperlipidemic conditions

Food Science and Human Wellness
Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidized low-density
Weiqi Li, Chunting Wu, Xinyu Zhou, Xinhui Huang, Chunmei Zhang, Yongjie Ma, Jinqiu Hu, Xiaoyan Bi, Junyu Ma, Mengyao Li, Dong Lu, Liang Hu, Jiahua Fan, Fuli Ya   +13 more
doaj   +1 more source

PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis [PDF]

, 2019
Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis‐associated AKI are poorly understood.
Bennion, Brock G, Djukovic, Danijel, Fei, Lin, Iwaki, Takuma, Liles, W. Conrad, Lynn, Jared C, Otinga, Cynthia, Raftery, Daniel, Standage, Stephen W, Stenson, Erin K, Wong, Hector R   +10 more
core   +2 more sources

Computer‐Aided Functional Oligosaccharide Screening and the Regulatory Role in Lipid Metabolism

Food Bioengineering, EarlyView.
ABSTRACT This study investigated the lipid‐lowering effects and intervention mechanisms of structurally diverse functional oligosaccharides on non‐alcoholic fatty liver disease (NAFLD). By integrating computational tools such as molecular docking and molecular dynamics simulations (MDS), a comprehensive “in silico‐in vitro‐in vivo” tri‐dimensional ...
Rui Jing, Shanshan Deng, Mengyao Zhao, Liming Zhao   +3 more
wiley   +1 more source

Maintenance of Carnitine Homeostasis as a Therapeutic Strategy to Attenuate Cisplatin‐Induced Acute Kidney Injury

Food Frontiers, EarlyView.
ABSTRACT Acute kidney injury (AKI) has emerged as a significant global public health concern due to its high morbidity and mortality rates. Cisplatin, a highly effective and widely used chemotherapeutic agent, is often limited in clinical application by its nephrotoxicity, particularly AKI.
Mingkang Zhang, Yazhi Wang, Xiujuan Wang, Yan Zhou, Yanrong Ma, Xin'an Wu   +5 more
wiley   +1 more source

Unpacking and understanding the impact of proprotein convertase subtilisin/kexin type 9 inhibitors on apolipoprotein B metabolism [PDF]

, 2017
No abstract ...
Packard, Chris J.
core   +1 more source

Gut Microbiota–Metabolism Axis Shapes the Individual Metabolic Phenotype of Different Microbiota‐Accessible Carbohydrates

Food Frontiers, EarlyView.
Specific MAC bioactivities are associated with gut biotransformation. ABSTRACT Increasing the intake of microbiota‐accessible carbohydrates (MACs) has emerged as a promising nutritional strategy for preventing metabolic diseases. However, the consistency of their beneficial effects remains unclear, hindering their optimized application.
Na‐Na Zhang, Guo‐Quan Shao, Xin‐Xin Guo, Jing‐Yi Zhang, Yang Li, Li‐Li Wang, Yue Zhang, Feng‐Zhong Wang, Li‐Tao Tong   +8 more
wiley   +1 more source

Comparative Studies of Vertebrate Platelet Glycoprotein 4 (CD36)

Biomolecules, 2012
Platelet glycoprotein 4 (CD36) (or fatty acyl translocase [FAT], or scavenger receptor class B, member 3 [SCARB3]) is an essential cell surface and skeletal muscle outer mitochondrial membrane glycoprotein involved in multiple functions in the body. CD36
Roger S. Holmes
doaj   +1 more source

CD36 promotes the epithelial–mesenchymal transition and metastasis in cervical cancer by interacting with TGF-β

Journal of Translational Medicine, 2019
Background Accumulating evidence indicates that CD36 initiates metastasis and correlates with an unfavorable prognosis in cancers. However, there are few reports regarding the roles of CD36 in initiation and metastasis of cervical cancer.
Min Deng, Xiaodong Cai, Ling Long, Linying Xie, Hongmei Ma, Youjian Zhou, Shuguang Liu, Chao Zeng   +7 more
doaj   +1 more source