Results 21 to 30 of about 17,628 (245)

CD46 splice variant enhances translation of specific mRNAs linked to an aggressive tumor cell phenotype in bladder cancer

Molecular Therapy: Nucleic Acids, 2021
CD46 is well known to be involved in diverse biological processes. Although several splice variants of CD46 have been identified, little is known about the contribution of alternative splicing to its tumorigenic functions.
Jin Zeng, Hua Xu, Chunhua Huang, Yi Sun, Haibing Xiao, Gan Yu, Hui Zhou, Yangjun Zhang, Weimin Yao, Wei Xiao, Junhui Hu, Lily Wu, Jinchun Xing, Tao Wang, Zhiqiang Chen, Zhangqun Ye, Ke Chen   +16 more
doaj   +1 more source

CD46 and Oncologic Interactions: Friendly Fire against Cancer

Antibodies, 2020
One of the most challenging aspects of cancer therapeutics is target selection. Recently, CD46 (membrane cofactor protein; MCP) has emerged as a key player in both malignant transformation as well as in cancer treatments.
Michelle Elvington, M. Kathryn Liszewski, John P. Atkinson   +2 more
doaj   +1 more source

Morbillivirus Downregulation of CD46 [PDF]

Journal of Virology, 1998
ABSTRACTThere is evidence that CD46 (membrane cofactor protein) is a cellular receptor for vaccine and laboratory-passaged strains of measles virus (MV). Following infection with these MV strains, CD46 is downregulated from the cell surface, and consequent complement-mediated lysis has been shown to occur upon infection of a human monocytic cell line ...
S E, Galbraith, A, Tiwari, M D, Baron, B T, Lund, T, Barrett, S L, Cosby   +5 more
openaire   +2 more sources

Role of CD46 in Measles Virus Infection in CD46 Transgenic Mice [PDF]

Virology, 1998
The susceptibility of CD46 (human membrane cofactor protein) transgenic mice to measles virus (MV) infection was investigated. Cell cultures (lung and kidney) established from transgenic and control mice showed that although both could be infected only those from the CD46+ mice gave fusion. A complete round of replication with the release of infectious
Blixenkrone-Møller, M., Bernard, A., Bencsik, A., Sixt, N., Diamond, L. E., Logan, J. S., Wild, T. F.   +6 more
openaire   +2 more sources

Infection of polarized bovine respiratory epithelial cells by bovine viral diarrhea virus (BVDV)

Virulence, 2021
Bovine viral diarrhea virus (BVDV) is affecting cattle populations all over the world causing acute disease, immunosuppressive effects, respiratory diseases, gastrointestinal, and reproductive failure in cattle.
Ang Su, Yuguang Fu, Jochen Meens, Wei Yang, Fandan Meng, Georg Herrler, Paul Becher   +6 more
doaj   +1 more source

Real Time Analysis of Bovine Viral Diarrhea Virus (BVDV) Infection and Its Dependence on Bovine CD46

Viruses, 2020
Virus attachment and entry is a complex interplay of viral and cellular interaction partners. Employing bovine viral diarrhea virus (BVDV) encoding an mCherry-E2 fusion protein (BVDVE2-mCherry), being the first genetically labelled member of the family ...
Christiane Riedel, Hann-Wei Chen, Ursula Reichart, Benjamin Lamp, Vibor Laketa, Till Rümenapf   +5 more
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Advances in the design and development of oncolytic measles viruses. [PDF]

, 2015
A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian, Raffel, Corey, Studebaker, Adam W   +2 more
core   +1 more source

Function of complement regulatory proteins in immunity of reproduction: a review

Czech Journal of Animal Science, 2005
Humoral immunity has an important role during the maturation and development of the functional properties of spermatozoa. Spermatozoa may be exposed to antisperm antibodies in semen and in cervical, ovarian follicular and fallopian fluid.
J. Valentovičová, M. Simon, J. Antalíková   +2 more
doaj   +1 more source

Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens. [PDF]

PLoS Pathogens, 2010
The human membrane cofactor protein (MCP, CD46) is a central component of the innate immune system. CD46 protects autologous cells from complement attack by binding to complement proteins C3b and C4b and serving as a cofactor for their cleavage.
B David Persson, Nikolaus B Schmitz, César Santiago, Georg Zocher, Mykol Larvie, Ulrike Scheu, José M Casasnovas, Thilo Stehle   +7 more
doaj   +1 more source