Results 61 to 70 of about 71,651 (313)

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

CD36-mediated podocyte lipotoxicity promotes foot process effacement

Open Medicine
Lipid metabolism disorders lead to lipotoxicity. The hyperlipidemia-induced early stage of renal injury mainly manifests as podocyte damage. CD36 mediates fatty acid uptake and the subsequent accumulation of toxic lipid metabolites, resulting in podocyte
Hua Wei, Peng Lan, Chen Xue-mei, Jiang XuShun, Hu JianGuo, Jiang Xian-Hong, Xiang Xu, Wan Jiangmin, Long Yingfei, Xiong Jianqiong, Ma Xueyi, Du Xiaogang   +11 more
doaj   +1 more source

Assignment of disulfide bridges in bovine CD36 [PDF]

European Journal of Biochemistry, 1998
The multifunctional membrane protein CD36 is expressed on platelets, mature monocytes and macrophages, microvascular endothelial cells and mammary epithelial cells. The exact physiological function of this glycoprotein is unclear. In order to determine the number and pattern of disulfide bridges, CD36 was purified from bovine milk fat globule membranes.
Rasmussen, Jan T., Berglund, Lars, Rasmussen, Margit S., Petersen, Torben E.   +3 more
openaire   +4 more sources

Electrochemistry‐Based Assay for Monitoring of Adherent Macrophages and Foam Cells on Ab‐CD36 Modified Electrospun Nanofibers

Advanced Materials Interfaces, EarlyView.
Here, for the first time, macrophages and foam cells' adhesions to the developed polystyrene/graphene oxide‐3‐aminopropyltriethoxysilane/Anti‐CD36 (PS@GAPTES@Ab‐CD36) electrospun nanofiber‐based biofunctional surface using electrochemical measurements and fluorescence imaging are examined.
Simge Er Zeybekler, Ahmet Çifçi, Diğdem Yöyen Ermiş, Gözde Arslan, Haluk Barbaros Oral, Dilek Odaci   +5 more
wiley   +1 more source

Molecular Mechanism and Therapeutic Exploration of CD36 in Breast Cancer

Zhongliu Fangzhi Yanjiu
Breast cancer is the most diagnosed cancer in women worldwide and the leading cause of most cancer-related deaths, posing a serious threat to women′s health worldwide.
FU Shengqiao, JI Qian, SUN Xinyu, PU Xi, WU Yuting, TANG Haowei, SHENG Wanying, WANG Xu   +7 more
doaj   +1 more source

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis

Cell Death and Disease, 2021
Metabolic reprogramming is a new hallmark of cancer but it remains poorly defined in hepatocellular carcinogenesis (HCC). The fatty acid receptor CD36 is associated with both lipid and glucose metabolism in the liver.
Xiaoqing Luo, Enze Zheng, Li Wei, Han Zeng, Hong Qin, Xiaoyu Zhang, Meng Liao, Lin Chen, Lei Zhao, Xiong Z. Ruan, Ping Yang, Yaxi Chen   +11 more
doaj   +1 more source

Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation

Advanced Science, EarlyView.
Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu, Tong Ji, Zhichao Ye, Jianing Yan, Chao Wang, Jiachen Chen, Ziyang Jin, Yongji Zhu, Xiujun Cai, Yifan Wang   +9 more
wiley   +1 more source

Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice.

PLoS ONE, 2010
CD36 facilitates oxidized low density lipoprotein uptake and is implicated in development of atherosclerotic lesions. CD36 also binds unmodified high and very low density lipoproteins (HDL, VLDL) but its role in the metabolism of these particles is ...
Pin Yue, Zhouji Chen, Fatiha Nassir, Carlos Bernal-Mizrachi, Brian Finck, Salman Azhar, Nada A Abumrad   +6 more
doaj   +1 more source