Results 31 to 40 of about 77,752 (295)

The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration? [PDF]

, 2017
Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid laden macrophages (LLM) within the airway may indicate aspiration secondary to GOR.
Adams, Ahrens, Anderson, Greenman, Nakahira, Pacheco-Galván, Porcheray   +6 more
core   +2 more sources

Offspring subcutaneous adipose markers are sensitive to the timing of maternal gestational weight gain [PDF]

, 2015
peer-reviewedBackground Excessive maternal weight gain during pregnancy impacts on offspring health. This study focused on the timing of maternal gestational weight gain, using a porcine model with mothers of normal pre-pregnancy weight.
Berry, Donagh, Blancher, Florence, Castaneda-Gutierrez, Euridice, Darimont, Christian, Giblin, Linda, Lawlor, Peadar G, Leone, Patricia, McNamara, Louise B.   +7 more
core   +1 more source

GLP-1(7-36) inhibits atherosclerosis progression in ApoE-/- mouse aorta by lowering expressions of CD36 and ACAT1 in foam cells

Di-san junyi daxue xuebao, 2019
Objective To investigate whether glucagon-like peptide-1 (GLP-1) (7-36) inhibits the progression of aortic atherosclerotic plaque in ApoE knockout (ApoE-/-) mice fed with high-fat diet and the effect of GLP-1 (7-36) on the expressions of CD36 and acyl ...
HAN Yongkui, YUE Yunfei, ZHANG Kui, SHEN Xiaoyu   +3 more
doaj   +1 more source

CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice

Translational Psychiatry, 2021
Both inflammatory processes and gut microbiota have been implicated in the pathophysiology of depressive disorders. The class B scavenger receptor CD36 is involved in the cytotoxicity associated with inflammation.
Shunjie Bai, Wei Wang, Ting Wang, Juan Li, Shuxiao Zhang, Zhi Chen, Xunzhong Qi, Jianjun Chen, Ke Cheng, Peng Xie   +9 more
doaj   +1 more source

Role of CD36 in cancer progression, stemness, and targeting

Frontiers in Cell and Developmental Biology, 2022
CD36 is highly expressed in diverse tumor types and its expression correlates with advanced stages, poor prognosis, and reduced survival. In cancer cells, CD36: 1) increases fatty acid uptake, reprogramming lipid metabolism; 2) favors cancer cell ...
Sandra L. Guerrero-Rodríguez, Cecilia Mata-Cruz, Cecilia Mata-Cruz, Sonia M. Pérez-Tapia, Sonia M. Pérez-Tapia, Sonia M. Pérez-Tapia, Marco A. Velasco-Velázquez   +6 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

CD36 contributes to malaria parasite-induced pro-inflammatory cytokine production and NK and T cell activation by dendritic cells. [PDF]

PLoS ONE, 2013
The scavenger receptor CD36 plays important roles in malaria, including the sequestration of parasite-infected erythrocytes in microvascular capillaries, control of parasitemia through phagocytic clearance by macrophages, and immunity.
Nagaraj M Gowda, Xianzhu Wu, Sanjeev Kumar, Maria Febbraio, D Channe Gowda   +4 more
doaj   +1 more source

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor. [PDF]

, 2016
Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity.
Bakirtzi, K, Cheng, M, Fisseha, E, Fleshner, P, Gallo, RL, Hing, TC, Ho, S, Hoang-Ngoc Tran, D, Hoang-Yen Tran, D, Karagiannides, I, Koon, HW, Law, I, Lee, EC, Lee, JE, Li, Z, Mattai, SA, McGovern, DPB, Ortiz, C, Robbins, L, Sallam, T, Shieh, C, Shih, DQ, Sideri, A, Su, B, Targan, SR, Vu, M   +25 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

DPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation

Drug Design, Development and Therapy, 2020
Haoran Wang,1 Yue Li,2 Xiaoliang Zhang,2 Zhonglin Xu,2 Jianzhong Zhou,3 Wei Shang2 1Department of Endocrinology, The Ninth People’s Hospital of Chongqing, Chongqing 400700, People’s Republic of China; 2Department of Cardiology, The Ninth ...
Wang H, Li Y, Zhang X, Xu Z, Zhou J, Shang W   +5 more
doaj