Results 201 to 210 of about 37,805 (220)

CD39 as a Caveolar-Associated Ectonucleotidase

Biochemical and Biophysical Research Communications, 1999
CD39 is a human lymphoid cell activation antigen, (also referred to E-ATPDase or apyrase) that hydrolyzes extracellular ATP and ADP. Although it has been widely studied, its physiological role, however, still remains unclear. This ectonucleotidase generally is said to be evenly distributed in the membrane of the cells. However, we observed that in cell
A, Kittel, E, Kaczmarek, J, Sevigny, K, Lengyel, E, Csizmadia, S C, Robson   +5 more
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Abstract B3: CD39+ cancer cells mediate immunosuppression reverted by CD39-blocking antibodies.

Cancer Research, 2013
Abstract The CD39 and CD73 ectonucleotidases hydrolyze extracellular ATP and ADP into immunosuppressive adenosine that binds adenosine receptor and inhibits T cell and NK cell responses. It has been demonstrated that CD39+ Tregs are increased in some human cancers and participate to immunosuppression.
Anne Regairaz, Caroline Laheurte, Nathalie Bonnefoy, Jean-Francois Eliaou, Gilles Alberici, Armand Bensussan, Jeremy Bastid   +6 more
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CD39 target practice

Blood, 2013
In this issue of Blood , Hohmann et al describe a new antithrombotic strategy that involves delayed targeting of CD39 to activated platelets, which reduces thrombus size without increasing bleeding.[1][1] ![Figure][2] (A) Platelet thrombus formation occurs in a stepwise process.
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CD39 to the Rescue

Science Translational Medicine, 2012
Overexpression of CD39 in the lungs helps clear bacteria.
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CD39 downregulation in chronic intervillositis of unknown etiology

Virchows Archiv, 2019
Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion associated with infiltration of mononuclear inflammatory cells into the intervillous space, poor perinatal outcomes (intrauterine fetal demise or fetal growth restriction), and high rates of recurrence.
Yuichiro Sato, Kazunari Maekawa, Murasaki Aman, Atushi Yamashita, Yuki Kodama, Yohei Maki, Hiroshi Sameshima, Yujiro Asada   +7 more
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Salutary roles of CD39 in transplantation

Transplantation Reviews, 2007
Abstract Transplantation exposes vascularized grafts to several potential injuries, including ischemia-reperfusion injury and rejection. These processes are associated with, at least in part, extracellular nucleotide-triggered (type 2 purinergic receptor) inflammatory responses that if left unchecked might compromise the long-term function and ...
Karen M. Dwyer, Silvia Deaglio, Sandra Crikis, Wenda Gao, Keiichi Enjyoji, Terry B. Strom, Peter J. Cowan, Anthony J.F. d'Apice, Simon C. Robson   +8 more
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Vascular ATP Diphosphohydrolase (CD39/ATPDase)

1997
Circulatory homeostasis is usually maintained by quiescent endothelial cells that possess highly effective anticoagulant and platelet thromboregulatory mechanisms. Following injury, the vascular endothelium is considered to undergo a process of activation where cells are exposed to oxidative stress, lose intrinsic antithrombotic properties and become ...
Elzbieta Kaczmarek, Jonathan B. Siegel, Jean Sevigny, Katarzyna Koziak, Wayne W. Hancock, Adrien Beaudoin, Fritz H. Bach, Simon C. Robson   +7 more
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Preservation of cochlear function in Cd39 deficient mice

Hearing Research, 2009
Signalling actions of extracellular nucleotides via P2 receptors influence cellular function in most tissues. In the inner ear, P2 receptor signaling is involved in many processes including the regulation of hearing sensitivity and the cochlea's response to noise stress.
Srdjan M, Vlajkovic, Gary D, Housley, Peter R, Thorne, Rita, Gupta, Keiichi, Enjyoji, Peter J, Cowan, M, Charles Liberman, Simon C, Robson   +7 more
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Structure and function of ectoapyrase (CD39)

Drug Development Research, 1998
Although the presence of nucleotidase activities on the extracellular surface of cells has been known for many years, the enzymes responsible for these activities in animal cells have only recently been identified. Here, we describe how we cloned the gene for potato apyrase and, thus, found the way to identify CD39 as the animal cell ectoapyrase.
Ting-Fang Wang, Masahisa Handa, Guido Guidotti   +2 more
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CD39-CD73-adenosine effects in Sézary syndrome

Blood, 2023
Sean Whittaker, Christine L. Jones
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