Results 171 to 180 of about 28,618 (205)

Salutary roles of CD39 in transplantation

Transplantation Reviews, 2007
Abstract Transplantation exposes vascularized grafts to several potential injuries, including ischemia-reperfusion injury and rejection. These processes are associated with, at least in part, extracellular nucleotide-triggered (type 2 purinergic receptor) inflammatory responses that if left unchecked might compromise the long-term function and ...
Karen M. Dwyer, Silvia Deaglio, Sandra Crikis, Wenda Gao, Keiichi Enjyoji, Terry B. Strom, Peter J. Cowan, Anthony J.F. d'Apice, Simon C. Robson   +8 more
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CD39 as a metabolic rheostat of immunoregulation

Cellular & Molecular Immunology
L. Zhang et al. proposed novel immunotherapeutic strategies to limit the progression of inflammatory bowel diseases by targeting the interplay between the membrane-bound CD39 molecule and cellular metabolism — specifically, by increasing regulatory T-cell function through the modulation of glucose metabolism and suppressing pathogenic proinflammatory ...
Barnaba, Vincenzo, Sozzani, Silvano
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Structure and function of ectoapyrase (CD39)

Drug Development Research, 1998
Although the presence of nucleotidase activities on the extracellular surface of cells has been known for many years, the enzymes responsible for these activities in animal cells have only recently been identified. Here, we describe how we cloned the gene for potato apyrase and, thus, found the way to identify CD39 as the animal cell ectoapyrase.
Ting-Fang Wang, Masahisa Handa, Guido Guidotti   +2 more
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Development of CD39 as a therapy for stroke

2022
The brain is detrimentally affected after stroke and cardiac arrest. The aim of this thesis was to demonstrate that the novel drug from our lab - αVCAM-CD39 will improve neurological outcome in mouse models of stroke and cardiac arrest. We found that post- αVCAM-CD39 treatment, there was significant protection in the brain, and we showed that our ...
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Preservation of cochlear function in Cd39 deficient mice

Hearing Research, 2009
Signalling actions of extracellular nucleotides via P2 receptors influence cellular function in most tissues. In the inner ear, P2 receptor signaling is involved in many processes including the regulation of hearing sensitivity and the cochlea's response to noise stress.
Srdjan M, Vlajkovic, Gary D, Housley, Peter R, Thorne, Rita, Gupta, Keiichi, Enjyoji, Peter J, Cowan, M, Charles Liberman, Simon C, Robson   +7 more
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CD39 downregulation in chronic intervillositis of unknown etiology

Virchows Archiv, 2019
Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion associated with infiltration of mononuclear inflammatory cells into the intervillous space, poor perinatal outcomes (intrauterine fetal demise or fetal growth restriction), and high rates of recurrence.
Yuichiro Sato, Kazunari Maekawa, Murasaki Aman, Atushi Yamashita, Yuki Kodama, Yohei Maki, Hiroshi Sameshima, Yujiro Asada   +7 more
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The skinny on CD39 in immunity and inflammation

Nature Medicine, 2002
The finding that CD39 on Langerhans cells modulates inflammation and immunity in the skin might lead to new strategies to alter immune responses to benefit patients and suggests a new in vitro technique for assessing the irritant potential of topical agents. ( pages 358–365 )
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Abstract 13: Suppression of Atherosclerosis by CD39

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
Atherosclerotic plaque rupture and thrombosis remains the leading cause of death in the United States. We investigated the role of CD39, a potent ecto-enzymatic regulator of platelet activation and leukocyte trafficking, in atherosclerosis. We generated mice deficient in CD39 on a hyperlipidemic, apoE -/-
Yogendra Kanthi, Matthew Hyman, Hui Liao, Amy Baek, Scott Visovatti, Nadia Sutton, Wakako Takabe, Chih-Wen Ni, Hanjoong Jo, David Pinsky   +9 more
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Vascular ATP Diphosphohydrolase (CD39/ATPDase)

1997
Circulatory homeostasis is usually maintained by quiescent endothelial cells that possess highly effective anticoagulant and platelet thromboregulatory mechanisms. Following injury, the vascular endothelium is considered to undergo a process of activation where cells are exposed to oxidative stress, lose intrinsic antithrombotic properties and become ...
Elzbieta Kaczmarek, Jonathan B. Siegel, Jean Sevigny, Katarzyna Koziak, Wayne W. Hancock, Adrien Beaudoin, Fritz H. Bach, Simon C. Robson   +7 more
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Novel Modulators of CD39 and CD73

CD39 and CD73 are crucial in purinergic signalling, converting triphosphate and diphosphate nucleotides such as ATP and ADP into AMP, which CD73 further degrades into adenosine. CD39 and CD73 dysregulation is linked to various diseases. In cancer, their upregulation is associated with immune suppression, while downregulation in autoimmune disorders ...
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