Results 11 to 20 of about 499,185 (263)
Current Opinion in Immunology, 2001 There is now compelling evidence that CD4(+) T cells that specialize in the suppression of immune responses play a key role in the control of immune pathology. Recently, there have been a number of reports that have provided information on the generation of CD4(+) regulatory T cells in the thymus and in the periphery.
Read, S, Powrie, F
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Journal for ImmunoTherapy of Cancer, 2019 Background Transient CD4+ T cell depletion led to the proliferation of tumor-specific CD8+ T cells in the draining lymph node and increased infiltration of PD-1+CD8+ T cells into the tumor, which resulted in strong anti-tumor effects in tumor-bearing ...
Kohei Shitara +20 more
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The role of CD4+ T cells in tumor and chronic viral immune responses
MedComm, 2023 Immunotherapies are mainly aimed to promote a CD8+ T cell response rather than a CD4+ T cell response as cytotoxic T lymphocytes (CTLs) can directly kill target cells.
Luoyingzi Xie +6 more
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The Journal of Experimental Medicine, 2005 CD4+ T cells continuously monitor antigen levels in their environment and adjust their expansion accordingly, as shown on [page 1555][1]. Obst and colleagues demonstrate that when antigen runs out, CD4+ T cell proliferation stops dead in its tracks.
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CD4+ primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10, suppressing CD4 and CD8 T cells. [PDF]
PLoS ONE, 2014 Adaptive T cell responses are critical for controlling HCV infection. While there is clinical evidence of a relevant role for regulatory T cells in chronic HCV-infected patients, based on their increased number and function; mechanisms underlying such a ...
Cecilia Fernandez-Ponce +3 more
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Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies. [PDF]
PLoS Pathogens, 2009 The progressive decline of CD4(+) T cells is a hallmark of disease progression in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection.
Takeo Kuwata +9 more
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Generation and Immune Regulation of CD4+CD25−Foxp3+ T Cells in Chronic Obstructive Pulmonary Disease
Frontiers in Immunology, 2019 The imbalance of CD4+Foxp3+ T cell subsets is reportedly involved in abnormal inflammatory immune responses in patients with chronic obstructive pulmonary disease (COPD).
Jiang-Hua Wu +8 more
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T Regulatory Cells Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia [PDF]
Iranian Journal of Immunology, 2020 Background: Drugs used in cancer treatment specifically kill T regulatory cells. Objective: To determine different phenotypes of T regulatory cells during the maintenance phase chemotherapy for pediatric acute lymphoblastic leukemia (ALL).
Marina Nayeli Medina-Rosales +2 more
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Protective effector memory CD4 T cells depend on ICOS for survival. [PDF]
PLoS ONE, 2011 Memory CD4 T cells play a vital role in protection against re-infection by pathogens as diverse as helminthes or influenza viruses. Inducible costimulator (ICOS) is highly expressed on memory CD4 T cells and has been shown to augment proliferation and ...
Tamson V Moore +8 more
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CD4 T Cell-Dependent CD8 T Cell Maturation [PDF]
The Journal of Immunology, 2004 Abstract We have investigated the contribution of CD4 T cells to the optimal priming of functionally robust memory CD8 T cell subsets. Intranasal infection of CD4 T cell-deficient (CD4−/−) mice with lymphocytic choriomeningitis virus resulted in the elaboration of virus-specific CD8 T cell responses that cleared the infection.
Aaruni, Khanolkar +2 more
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