CD46 and oncologic interactions: Friendly fire against cancer [PDF]
Antibodies, 2020 One of the most challenging aspects of cancer therapeutics is target selection. Recently, CD46 (membrane cofactor protein; MCP) has emerged as a key player in both malignant transformation as well as in cancer treatments.
Atkinson, John P +2 more
core +5 more sources
CD46 protects the bladder cancer cells from cetuximab-mediated cytotoxicity
Scientific Reports, 2022 Epidermal growth factor receptor (EGFR) is an effective target for those patients with metastatic colorectal cancers that retain the wild-type RAS gene. However, its efficacy in many cancers, including bladder cancer, is unclear.
Manh-Hung Do +5 more
doaj +2 more sources
Real Time Analysis of Bovine Viral Diarrhea Virus (BVDV) Infection and Its Dependence on Bovine CD46
Viruses, 2020 Virus attachment and entry is a complex interplay of viral and cellular interaction partners. Employing bovine viral diarrhea virus (BVDV) encoding an mCherry-E2 fusion protein (BVDVE2-mCherry), being the first genetically labelled member of the family ...
Christiane Riedel +5 more
doaj +2 more sources
CD46 Is a Protein Receptor for Human Adenovirus Type 64 [PDF]
VirusesCertain species D human adenoviruses (HAdV-D19, -D37, and -D64) are causative agents of epidemic keratoconjunctivitis. HAdV-D37 has previously been shown to bind CD46 (membrane cofactor protein) and sialic acid as adhesion receptors.
Eugene Y. Wu +8 more
doaj +2 more sources
Primary Cells from a CD46-Edited Bovine Heifer Have Reduced BVDV Susceptibility Despite Viral Adaptation to Heparan Sulfate [PDF]
VirusesA precision genome edit in the bovine CD46 gene (A82LPTFS87) dramatically reduced bovine viral diarrhea virus (BVDV) susceptibility in a cloned heifer. However, pathogen evolution threatens the long-term efficacy of such interventions.
Alexandria C. Krueger +4 more
doaj +2 more sources
Viral Traits and Cellular Knock-Out Genotype Affect Dependence of BVDV on Bovine CD46
Pathogens, 2021 The role of bovine CD46 in the host cell entry of BVDV has been established for more than a decade. By generating novel MDBK CD46 knock-out clones, we confirm previously reported data on the CD46 motives important for BVDV binding and the importance of ...
Hann-Wei Chen +6 more
doaj +2 more sources
PLoS Pathogens, 2021 The frequent overexpression of CD46 in malignant tumors has provided a basis to use vaccine-lineage measles virus (MeV) as an oncolytic virotherapy platform.
Miguel Ángel Muñoz-Alía +6 more
doaj +2 more sources
Viruses, 2020 Bovine viral diarrhea virus (BVDV) entry into a host cell is mediated by the interaction of the viral glycoprotein E2 with the cellular transmembrane CD46 receptor.
Kevin P. Szillat +4 more
doaj +2 more sources
Atypical Hemolytic Uremic Syndrome Triggered by COVID-19 Infection in a Pediatric Patient With CD46 Mutation. [PDF]
Clin Case RepABSTRACT Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy (TMA) that is considered life‐threatening and caused by dysregulation of the complement system. Here, we report a previously healthy 8‐year‐old boy who presented with features of aHUS 1 week after viral symptoms during the COVID‐19 pandemic.
Lorestani P, Maleki Dana P, Tohidi MR.
europepmc +2 more sources
Absence of spermatozoal CD46 protein expression and associated rapid acrosome reaction rate in striped field mice (Apodemus agrarius) [PDF]
Reproductive Biology and Endocrinology, 2009 Background In rodents, the cell surface complement regulatory protein CD46 is expressed solely on the spermatozoal acrosome membrane. Ablation of the CD46 gene is associated with a faster acrosome reaction.
A Bashirullah +44 more
core +5 more sources