Results 101 to 110 of about 16,779 (207)

The role of apoptosis proteins and complement components in the etiopathogenesis of systemic lupus erythematosus [PDF]

, 2010
Systemic lupus erythematosus is a prototypical autoimmune disease characterized by the deregulation of T and B cells, tissue infiltration by mononuclear cells, tissue damage and the production of autoantibodies.
KISS, Maria Helena Bittencourt, LIPHAUS, Bernadete L.   +1 more
core   +5 more sources

Extracellular Vesicles: Biology, Intercellular Communication and Therapeutic Potential in Diabetes

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Exosome packaging in diabetes mellitus is depicted. Induced expression levels of RBP4, WNT related proteins, TGFB1, BMPs, VEGFs, STAT3, Calpain2 and altered expression levels of microRNAs in the exosomes are responsible for the inflammatory actions, defective central metabolism, myofibroblasts proliferation, dysregulated cell migration, cell ...
Swayam Prakash Srivastava, Lydia Herrmann, Eden Ozkan, Abhiram Kunamneni, Vinamra Swaroop, Geetika Nehra, Rohit Srivastava, Pratima Tripathi, Ken Inoki, Julie E. Goodwin   +9 more
wiley   +1 more source

Cadherin‐26 Facilitates Transepithelial Migration of Eosinophils in Eosinophilic Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, Volume 16, Issue 2, Page 138-151, February 2026.
ABSTRACT Background Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by persistent sinonasal inflammation and marked eosinophilic infiltration. Although the relationship between eosinophils and NP formation has been extensively studied, the mechanisms governing eosinophil transepithelial migration into the nasal mucosa ...
Yeong‐In Jo, Jee Won Moon, Joo‐Hoo Park, Hwa Eun Yang, Subin Cho, Hyeongguk Son, Hyun‐Woo Yang, Il‐Ho Park   +7 more
wiley   +1 more source

Generation and characterization of iPSC‐derived microglia for in vitro modeling of stimuli‐specific neuroimmune responses

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Microglia are macrophage‐like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derived microglia cell culture model for use in neuroimmune modeling and therapeutic testing.
Angela K. Haskell, Joshua A. Kulas, William E. Carter, June Javens‐Wolfe, Raven Dance Hinkel, Mustapha Moussaif, Jacob S. Smiley, Olivia Lazaro, Sylvia Robertson, Alan D. Palkowitz, Bruce T. Lamb, Timothy I. Richardson, Jeffrey L. Dage, Shaoyou Chu, Travis Johnson, Louis F. Stancato, Abdul Qadir Syed   +16 more
wiley   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. [PDF]

, 2018
Oxidized phospholipids (OxPL) are ubiquitous, are formed in many inflammatory tissues, including atherosclerotic lesions, and frequently mediate proinflammatory changes 1 .
Binder, Christoph J, Bowden, Karen, Diehl, Cody, Gaddis, Dalia E, Glass, Christopher K, Gonen, Ayelet, Hedrick, Catherine C, Hung, Ming-Yow, Ley, Klaus, MacDonald, Jeffrey G, Mellon, Pamela L, Miller, Yury I, Määttä, Antti, Pattison, Jennifer, Peterson, Kirk L, Prohaska, Thomas A, Que, Xuchu, Sun, Xiaoli, Tsimikas, Sotirios, Witztum, Joseph L, Yeang, Calvin, Ylä-Herttuala, Seppo   +21 more
core   +1 more source

Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements

European Journal of Immunology, Volume 56, Issue 2, February 2026.
A deeper understanding of the natural killer cell gene expression regulation driving NK cell maturation and cytotoxicity could provide critical insights into optimizing NK therapies. Our findings reveal novel enhancers governing NK cell genes for NCAM1/CD56 and cis‐regulation for KIR receptors and clarify existing models of NK cell cis‐accessibility ...
Mariam A. Salem, Aditi Varkey, Matthew D. Estrada, Kruthika Sharma, Caprice D. Eisele, Nitin Chakravarti, Dean A. Lee, Aharon G. Freud, Bethany L. Mundy‐Bosse, Patrick L. Collins   +9 more
wiley   +1 more source

Prognostic value of flow cytometry in myelodysplastic neoplasms (MDS): Composition of a FCM‐prognostic score (FCM‐PS) for overall survival

HemaSphere, Volume 10, Issue 2, February 2026.
Abstract Flow cytometry (FCM) is a co‐criterion in myelodysplastic neoplasms (MDS) diagnostics, currently not used for prognostication. This study aimed to develop an FCM‐score predicting overall survival (OS) in MDS to improve early clinical patient prognostication.
Aida Santaolalla, Uta Oelschlaegel, Susann Winter, Shirin Jamshidi, Theresia M. Westers, Katja Sockel, Martin Bornhäuser, Rosa Andres Ejarque, Farzin Farzaneh, Antonella Poloni, Anne‐Sophie Kubasch, Mieke Van Hemelrijck, Arjan A. van de Loosdrecht, Uwe Platzbecker, Shahram Kordasti   +14 more
wiley   +1 more source

Age-related changes to lumbosacral spinal cord motoneurons that modulate bladder and bowel functions in male C57BL/6 mice [PDF]

, 2013
Incontinence and sexual dysfunction are often increased in the aged human population. In rats and mice the pattern of micturition and faecal clearance also changes with ageing and is suggestive of bladder and bowel ...
Black, G., Ranson, R. N, Saffrey, M. J., Tsang, H., Zhang, M.   +4 more
core  

The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection. [PDF]

, 2017
During Plasmodium falciparum infections, erythrocyte-stage parasites inhibit dendritic cell maturation and function; compromising development of effective anti-malarial adaptive immunity. Human Vγ9Vδ2 T-cells can act in vitro as APCs and induce αβ T-cell
Behr, Charlotte, Duluc, Dorothée, Duvignaud, Alexandre, Déchanet-Merville, Julie, Eberl, Matthias, Howard, Jennifer, Loizon, Séverine, Malvy, Denis, Mamani-Matsuda, Maria, Mechain, Matthieu, Mercereau-Puijalon, Odile, Moreau, Jean-Francois, Moser, Bernhard, Troye-Blomberg, Marita, Tyler, Christopher J.   +14 more
core   +2 more sources