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What Else Can CD39 Tell Us? [PDF]
Frontiers in Immunology, 2017 As the rate-limiting enzyme in ATP/ADP–AMP–adenosine pathway, CD39 would be a novel checkpoint inhibitor target in preventing adenosine-triggered immune-suppressive effect.
Wang Ruoran, Zhao Hai
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CD39 as a Caveolar-Associated Ectonucleotidase
Biochemical and Biophysical Research Communications, 1999CD39 is a human lymphoid cell activation antigen, (also referred to E-ATPDase or apyrase) that hydrolyzes extracellular ATP and ADP. Although it has been widely studied, its physiological role, however, still remains unclear. This ectonucleotidase generally is said to be evenly distributed in the membrane of the cells. However, we observed that in cell
A, Kittel +5 more
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Genetically driven CD39 expression shapes human tumor‐infiltrating CD8+ T‐cell functions [PDF]
International Journal of Cancer, 2020 In this study, we investigated the role of CD39 on tumor-infiltrating CD8+ T lymphocytes (CD8+ TILs) in colorectal, head and neck and pancreatic cancers.
Ombretta Melaiu +2 more
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Blood, 2013
In this issue of Blood , Hohmann et al describe a new antithrombotic strategy that involves delayed targeting of CD39 to activated platelets, which reduces thrombus size without increasing bleeding.[1][1] ![Figure][2] (A) Platelet thrombus formation occurs in a stepwise process.
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In this issue of Blood , Hohmann et al describe a new antithrombotic strategy that involves delayed targeting of CD39 to activated platelets, which reduces thrombus size without increasing bleeding.[1][1] ![Figure][2] (A) Platelet thrombus formation occurs in a stepwise process.
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Science Translational Medicine, 2012
Overexpression of CD39 in the lungs helps clear bacteria.
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Overexpression of CD39 in the lungs helps clear bacteria.
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CD39 transforming cancer therapy by modulating tumor microenvironment [PDF]
Cancer LettersCD39 is a pivotal enzyme in cancer, regulating immune response and tumor progression via extracellular ATP and adenosine in the tumor microenvironment (TME).
Wenxue Ma, Qingqing Wang
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CD39 as a metabolic rheostat of immunoregulation
Cellular & Molecular ImmunologyL. Zhang et al. proposed novel immunotherapeutic strategies to limit the progression of inflammatory bowel diseases by targeting the interplay between the membrane-bound CD39 molecule and cellular metabolism — specifically, by increasing regulatory T-cell function through the modulation of glucose metabolism and suppressing pathogenic proinflammatory ...
Barnaba, Vincenzo, Sozzani, Silvano
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Abstract B3: CD39+ cancer cells mediate immunosuppression reverted by CD39-blocking antibodies.
Cancer Research, 2013Abstract The CD39 and CD73 ectonucleotidases hydrolyze extracellular ATP and ADP into immunosuppressive adenosine that binds adenosine receptor and inhibits T cell and NK cell responses. It has been demonstrated that CD39+ Tregs are increased in some human cancers and participate to immunosuppression.
Anne Regairaz +6 more
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Structure and function of ectoapyrase (CD39)
Drug Development Research, 1998Although the presence of nucleotidase activities on the extracellular surface of cells has been known for many years, the enzymes responsible for these activities in animal cells have only recently been identified. Here, we describe how we cloned the gene for potato apyrase and, thus, found the way to identify CD39 as the animal cell ectoapyrase.
Ting-Fang Wang +2 more
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Development of CD39 as a therapy for stroke
2022The brain is detrimentally affected after stroke and cardiac arrest. The aim of this thesis was to demonstrate that the novel drug from our lab - αVCAM-CD39 will improve neurological outcome in mouse models of stroke and cardiac arrest. We found that post- αVCAM-CD39 treatment, there was significant protection in the brain, and we showed that our ...
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