Results 91 to 100 of about 16,779 (207)

Inhibition of endothelial activation: a new way to treat cerebral malaria? [PDF]

, 2005
BACKGROUND: Malaria is still a major public health problem, partly because the pathogenesis of its major complication, cerebral malaria (CM), remains incompletely understood.
Cianciolo, George J, Combes, Valéry, Grau, Georges E, Wassmer, Samuel C   +3 more
core   +4 more sources

Region‐Specific CD16+ Neutrophils Promote Colorectal Cancer Progression by Inhibiting Natural Killer Cells

Advanced Science
The colon is the largest compartment of the immune system, with innate immune cells exposed to antigens in the environment. However, the mechanisms by which the innate immune system is instigated are poorly defined in colorectal cancer (CRC).
Yan Zhang, Zien Wang, Yu Lu, David J. Sanchez, Jiaojiao Li, Linghao Wang, Xiaoxue Meng, Jianjun Chen, Tran Trung Kien, Ming Zhong, Wei‐Qiang Gao, Xianting Ding   +11 more
doaj   +1 more source

A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis? [PDF]

, 2012
Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages.
Allen, JT, Anthony, BJ, Li, Y, McManus, D   +3 more
core   +4 more sources

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Infectivity of Plasmodium falciparum in malaria-naive individuals is related to knob expression and cytoadherence of the parasite [PDF]

, 2016
Plasmodium falciparum is the most virulent human malaria parasite because of its ability to cytoadhere in the microvasculature. Nonhuman primate studies demonstrated relationships among knob expression, cytoadherence, and infectivity.
Beeson, James G., Chan, Jo-Anne A., Fink, James, Gerrard, John, Good, Michael F., Griffin, Paul M., Hackett, Hazel, Hanssen, Eric, Hoffman, Stephen L., Langer, Christine, Liu, Xue Q., McCarthy, James S., Pingnet, Jolien, Rodriguez, Ingrid B., Sekuloski, Silvana, Stanisic, Danielle I., Sundac, Lana, Trenholme, Katharine R., Wang, Claire Y. T., Yang, Yuedong, Zhou, Yaoqi   +20 more
core   +1 more source

Antenatal betamethasone impairs markers of cardiac development and function in near‐term lambs

Experimental Physiology, EarlyView.
Abstract figure Summary of key molecular differences in the left ventricle of near‐term lambs exposed to antenatal betamethasone, compared to saline. Pregnant ewes received two doses of either saline (Saline) or betamethasone (Betamethasone, intramuscular, 11.4 mg) given 24 h apart, before delivery at 140 days of gestation (dG, term = 150 dG).
Reza Amanollahi, Ashley S. Meakin, Stacey L. Holman, Vicki L. Clifton, Kent L. Thornburg, Michael D. Wiese, Kathryn L. Gatford, Mitchell C. Lock, Janna L. Morrison   +8 more
wiley   +1 more source

Induction of CD36 and Thrombospondin-1 in Macrophages by Hypoxia-Inducible Factor 1 and Its Relevance in the Inflammatory Process [PDF]

, 2012
Inflammation is part of a complex biological response of vascular tissue to pathogens or damaged cells. First inflammatory cells attempt to remove the injurious stimuli and this is followed by a healing process mediated principally by phagocytosis of ...
Barrachina Sancho, María Dolores, Calatayud Romero, Sara, Cosín Roger, Jesús, Díez, Irene, Esplugues Mota, Juan Vicente, Hernández, Carlos, Ortiz Masiá, María Dolores   +6 more
core   +2 more sources

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Microvascular endothelial cells express a phosphatidylserine receptor: a functionally active receptor for phosphatidylserine-positive erythrocytes [PDF]

, 2007
Phosphatidylserine (PS)-positive erythrocytes adhere to endothelium and subendothelial matrix components. While thrombospondin mediates these inter-actions, it is unknown whether PS-associated erythrocyte-endothelial adhesion occurs in the absence of ...
Betal, Suhita Gayen, Setty, Yamaja
core   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source