Oxidation by neutrophils-derived HOCl increases immunogenicity of proteins by converting them into ligands of several endocytic receptors involved in antigen uptake by dendritic cells and macrophages. [PDF]
PLoS ONE, 2015 The initiation of adaptive immune responses to protein antigens has to be preceded by their uptake by antigen presenting cells and intracellular proteolytic processing.
Rafał Biedroń +3 more
doaj +1 more source
Regulation of T cell expansion by antigen presentation dynamics [PDF]
PNAS 2019, 116 (13) 5914-5919, 2018 An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells. This proliferation must be regulated to ensure an effective response to infection while avoiding immunopathology.
arxiv +1 more source
The regulation of B cell responses in systemic autoimmunity [PDF]
, 2017 Our immune system is a complex network made up of physical barriers and specialized proteins, cells and organs that all work together to prevent pathogens from causing disease in the body.
Duhlin, Amanda
core +1 more source
A case of platelet transfusion refractoriness due to anti-CD36 with a successful treatment outcome
Immunohematology, 2019 Antibodies (Abs) against antigens on platelets (PLTs), including glycoprotein IV (CD36), can cause PLT refractoriness. Transfusing PLTs to patients with anti-CD36 is challenging because of the rarity of CD36-negative (CD36–) donors and the possibility of
S. Khatri, B. Curtis, C. Yamada
semanticscholar +1 more source
Impact of intermittent preventive anti-malarial treatment on the growth and nutritional status of preschool children in rural Senegal (west Africa). [PDF]
, 2007 Negative consequences of malaria might account for seasonality in nutritional status in children in the Sahel. We report the impact of a randomized, double-blind, placebo-controlled trial of seasonal intermittent preventive anti-malarial treatment on ...
Alexander, Neal +10 more
core +2 more sources
Nutrients, 2022 As of late, evidence has been emerging that the Maillard reaction (MR, also referred to as glycation) affects the structure and function of food proteins.
Daniela Briceno Noriega +7 more
semanticscholar +1 more source
Redox Biology, 2021 Macrophages are innate immune cells that internalize and present exogenous antigens to T cells via MHC class II proteins. They operate at sites of infection in a highly inflammatory environment, generated in part by reactive oxygen species, in particular
Agnes Ulfig +5 more
doaj
Molecular tug of war reveals adaptive potential of an immune cell repertoire [PDF]
arXiv, 2022 The adaptive immune system constantly remodels its lymphocyte repertoire for better protection against future pathogens. Its ability to improve antigen recognition on the fly relies on somatic mutation and selective expansion of B lymphocytes expressing high-affinity antigen receptors.
arxiv
The role of Plasmodium falciparum var genes in malaria in pregnancy [PDF]
, 2004 Sequestration of Plasmodium falciparum-infected erythrocytes in the placenta is responsible for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result of parasite adhesion molecules expressed on the surface of infected ...
Andrews +51 more
core +1 more source
CD24, CD27, CD36 and CD302 gene expression for outcome prediction in patients with multiple myeloma
OncoTarget, 2017 Multiple myeloma (MM) is a B cell neoplasia characterized by clonal plasma cell (PC) proliferation. Minimal residual disease monitoring by multi-parameter flow cytometry is a powerful tool for predicting treatment efficacy and MM outcome.
E. Alaterre +10 more
semanticscholar +1 more source