Results 211 to 220 of about 67,119 (304)

Ph‐Negative Acute Lymphoblastic Leukemia in the Older Adults: Biology, Therapeutic Strategies and Unmet Needs

European Journal of Haematology, Volume 117, Issue 1, Page 24-41, July 2026.
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Santino Caserta, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Marco Fiorillo, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Immunogenicity and safety of a third and subsequent COVID-19 vaccine doses in patients with plasma cell dyscrasias. [PDF]

Blood Adv
Bhella S, Agbayani G, Hueniken K, Vijenthira A, Wilkin AM, Sebag M, Wang P, Hicks LK, Hay AE, Hosseini-Moghaddam SM, Assouline S, Balitsky A, Fraser G, Mangel J, Owen C, Reiman A, Sehn L, Sutherland H, Arnold C, McCurdy A, Reece D, Leite T, McCarthy E, Cooper C, Crawley AM, Langlois MA, Buchan CA, Allan D, Aw A, Betschel S, Bolotin S, Brandwein J, Bredeson C, Brooks J, Cheung M, Chu M, Gupta V, Kekre N, Kumar D, Moltzan C, Prica A, Stakiw J, Wright A, Baetz T, Dudebout J.   +44 more
europepmc   +1 more source

Circulating CD38⁺ regulatory T cells are decreased in bone fracture non-union with chronic subclinical infection. [PDF]

Sci Rep
Fehrenbach P, Siverino C, Trenkwalder K, Erichsen S, Hackl S, Weisemann F, Muthukrishnan G, Riool M, Akdis CA, Garcia-Vallejo JJ, Zaat SAJ, de Jong EC, Moriarty TF.   +12 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Targeting of CD28 and CD38 as a potential novel therapeutic strategy for peripheral T-cell lymphomas. [PDF]

Sci Rep
Dupuy A, Pelletier L, Beldi-Ferchiou A, Poullot E, Tari G, Naudet J, Lemonnier F, Fataccioli V, Gupta B, Kim PS, Bisht K, Wang H, Van de Velde H, Gaulard P, Ortonne N.   +14 more
europepmc   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Predicting Positive Affect in Infancy. [PDF]

Dev Sci
Grossmann T, Miller H, Allison O.
europepmc   +1 more source

Stage‐Dependent Transcriptional Reprogramming of B‐Cell Receptor Signaling and Antigen Presentation During Bovine Leukemia Virus–Driven Lymphomagenesis

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Bovine leukemia virus (BLV), an oncogenic deltaretrovirus, establishes lifelong infection in cattle and induces enzootic bovine leukosis in a subset of animals following prolonged latency. Despite extensive evidence of immune dysregulation, stage‐specific transcriptional reprogramming of B cells, the primary viral reservoir remains ...
Mohammad Mehdi Akbarin, Zahra Farjami, Cecilia Rodríguez Murillo, Víctor David González‐Fernández, Gabriel Eduardo Acevedo‐Jiménez, Lucero de María Ávila‐De la Vega, Hugo Ramírez Álvarez   +6 more
wiley   +1 more source

Increased CD95⁺ or CD160⁺ double-negative T-cell subsets are associated with incomplete immune reconstitution in ART-treated people living with HIV. [PDF]

Front Immunol
Peng J, Li Y, Xi J, Xia Z, Luo P, Yang S, Lu L, Chen C, Cai R, Wang Q, Wei H.   +10 more
europepmc   +1 more source

Elucidating Immune Cell Mediated Causal Pathways Linking Blood Metabolites to Major Depressive Disorder: A Mediation Mendelian Randomization Analysis

Brain and Behavior, Volume 16, Issue 6, June 2026.
Our integrative Mendelian randomization framework revealed that specific circulating metabolites exert causal effects on major depressive disorder, partly through immune‐cell–mediated pathways. These findings highlight metabolite–immune interactions as potential mechanistic targets for MDD prevention and therapy.
Zhiwei Xu, Yining Zhou, Xuecheng Zhang, Xiaowen Chen, Yajing Li, Jintao Wang, Ting Chang, Zhen Yuan, Hongling Jia   +8 more
wiley   +1 more source