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Nature Reviews Immunology, 2020 The ATP–adenosine pathway functions as a key modulator of innate and adaptive immunity within the tumour microenvironment. Consequently, multiple clinical strategies are being explored to target this pathway for the treatment of cancer; in particular ...
Mark J. Smyth +2 more
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CD39 Regulation and Functions in T Cells [PDF]
International Journal of Molecular Sciences, 2021 CD39 is an enzyme which is responsible, together with CD73, for a cascade converting adenosine triphosphate into adenosine diphosphate and cyclic adenosine monophosphate, ultimately leading to the release of an immunosuppressive form of adenosine in the tumor microenvironment.
Vincenzo Barnaba, Eleonora Timperi
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Implications of CD39 in Immune-Related Diseases
International Immunopharmacology, 2020 Extracellular adenosine triphosphate (eATP) mediates pro-inflammatory responses by recruiting and activating inflammatory cells. CD39 can hydrolyze eATP into adenosine monophosphate (AMP), while CD73 can convert AMP into the immunosuppressive nucleoside adenosine (ADO).
Chunxia Li
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CD39 as a Caveolar-Associated Ectonucleotidase
Biochemical and Biophysical Research Communications, 1999CD39 is a human lymphoid cell activation antigen, (also referred to E-ATPDase or apyrase) that hydrolyzes extracellular ATP and ADP. Although it has been widely studied, its physiological role, however, still remains unclear. This ectonucleotidase generally is said to be evenly distributed in the membrane of the cells. However, we observed that in cell
A, Kittel +5 more
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Blood, 2013
In this issue of Blood , Hohmann et al describe a new antithrombotic strategy that involves delayed targeting of CD39 to activated platelets, which reduces thrombus size without increasing bleeding.[1][1] ![Figure][2] (A) Platelet thrombus formation occurs in a stepwise process.
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In this issue of Blood , Hohmann et al describe a new antithrombotic strategy that involves delayed targeting of CD39 to activated platelets, which reduces thrombus size without increasing bleeding.[1][1] ![Figure][2] (A) Platelet thrombus formation occurs in a stepwise process.
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Science Translational Medicine, 2012
Overexpression of CD39 in the lungs helps clear bacteria.
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Overexpression of CD39 in the lungs helps clear bacteria.
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CD39 And CD73: Biological Functions, Diseases and Therapy
Molecular BiomedicineAbstract Cluster of differentiation 39 (CD39) and CD73 are ectonucleotidases that play pivotal roles in purinergic signaling. CD39 catalyzes the hydrolysis of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) and subsequently to adenosine monophosphate (AMP), while CD73 further catalyzes the hydrolysis of AMP to adenosine ...
Yongsheng Li
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Abstract B3: CD39+ cancer cells mediate immunosuppression reverted by CD39-blocking antibodies.
Cancer Research, 2013Abstract The CD39 and CD73 ectonucleotidases hydrolyze extracellular ATP and ADP into immunosuppressive adenosine that binds adenosine receptor and inhibits T cell and NK cell responses. It has been demonstrated that CD39+ Tregs are increased in some human cancers and participate to immunosuppression.
Anne Regairaz +6 more
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Salutary roles of CD39 in transplantation
Transplantation Reviews, 2007Abstract Transplantation exposes vascularized grafts to several potential injuries, including ischemia-reperfusion injury and rejection. These processes are associated with, at least in part, extracellular nucleotide-triggered (type 2 purinergic receptor) inflammatory responses that if left unchecked might compromise the long-term function and ...
Karen M. Dwyer +8 more
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Structure and function of ectoapyrase (CD39)
Drug Development Research, 1998Although the presence of nucleotidase activities on the extracellular surface of cells has been known for many years, the enzymes responsible for these activities in animal cells have only recently been identified. Here, we describe how we cloned the gene for potato apyrase and, thus, found the way to identify CD39 as the animal cell ectoapyrase.
Ting-Fang Wang +2 more
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