Results 21 to 30 of about 499,185 (263)
Unbalanced Neonatal CD4+ T-Cell Immunity [PDF]
Frontiers in Immunology, 2014 In comparison to adults, newborns display a heightened susceptibility to pathogens and a propensity to develop allergic diseases. Particular properties of the neonatal immune system can account for this sensitivity. Indeed, a defect in developing protective Th1-type responses and a skewing toward Th2 immunity characterize today the neonatal T-cell ...
Debock, Isabelle, Flamand, Véronique
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Frontiers in Immunology, 2016 During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells.
Shintaro eHojyo +11 more
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Journal of Neuroinflammation, 2020 Background After peripheral nerve transection, facial motoneuron (FMN) survival depends on an intact CD4+ T cell population and a central source of interleukin-10 (IL-10). However, it has not been determined previously whether CD4+ T cells participate in
Elizabeth M. Runge +5 more
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STAT5 and CD4+ T Cell Immunity [PDF]
F1000Research, 2017 STAT5 plays a critical role in the development and function of many cell types. Here, we review the role of STAT5 in the development of T lymphocytes in the thymus and its subsequent role in the differentiation of distinct CD4+helper and regulatory T-cell subsets.
Owen, David L., Farrar, Michael A.
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Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection. [PDF]
PLoS Pathogens, 2018 The concerns raised from adenovirus 5 (Ad5)-based HIV vaccine clinical trials, where excess HIV infections were observed in some vaccine recipients, have highlighted the importance of understanding host responses to vaccine vectors and the HIV ...
Sarah Auclair +16 more
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CD4+T Cells: Differentiation and Functions [PDF]
Clinical and Developmental Immunology, 2012 CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper 1 and T-helper 2, other subsets have been identified,
Rishi Vishal Luckheeram +3 more
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In vitro induction of regulatory CD4+CD8α+ T cells by TGF-β, IL-7 and IFN-γ. [PDF]
PLoS ONE, 2013 In vitro CD4(+) T cell differentiation systems have made important contributions to understanding the mechanisms underlying the differentiation of naive CD4(+) T cells into effector cells with distinct biological functions.
Luc Van Kaer +4 more
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The type of responder T-cell has a significant impact in a human in vitro suppression assay. [PDF]
PLoS ONE, 2010 In type 1 diabetes (T1D), a prototypic autoimmune disease, effector T cells destroy beta cells. Normally, CD4(+)CD25(+high), or natural regulatory T cells (Tregs), counter this assault.
Srikanta Jana +7 more
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Cell Reports, 2021 Summary: CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-γ. Whether CD4 T cells act as “helper” cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is unknown.
Yu-Jung Lu +5 more
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Alteration of CD4CD25Foxp3 T cell level in Kawasaki disease [PDF]
Korean Journal of Pediatrics, 2011 PurposeExaggerated pro-inflammatory reactions during the acute phase of Kawasaki disease (KD) suggest the role of immune dysregulation in the pathogenesis of KD.
Su Ye Sohn +7 more
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