The multiverse of CD46 and oncologic interactions [PDF]
The Journal of Clinical InvestigationInitially identified as a regulator of complement activation on host cells, the known roles of CD46 (membrane cofactor protein [MCP]) have expanded. We now know that this ancient molecule is expressed on almost all nucleated cells as a family of four ...
M. Kathryn Liszewski, John P. Atkinson
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CD46 Null Packaging Cell Line Improves Measles Lentiviral Vector Production and Gene Delivery to Hematopoietic Stem and Progenitor Cells [PDF]
Molecular Therapy: Methods & Clinical Development, 2019 Lentiviral vectors (LVs) pseudotyped with the measles virus hemagglutinin (H) and fusion (F) glycoproteins have been reported to more efficiently transduce hematopoietic stem and progenitor cells (HSPCs) compared with vesicular stomatitis virus ...
Stosh Ozog +7 more
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Identification of a new CD46 gene mutation site in a family with atypical hemolytic uremic syndrome [PDF]
BMC NephrologyBackground Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy resulting from the dysregulation of the alternative complement pathway.
Benjin Hu +6 more
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Primary Cells from a CD46-Edited Bovine Heifer Have Reduced BVDV Susceptibility Despite Viral Adaptation to Heparan Sulfate [PDF]
VirusesA precision genome edit in the bovine CD46 gene (A82LPTFS87) dramatically reduced bovine viral diarrhea virus (BVDV) susceptibility in a cloned heifer. However, pathogen evolution threatens the long-term efficacy of such interventions.
Alexandria C. Krueger +4 more
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Complement gene expression profiles are altered in the AD frontal cortex [PDF]
Alzheimers DementAbstract Background Complement contributes significantly to pathophysiology in many neurodegenerative diseases (NDDs) including Alzheimer's Disease (AD); yet, the source of complement in the brain is poorly understood. Even multiple small changes to individual complement components can compound into significant dysregulation of the whole system ...
Bright M, Nguyen V, Morgan B, Zelek W.
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CD46 is a cellular receptor for species D human adenovirus [PDF]
mBioHuman adenovirus species D (HAdV-D) contains two-thirds of all known HAdV types (116 in total) and is important as a vector in clinical applications. However, the broad tropism exhibited by several HAdV-D types poses challenges for their use as targeted ...
Katarina Danskog +6 more
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CD46 Is a Protein Receptor for Human Adenovirus Type 64 [PDF]
VirusesCertain species D human adenoviruses (HAdV-D19, -D37, and -D64) are causative agents of epidemic keratoconjunctivitis. HAdV-D37 has previously been shown to bind CD46 (membrane cofactor protein) and sialic acid as adhesion receptors.
Eugene Y. Wu +8 more
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CD46 Gene Editing Confers Ex Vivo BVDV Resistance in Fibroblasts from Cloned Angus Calves [PDF]
VirusesA previous study demonstrated that a 19-nucleotide edit, encoding a six amino acid substitution in the bovine CD46 gene, dramatically reduced bovine viral diarrhea virus (BVDV) susceptibility in a cloned Gir (Bos indicus) heifer.
Aspen M. Workman +2 more
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Association Between Promoter Polymorphisms in CD46 and CD59 in Kidney Donors and Transplant Outcome
Frontiers in Immunology, 2018 Complement regulating proteins, including CD46, CD55, and CD59, protect cells against self-damage. Because of their expression on the donor endothelium, they are hypothesized to be involved in accommodation.
Laura A. Michielsen +4 more
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CD46 TREM1 regulates the autophagy marker LC3B ATG5 in oral squamous cell carcinoma [PDF]
Frontiers in OncologyObjectiveThis study aims to explore the regulatory effect of abnormal expression of CD46 and TREM1 on LC3B and ATG5 and to provide new targets for the molecular mechanism and treatment of OSCC.
Xiaodan Liu +8 more
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