Results 81 to 90 of about 16,779 (207)

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Spontaneous Remission of Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report

Medicina
Spontaneous remissions (SRs) in blastic plasmacytoid dendritic cell neoplasms (BPDCNs) are infrequent, poorly documented, and transient. We report a 40-year-old man presenting with bycitopenia and soft tissue infection.
Tamara Castaño-Bonilla, Raquel Mata, Daniel Láinez-González, Raquel Gonzalo, Susana Castañón, Francisco Javier Díaz de la Pinta, Carlos Blas, José L. López-Lorenzo, Juan Manuel Alonso-Domínguez   +8 more
doaj   +1 more source

Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. [PDF]

, 2004
Daily phagocytosis by the retinal pigment epithelium (RPE) of spent photoreceptor outer segment fragments is critical for vision. In the retina, early morning circadian photoreceptor rod shedding precedes synchronized uptake of shed photoreceptor ...
Brodie, Scott E, Finnemann, Silvia C, Huang, Xiaozhu, Kim, Yoonhee, Nandrot, Emeline F, Sheppard, Dean   +5 more
core   +1 more source

Capacity strengthening in malaria research: the Gates Malaria Partnership.

, 2006
The Gates Malaria Partnership (GMP) includes five African and four European partner institutions. Its research programme has five priority areas involving an extensive range of field-based studies.
Bhasin, Amit, Bowler, Cathy H, Greenwood, Brian M, Naylor, Heather, Targett, Geoffrey A   +4 more
core   +1 more source

In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate [PDF]

, 2007
Spontaneous binding of infected erythrocytes to uninfected erythrocytes to form rosettes is a property of some strains of Plasmodium falciparum that is linked to severe complications of malaria.
Arman, Monica, Bull, Peter C, Havlik, Ivan, Kyriacou, Helen M, Raza, Ahmed, Rowe, J Alexandra, Steen, Katie E, Warimwe, George   +7 more
core   +2 more sources

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

Schistosoma japonicum infection causes a reprogramming of glycolipid metabolism in the liver

Parasites & Vectors, 2019
Background Recent investigations indicate that schistosome infection is closely associated with aberrant glycolipid metabolism. However, the actual glycolipid metabolism gene expression, as well as the possible pathways that regulate glycolipid ...
Zhi-Peng Xu, Hao Chang, Yang-Yue Ni, Chen Li, Lin Chen, Min Hou, Min-Jun Ji   +6 more
doaj   +1 more source

High levels of serum cholesterol increase the risk of developing vessel co‐opting tumors in colorectal cancer liver metastases

The FEBS Journal, EarlyView.
High serum cholesterol is linked to colorectal cancer liver metastases (CRCLM) subtypes with poor survival (replacement pattern). Levels of cholesterol under 4 mmol·L−1 correlated with better survival and a desmoplastic pattern subtype. Furthermore, in vivo PCSK9 inhibitor evolocumab, which lowers cholesterol, reduced liver metastases.
Amatzia Gantz, Audrey Kapelanski‐Lamoureux, Miran Rada, Lucyna Krzywon, Migmar Tsamchoe, Anastasia Tsatoumas, Stephanie K. Petrillo, Nabil G. Seidah, Anthoula Lazaris, Peter Metrakos   +9 more
wiley   +1 more source

Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae.

, 2001
Combination therapy that includes artemisinin derivatives cures most falciparum malaria infections. Lowering transmission by reducing gametocyte infectivity would be an additional benefit.
Targett, G, Drakeley, C, Jawara, M, von Seidlein, L, Coleman, R, Deen, J, Pinder, M, Doherty, T, Sutherland, C, Walraven, G, Milligan, P   +10 more
core   +1 more source

Defining genome-wide expression and phenotypic contextual cues in macrophages generated by GM-CSF, M-CSF and heat-killed mycobacteria [PDF]

, 2017
Heat-killed (HK) Mycobacterium obuense (NCTC13365) is currently being evaluated in the clinic as an immunotherapeutic agent for cancer treatment. Yet, the molecular underpinnings underlying immunomodulatory properties of HK M.
Charles Akle, Emale El-Darzi, Georges M. Bahr, Helmout Modjtahedi, Humam Kadara, Marcel Achkar, Samer Bazzi, Samer Bazzi, Satvinder Mudan, Tina McDowell   +9 more
core   +3 more sources