Results 201 to 210 of about 31,390 (228)

Preservation of cochlear function in Cd39 deficient mice

Hearing Research, 2009
Signalling actions of extracellular nucleotides via P2 receptors influence cellular function in most tissues. In the inner ear, P2 receptor signaling is involved in many processes including the regulation of hearing sensitivity and the cochlea's response to noise stress.
Srdjan M, Vlajkovic, Gary D, Housley, Peter R, Thorne, Rita, Gupta, Keiichi, Enjyoji, Peter J, Cowan, M, Charles Liberman, Simon C, Robson   +7 more
openaire   +2 more sources

CD39 downregulation in chronic intervillositis of unknown etiology

Virchows Archiv, 2019
Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion associated with infiltration of mononuclear inflammatory cells into the intervillous space, poor perinatal outcomes (intrauterine fetal demise or fetal growth restriction), and high rates of recurrence.
Yuichiro Sato, Kazunari Maekawa, Murasaki Aman, Atushi Yamashita, Yuki Kodama, Yohei Maki, Hiroshi Sameshima, Yujiro Asada   +7 more
openaire   +2 more sources

The skinny on CD39 in immunity and inflammation

Nature Medicine, 2002
The finding that CD39 on Langerhans cells modulates inflammation and immunity in the skin might lead to new strategies to alter immune responses to benefit patients and suggests a new in vitro technique for assessing the irritant potential of topical agents. ( pages 358–365 )
openaire   +1 more source

Abstract 13: Suppression of Atherosclerosis by CD39

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
Atherosclerotic plaque rupture and thrombosis remains the leading cause of death in the United States. We investigated the role of CD39, a potent ecto-enzymatic regulator of platelet activation and leukocyte trafficking, in atherosclerosis. We generated mice deficient in CD39 on a hyperlipidemic, apoE -/-
Yogendra Kanthi, Matthew Hyman, Hui Liao, Amy Baek, Scott Visovatti, Nadia Sutton, Wakako Takabe, Chih-Wen Ni, Hanjoong Jo, David Pinsky   +9 more
openaire   +1 more source

Vascular ATP Diphosphohydrolase (CD39/ATPDase)

1997
Circulatory homeostasis is usually maintained by quiescent endothelial cells that possess highly effective anticoagulant and platelet thromboregulatory mechanisms. Following injury, the vascular endothelium is considered to undergo a process of activation where cells are exposed to oxidative stress, lose intrinsic antithrombotic properties and become ...
Elzbieta Kaczmarek, Jonathan B. Siegel, Jean Sevigny, Katarzyna Koziak, Wayne W. Hancock, Adrien Beaudoin, Fritz H. Bach, Simon C. Robson   +7 more
openaire   +1 more source

Novel Modulators of CD39 and CD73

CD39 and CD73 are crucial in purinergic signalling, converting triphosphate and diphosphate nucleotides such as ATP and ADP into AMP, which CD73 further degrades into adenosine. CD39 and CD73 dysregulation is linked to various diseases. In cancer, their upregulation is associated with immune suppression, while downregulation in autoimmune disorders ...
openaire   +1 more source

CD39-CD73-adenosine effects in Sézary syndrome

Blood, 2023
Sean Whittaker, Christine L. Jones
openaire   +2 more sources

A2AR limits IL-15-induced generation of CD39+ NK cells with high cytotoxicity

International Immunopharmacology, 2023
Jingjing Cong, Longxiang Tao, Lu Zong
exaly  

CD39

1997
A. Neil Barclay, Marion H. Brown, S.K. Alex Law, Andrew J. McKnight, Michael G. Tomlinson, P. Anton van der Merwe   +5 more
openaire   +1 more source

The CD39+ HBV surface protein-targeted CAR-T and personalized tumor-reactive CD8+ T cells exhibit potent anti-HCC activity

Molecular Therapy, 2021
Ting Liu, Jiaping Li, Bingfeng Liu
exaly