Results 11 to 20 of about 17,628 (245)
Calcitriol modulates the CD46 pathway in T cells. [PDF]
PLoS ONE, 2012 The complement regulator CD46 is a costimulatory molecule for human T cells that induces a regulatory Tr1 phenotype, characterized by large amounts of IL-10 secretion.
Karoline Kickler +4 more
doaj +11 more sources
Structure of Bovine CD46 Ectodomain
Viruses, 2023 CD46, or membrane cofactor protein, is a type-one transmembrane protein from the complement regulatory protein family. Alongside its role in complement activation, CD46 is involved in many other processes, from T-cell activation to reproduction.
Hazel Aitkenhead +2 more
doaj +3 more sources
CD46 Genetic Variability and HIV-1 Infection Susceptibility [PDF]
Cells, 2021 CD46 is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. CD46 genetic variants are associated with susceptibility to several infectious and autoimmune diseases.
Carmen Serrano-Rísquez +12 more
doaj +7 more sources
Complement regulator CD46: genetic variants and disease associations [PDF]
Human Genomics, 2015 Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement. This type-I membrane glycoprotein serves as a cofactor for the serine protease factor I to mediate inactivation of C3b and C4b deposited on host cells. More than 60 disease-associated mutations in MCP have
Liszewski, M. Kathryn, Atkinson, John P
openaire +6 more sources
A novel role for CD46 in wound repair [PDF]
Frontiers in Immunology, 2011 The intestinal epithelium not only provides a vital physical barrier between the host and environment but is also required for uptake of nutrients and the induction of tolerance against commensals.
John eCardone +2 more
doaj +3 more sources
Frontiers in Medicine, 2020 Atypical hemolytic uremic syndrome (aHUS) is an ultra-rare disease characterized by microangiopathic hemolysis, thrombocytopenia, and renal impairment and is associated with dysregulation of the alternative complement pathway on the microvascular ...
Rossella Piras +12 more
doaj +2 more sources
Atypical Hemolytic Uremic Syndrome Triggered by COVID-19 Infection in a Pediatric Patient With CD46 Mutation. [PDF]
Clin Case RepLorestani P, Maleki Dana P, Tohidi MR.
europepmc +3 more sources
Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies [PDF]
, 2012 Lentiviral vectors (LVs) are potent gene transfer vehicles frequently applied in research and recently also in clinical trials. Retargeting LV entry to cell types of interest is a key issue to improve gene transfer safety and efficacy.
Abel, Tobias +5 more
core +10 more sources
Inhibition of cd46 receptor by rnai enhances cell resistance to bvdv infection [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020 This study aimed to investigate the inhibition effect of CD46 on the replication of bovine viral diarrhea viruses (BVDV). BVDV causes bovine viral diarrheal mucosal disease, and prevention of BVDV infection is very important for livestock production ...
Ruirui HU +7 more
doaj +1 more source