Results 51 to 60 of about 1,031,952 (237)

IFN-γ production by brain-resident cells activates cerebral mRNA expression of a wide spectrum of molecules critical for both innate and T cell-mediated protective immunity to control reactivation of chronic infection with Toxoplasma gondii

Frontiers in Cellular and Infection Microbiology, 2023
We previously demonstrated that brain-resident cells produce IFN-γ in response to reactivation of cerebral infection with Toxoplasma gondii. To obtain an overall landscape view of the effects of IFN-γ from brain-resident cells on the cerebral protective ...
Yasuhiro Suzuki, Jenny Lutshumba, Kuey Chu Chen, Kuey Chu Chen, Mohamed H. Abdelaziz, Qila Sa, Eri Ochiai   +6 more
doaj   +1 more source

The microglial "activation" continuum: from innate to adaptive responses [PDF]

, 2005
Microglia are innate immune cells of myeloid origin that take up residence in the central nervous system (CNS) during embryogenesis. While classically regarded as macrophage-like cells, it is becoming increasingly clear that reactive microglia play more ...
Nikolic, Veljko, Tan, Jun, Town, Terrence   +2 more
core   +3 more sources

Functions of two distinct Kupffer cells in the liver

Exploration of Medicine, 2021
Tissue-resident macrophages play critically important roles in host homeostasis and pathogenesis of diseases, with the functions of phagocytosis, metabolism, and immune modulation.
Chunye Zhang, Shuai Liu, Ming Yang
doaj   +1 more source

Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy

Retrovirology, 2008
Background The efficacy of highly active antiretroviral therapy (HAART) determined by simultaneous monitoring over 100 cell-surface antigens overtime has not been attempted.
Wang Bin, Belov Larissa, Chrisp Jeremy, Dyer Wayne B, Wu Jing, Saksena Nitin K   +5 more
doaj   +1 more source

Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface antigen subsets [PDF]

, 2018
Variant surface antigens (VSAs) play a critical role in severe malaria pathogenesis. Defining gaps, or “lacunae”, in immunity to these Plasmodium falciparum antigens in children with severe malaria would improve our understanding of vulnerability to ...
A Bengtsson, A Claessens, A Djimde, A Salanti, A Salanti, BP Goncalves, C Lessa-Aquino, CI Newbold, CJ Treutiger, CW Wang, D Coulibaly, DH Davies, DI Baruch, F Lennartz, GI Bertin, GK Cham, GM Warimwe, HM Kyriacou, JA Chan, JA Chan, JD Smith, JT Griffin, K Marsh, KE Lyke, KE Lyke, L Turner, M Avril, M Fried, MA Travassos, MA Travassos, MJ Gardner, PD Crompton, RW Snow, S Gupta, SC Murphy, Severe falciparum malaria, SJ Rogerson, SS Oh, T Lavstsen, TE Taylor, TW Mwangi, XZ Su, Y Zhang   +42 more
core   +2 more sources

The regulation of B cell responses in systemic autoimmunity [PDF]

, 2017
Our immune system is a complex network made up of physical barriers and specialized proteins, cells and organs that all work together to prevent pathogens from causing disease in the body.
Duhlin, Amanda
core   +1 more source

The role of Plasmodium falciparum var genes in malaria in pregnancy [PDF]

, 2004
Sequestration of Plasmodium falciparum-infected erythrocytes in the placenta is responsible for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result of parasite adhesion molecules expressed on the surface of infected ...
Andrews, Baruch, Beeson, Beeson, Beeson, Brabin, Buffet, Chen, Costa, Creasey, Dorman, Duffy, Duffy, Flick, Freitas-Junior, Fried, Fried, Fried, Fried, Gardner, Jensen, Kyes, Kyes, Lekana Douki, McCormick, McGregor, Menendez, Menendez, Nosten, O'Neil-Dunne, Reeder, Reeder, Ricke, Rowe, Rowe, Salanti, Salanti, Shulman, Smith, Smith, Smith, Smith, Staalsoe, Staalsoe, Steketee, Su, Suguitan, Taylor, Taylor, Walter, Ward, Winter   +51 more
core   +1 more source

DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown [PDF]

, 2011
Damage-associated molecular patterns (DAMPs) or cell death associated molecular patterns (CDAMPs) are a subset of endogenous intracellular molecules that are normally hidden within living cells but become either passively released by primary and ...
Agostinis, Patrizia, Garg, Abhishek D, Krysko, Dmitri, Vandenabeele, Peter   +3 more
core   +1 more source

Impact of intermittent preventive anti-malarial treatment on the growth and nutritional status of preschool children in rural Senegal (west Africa). [PDF]

, 2007
Negative consequences of malaria might account for seasonality in nutritional status in children in the Sahel. We report the impact of a randomized, double-blind, placebo-controlled trial of seasonal intermittent preventive anti-malarial treatment on ...
Alexander, Neal, Boulanger, Denis, Cissé, Badara, Greenwood, Brian M, Lines, Jo, Ntab, Balthazar, Simondon, François, Simondon, Kirsten B, Sokhna, Cheikh, Targett, Geoffrey, Trape, Jean-François   +10 more
core   +2 more sources

Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia [PDF]

, 2014
Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although mechanisms of BCR/ABL1-induced transformation are well-defined, little is known about effector-molecules contributing to malignant expansion and ...
Bilban, Martin, Blatt, Katharina, Cerny-Reiterer, Sabine, Herndlhofer, Susanne, Herrmann, Harald, Hoermann, Grego, Holyoake, Tessa L., Mannhalter, Christine, Mayerhofer, Matthias, Rulicke, Thomas, Sadovnik, Irina, Sperr, Wolfgang R., Stefanzl, Gabriele, Streubel, Berthold, Valent, Peter, Willmann, Michael   +15 more
core   +1 more source