Phorbol ester induced ex vivo expansion of rigorously-defined phenotypic but not functional human cord blood hematopoietic stem cells: a cautionary tale demonstrating that phenotype does not always recapitulate stem cell function [PDF]
Broxmeyer, Hal E. +8 more
core +1 more source
Abstract Flow cytometry‐based measurable residual disease (MRD) testing is routinely used in acute myeloid leukemia (AML), but methodologies need refinement to optimize assay characteristics. Here, we examined 1215 adults with AML or myelodysplastic syndrome/AML allografted in morphologic remission to study how the type(s) of leukemic blasts and degree/
Calvin M. Le +8 more
wiley +1 more source
Correlation matrix analysis of lymphocyte parameters. The correlation matrix showed the positive (red) or negative (blue) correlation of two parameters; the color intensity reflected the correlation coefficient. Conducting lymphocyte testing in health management can help monitor immune status, evaluate health risks, analyze pathogenesis of diseases ...
An‐Na Jiang +5 more
wiley +1 more source
Diagnostic sequencing identifies high-risk markers and mechanisms of resistance to guide immunotherapy selection. [PDF]
Sudha P +16 more
europepmc +1 more source
Identification of Extracellular Vesicle Signatures of Daratumumab Treated Multiple Myeloma
Multiple myeloma peripheral blood extracellular vesicles (EVs) are a source of non‐invasive biomarkers with potential for routine monitoring and to complement or replace invasive bone marrow biopsy. In this study, five proteins were significantly different from healthy controls and three associated with long‐term response on Daratumumab which may have ...
Kieran Brennan +5 more
wiley +1 more source
Real-world outcomes in patients with relapsed and refractory multiple myeloma with prior proteasome inhibitor and lenalidomide exposure: A single-center study in Sweden. [PDF]
Luong V +12 more
europepmc +1 more source
ABSTRACT Secondary plasma cell leukemia (sPCL) is a rare, aggressive manifestation of multiple myeloma (MM). We report a 75‐year‐old Japanese man with anemia as the chief complaint and IgG‐λ MM that rapidly progressed to sPCL. Whole genome sequencing using Canopy revealed a major clone with a monoallelic TP53 mutation.
Tomotaka Suzuki +4 more
wiley +1 more source
Correlation Between CD38<sup>+</sup> Cell Levels and Pulmonary Tuberculosis Complicated with Diabetes Mellitus: A Retrospective Analysis Based on Lymphocyte Subsets and Clinical Features. [PDF]
Wang Y, Mao W, Xu L, Xu W.
europepmc +1 more source
ABSTRACT Introduction Acute myeloid leukemia (AML) with plasmacytoid dendritic cell differentiation (pDC‐AML) is a newly described subtype of leukemia with features resembling blastic plasmacytoid dendritic cell neoplasm (BPDCN). Case Presentation Herein, we present a case of pDC‐AML in which bone marrow findings were best classified as AML, whereas ...
Benjamin J. Lee +5 more
wiley +1 more source
Propagation of monocyte exhaustion memory and underlying mechanisms. [PDF]
Wang J +4 more
europepmc +1 more source

