Results 91 to 100 of about 1,186,345 (240)

CD36 c.1264 T>G Null Mutation Impairs Acquisition of IgG Antibodies to Plasmodium falciparum MSP1‐₁₉ Antigen and is Associated with Higher Malaria Incidences in Tanzanian Children [PDF]

Scandinavian Journal of Immunology, 2012
AbstractPolymorphisms in genes that encode crucial signalling molecules have been proposed as factors that influence susceptibility to, and outcome of malaria. We studied the role of a mutation, c.1264 T>G, that causes CD36 deficiency on IgG responses to MSP‐119 antigen and malaria incidence. Children were genotyped for the c.1264 T>G mutation at
D, Kajeguka, C, Mwanziva, M, Daou, A, Ndaro, S, Matondo, E, Mbugi, W, Dolmans, J, Chilongola   +7 more
openaire   +2 more sources

Genetic polymorphisms linked to susceptibility to malaria [PDF]

, 2011
The influence of host genetics on susceptibility to Plasmodium falciparum malaria has been extensively studied over the past twenty years. It is now clear that malaria parasites have imposed strong selective forces on the human genome in endemic regions.
Adel Driss, Jacqueline M Hibbert, Nana O Wilson, Shareen A Iqbal, Thomas V Adamkiewicz, Jonathan K Stiles   +5 more
core   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Tributyltin Protumorigenic Effects Targeting Prostate Cancer Cell Metabolism, Proliferation, Migration, and Invasion

Environmental Toxicology, EarlyView.
ABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Mariana Feijó, Luís P. Brás, Catarina M. D. Serra, Lara R. S. Fonseca, Sara Correia, Bruno J. Pereira, Ana P. Duarte, Henrique J. Cardoso, Cátia V. Vaz, Sílvia Socorro   +9 more
wiley   +1 more source

Schistosoma japonicum infection causes a reprogramming of glycolipid metabolism in the liver

Parasites & Vectors, 2019
Background Recent investigations indicate that schistosome infection is closely associated with aberrant glycolipid metabolism. However, the actual glycolipid metabolism gene expression, as well as the possible pathways that regulate glycolipid ...
Zhi-Peng Xu, Hao Chang, Yang-Yue Ni, Chen Li, Lin Chen, Min Hou, Min-Jun Ji   +6 more
doaj   +1 more source

Defining genome-wide expression and phenotypic contextual cues in macrophages generated by GM-CSF, M-CSF and heat-killed mycobacteria [PDF]

, 2017
Heat-killed (HK) Mycobacterium obuense (NCTC13365) is currently being evaluated in the clinic as an immunotherapeutic agent for cancer treatment. Yet, the molecular underpinnings underlying immunomodulatory properties of HK M.
Charles Akle, Emale El-Darzi, Georges M. Bahr, Helmout Modjtahedi, Humam Kadara, Marcel Achkar, Samer Bazzi, Samer Bazzi, Satvinder Mudan, Tina McDowell   +9 more
core   +3 more sources

Growth differentiation factor 15 mitigates lipotoxic steatosis by preserving mitochondrial morphodynamics and augmenting fatty acid oxidation in hepatocytes and liver organoids

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Growth differentiation factor 15 (GDF15) has emerged as a promising metabolic regulator with hepatoprotective properties in metabolic dysfunction‐associated steatotic liver disease (MASLD), yet its underlying mechanisms remain elusive.
Jia Li, Qi Zhou, Mengmeng Xia, Yakun Li, Junyu Wang, Manon Buist‐Homan, Vincent E. de Meijer, Hans Blokzijl, Klaas Nico Faber, Han Moshage   +9 more
wiley   +1 more source

Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease. [PDF]

, 2014
The etiology of persistent lung inflammation in preterm infants with chronic lung disease of prematurity (CLD) is poorly characterized, hampering efforts to stratify prognosis and treatment. Airway macrophages are important innate immune cells with roles
A Kotiranta-Ainamo, AE Currie, BJ Zeligs, BJ Zeligs, BW Kramer, BW Parks, C Haslett, D Chantry, David H. Dockrell, DH Bowden, E Alenghat, E Forster-Waldl, Eamon P. McGreal, ER Unanue, F Genel, F Kanakoudi-Tsakalidou, G Fingerle, G Kurland, H Arai, HM Marriott, HW Ziegler-Heitbrock, HW Zimmermann, HY Huh, Ian Sabroe, J Grigg, J Savill, JA Bellanti, JM Cavaillon, JM Grigg, K Asada, K Dhaliwal, L Landsman, L Ziegler-Heitbrock, LJ Van Marter, Lynne R. Prince, M Daigneault, M Iwahashi, M Zhang, ML Huynh, Moira K. Whyte, NE Alexis, Nicola C. Maxwell, NS Dessardo, O Grip, Oliver Eickelberg, P Antal-Szalmas, PL Davies, R Andreesen, RL Kradin, S Knapp, S Kotecha, S Kotecha, S Rosseau, SA Renshaw, Sailesh Kotecha, SB Gordon, Sharonjit K. Gill, T Ganz, TS Blackwell, U Hallwirth, VA Fadok, WS Driscoll   +61 more
core   +4 more sources

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

High levels of serum cholesterol increase the risk of developing vessel co‐opting tumors in colorectal cancer liver metastases

The FEBS Journal, EarlyView.
High serum cholesterol is linked to colorectal cancer liver metastases (CRCLM) subtypes with poor survival (replacement pattern). Levels of cholesterol under 4 mmol·L−1 correlated with better survival and a desmoplastic pattern subtype. Furthermore, in vivo PCSK9 inhibitor evolocumab, which lowers cholesterol, reduced liver metastases.
Amatzia Gantz, Audrey Kapelanski‐Lamoureux, Miran Rada, Lucyna Krzywon, Migmar Tsamchoe, Anastasia Tsatoumas, Stephanie K. Petrillo, Nabil G. Seidah, Anthoula Lazaris, Peter Metrakos   +9 more
wiley   +1 more source