Results 1 to 10 of about 499,016 (99)

Adaptive-like CAR-iPSC-CD4⁺ T cells outperform CD8⁺ counterparts in sustained ALL control [PDF]

Inflammation and Regeneration
Background Induced pluripotent stem cell (iPSC)–derived T cells offer a renewable source for off-the-shelf immunotherapy. With the advent of the artificial thymic organoid (ATO) method, the in vitro differentiation of CD4+ T cells from iPSCs has also ...
Qingyi Guo, Chaoqi Zhang, Bo Wang, Shoichi Iriguchi, Akihiro Ishikawa, Atsutaka Minagawa, Tomoko Ishii, Yohei Kawai, Shin Kaneko   +8 more
doaj   +2 more sources

Tumor-Specific CD4+ T Cells Restrain Established Metastatic Melanoma by Developing Into Cytotoxic CD4– T Cells

Frontiers in Immunology, 2022
Cytotoxic CD8+ T cells are the main focus of efforts to understand anti-tumor immunity and immunotherapy. The adoptive transfer of tumor-reactive cytotoxic CD8+ T lymphocytes expanded and differentiated in vitro has long been considered the primary ...
Qiao Liu, Lisha Wang, Huayu Lin, Zhiming Wang, Jialin Wu, Junyi Guo, Shuqiong Wen, Ling Ran, Zhengliang Yue, Xingxing Su, Qing Wu, Jianfang Tang, Zhirong Li, Li Hu, Lifan Xu, Lilin Ye, Qizhao Huang, Qizhao Huang   +17 more
doaj   +1 more source

Human CD4 memory T cells can become CD4+IL-9+ T cells. [PDF]

PLoS ONE, 2010
IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-beta directs mouse CD4(+)CD25(-)CD62L(+) T cells to commit to inflammatory IL-9 producing CD4(+) T cells.Here we show that human ...
Prabhakar Putheti, Amit Awasthi, Joyce Popoola, Wenda Gao, Terry B Strom   +4 more
doaj   +1 more source

Circulating activated immune cells as a potential blood biomarkers of non-small cell lung cancer occurrence and progression

BMC Pulmonary Medicine, 2021
Background Treatment for non-small cell lung cancer (NSCLC) has greatly improved in recent years. However, noninvasive early screening for carcinogenesis and progression unclear.
Yingyi Wang, Na Zhou, Rui Zhu, Xiaoyuan Li, Zhao Sun, Yang Gao, Wei Liu, Changting Meng, Yuping Ge, Chunmei Bai, Taisheng Li, Hongsheng Liu   +11 more
doaj   +1 more source

Regulation and gene expression profiling of NKG2D positive human cytomegalovirus-primed CD4+ T-cells. [PDF]

PLoS ONE, 2012
NKG2D is a stimulatory receptor expressed by natural killer (NK) cells, CD8(+) T-cells, and γδ T-cells. NKG2D expression is normally absent from CD4(+) T-cells, however recently a subset of NKG2D(+) CD4(+) T-cells has been found, which is specific for ...
Helle Jensen, Lasse Folkersen, Søren Skov   +2 more
doaj   +1 more source

Failure of CD4 T-cells to respond to liver-derived antigen and to provide help to CD8 T-cells. [PDF]

PLoS ONE, 2011
CD4 T-cell help is required for the induction of efficient CD8 T-cells responses and the generation of memory cells. Lack of CD4 T-cell help may contribute to an exhausted CD8 phenotype and viral persistence.
Katja Derkow, Anja Müller, Ira Eickmeier, Daniel Seidel, Marcos Vicinius Rust Moreira, Nils Kruse, Katja Klugewitz, Justine Mintern, Bertram Wiedenmann, Eckart Schott   +9 more
doaj   +1 more source

CD4(+)CD62L(+) central memory T cells can be converted to Foxp3(+) T cells. [PDF]

PLoS ONE, 2013
The peripheral Foxp3(+) Treg pool consists of naturally arising Treg (nTreg) and adaptive Treg cells (iTreg). It is well known that naive CD4(+) T cells can be readily converted to Foxp3(+) iTreg in vitro, and memory CD4(+) T cells are resistant to ...
Xiaolong Zhang, Xian Chang Li, Xiang Xiao, Rui Sun, Zhigang Tian, Haiming Wei   +5 more
doaj   +1 more source

Metabolic features of naïve and memory CD4⁺T cells in quiescence and during proliferation

Acta Biomedica Scientifica, 2022
Background. Memory CD4+ T cells proliferation is the basis for accelerated secondary immune response. The characteristics of memory CD4+ T cells providing their faster division compared to naive CD4+ T lymphocytes are poorly understood.
V. V. Vlasova, E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel, K. V. Shmagel   +4 more
doaj   +1 more source

T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections

Cell Reports, 2023
Summary: CD4+ T cells are key components of the immune response during lung infections and can mediate protection against tuberculosis (TB) or influenza. However, CD4+ T cells can also promote lung pathology during these infections, making it unclear how
Igor Santiago-Carvalho, Gislane Almeida-Santos, Bruna Gois Macedo, Caio Cesar Barbosa-Bomfim, Fabricio Moreira Almeida, Marcos Vinícios Pinheiro Cione, Trupti Vardam-Kaur, Mia Masuda, Sarah Van Dijk, Bruno Marcel Melo, Rogério Silva do Nascimento, Rebeka da Conceição Souza, Alba Lucínia Peixoto-Rangel, Robson Coutinho-Silva, Mario Hiroyuki Hirata, José Carlos Alves-Filho, José Maria Álvarez, Elena Lassounskaia, Henrique Borges da Silva, Maria Regina D’Império-Lima   +19 more
doaj   +1 more source

Memory T follicular helper CD4 T cells

Frontiers in Immunology, 2015
T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity.
J. Scott eHale, Rafi eAhmed
doaj   +1 more source