The influence of host genetics on erythrocytes and malaria infection: is there therapeutic potential? [PDF]
As parasites, Plasmodium species depend upon their host for survival. During the blood stage of their life-cycle parasites invade and reside within erythrocytes, commandeering host proteins and resources towards their own ends, and dramatically ...
Burgio, Gaetan+3 more
core +1 more source
CD38‐Targeting Peptide Vaccine Ameliorates Aging‐Associated Phenotypes in Mice
Shangcheng Yu et al. revealed that CD38‐targeting peptide vaccine ameliorated aging‐associated physical and cognitive phenotypes in mice. CD38‐vaccine selectively depletes CD38+ myeloid cells, improves glucose tolerance, and enhances oxygen consumption.
Shangcheng Yu+10 more
wiley +1 more source
MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo [PDF]
Purpose: Milk fat globule-epidermal growth factor-factor VIII (MFGE8) is necessary for diurnal outer segment phagocytosis and promotes VEGF-dependent neovascularization.
A Swaroop+52 more
core +7 more sources
This study investigates the intratumoral heterogeneity (ITH) in osteosarcoma by analyzing paired tumor tissue samples from the central and peripheral regions of six patients using single‐cell RNA sequencing. The findings reveal significant microenvironmental differences, with the central region enriched in immune cells and the peripheral region ...
Zhehao Dai+7 more
wiley +1 more source
Schematic diagram illustrating the molecular mechanisms of the Cx3cl1‐Cx3cr1 axis mediated by rTMS activation of GABAergic neurons in the process of cognitive function recovery in AD. ABSTRACT This study aimed to investigate the impact of repetitive transcranial magnetic stimulation (rTMS) on cognitive recovery in Alzheimer's disease (AD) by exploring ...
Yunxiao Kang+7 more
wiley +1 more source
Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes. [PDF]
Parasite-encoded variant surface antigens (VSAs) like the var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic variation and infected red blood cell (RBC) cytoadhesion in P.
Chiucchiuini, Antonella+16 more
core +5 more sources
Spontaneous Remission of Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report
Spontaneous remissions (SRs) in blastic plasmacytoid dendritic cell neoplasms (BPDCNs) are infrequent, poorly documented, and transient. We report a 40-year-old man presenting with bycitopenia and soft tissue infection.
Tamara Castaño-Bonilla+8 more
doaj +1 more source
Schistosoma japonicum infection causes a reprogramming of glycolipid metabolism in the liver
Background Recent investigations indicate that schistosome infection is closely associated with aberrant glycolipid metabolism. However, the actual glycolipid metabolism gene expression, as well as the possible pathways that regulate glycolipid ...
Zhi-Peng Xu+6 more
doaj +1 more source
Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen+9 more
wiley +1 more source
Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation [PDF]
Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
McCoy, Kathleen L.
core +4 more sources