Results 21 to 30 of about 18,453 (236)

Vitamin D/CD46 Crosstalk in Human T Cells in Multiple Sclerosis

Frontiers in Immunology, 2020
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), in which T-cell migration into the CNS is key for pathogenesis. Patients with MS exhibit impaired regulatory T cell populations, and both Foxp3+ Tregs and type
Justin Killick, Justin Killick, Joanne Hay, Joanne Hay, Elena Morandi, Sonja Vermeren, Saniya Kari, Thibault Angles, Anna Williams, Anna Williams, Jan Damoiseaux, Anne L. Astier, Anne L. Astier, Anne L. Astier   +13 more
doaj   +2 more sources

Measles Virus Recognizes Its Receptor, CD46, via Two Distinct Binding Domains within SCR1-2 [PDF]

, 1997
Measles virus (MV) enters cells by attachment of the viral hemagglutinin to the major cell surface receptor CD46 (membrane cofactor protein). CD46 is a transmembrane glycoprotein whose ectodomain is largely composed of four conserved modules called short
Alvarez, Jose, Atkinson, John P., Eto, Danelle S., Gairin, Jean Edouard, Liszewski, M.Kathryn, Manchester, Marianne, Oldstone, Michael B.A., Patterson, John B.   +7 more
core   +2 more sources

A Novel Role for CD46 in Wound Repair [PDF]

Frontiers in Immunology, 2011
The intestinal epithelium not only provides a vital physical barrier between the host and environment but is also required for uptake of nutrients and the induction of tolerance against commensals.
Al-Shouli, Samia, Cardone, John, Kemper, Claudia   +2 more
core   +5 more sources

CD46 knock-out using CRISPR/Cas9 editing of hTERT immortalized human cells modulates complement activation.

PLoS ONE, 2019
The kidney is especially sensitive to diseases associated with overactivation of the complement system. While most of these diseases affect kidney glomeruli and the microvasculature, there is also evidence for tubulointerstitial deposition of complement ...
Matthias Wieser, Teresa Francisci, Daniel Lackner, Tilmann Buerckstuemmer, Kamilla Wasner, Wolf Eilenberg, Anton Stift, Markus Wahrmann, Georg A Böhmig, Johannes Grillari, Regina Grillari-Voglauer   +10 more
doaj   +2 more sources

Structure of the Extracellular Portion of CD46 Provides Insights into Its Interactions with Complement Proteins and Pathogens [PDF]

PLoS Pathogens, 2010
The human membrane cofactor protein (MCP, CD46) is a central component of the innate immune system. CD46 protects autologous cells from complement attack by binding to complement proteins C3b and C4b and serving as a cofactor for their cleavage.
A Bohne-Lang, A Darcy, A Gaggar, A Hirano, A Maisner, A Segerman, AL Astier, AM Blom, B. David Persson, BD Persson, BD Persson, C Santiago, CJ Buchholz, CL Karp, CR Bebbington, César Santiago, D Hourcade, D Naniche, DG Norman, DJ Gustafsson, E Blanc, E Giannakis, E Giannakis, EM Adams, F Sakurai, F Santoro, Georg Zocher, GJ Arlaud, GN Murshudov, H Kallstrom, H Kallstrom, HL Greenstone, J Wu, JD Fingeroth, JM Bergelson, JM Casasnovas, José M. Casasnovas, K Cupelli, K Iwata, K Iwata, M Marttila, MA Oliver, MD Kirkitadze, Michael Farzan, MK Liszewski, MK Liszewski, MK Liszewski, MK Liszewski, MR Griffiths, Mykol Larvie, N Okada, Nikolaus B. Schmitz, P Emsley, P Stanley, PD Adams, PE Joubert, PJ Kraulis, R Cattaneo, R Read, RC Riley-Vargas, RE Dörig, S Thulke, T Seya, T Stehle, TA Jones, Thilo Stehle, TW Post, Ulrike Scheu, W Kabsch, WL DeLano   +69 more
core   +5 more sources

Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells [PDF]

Journal of Clinical Investigation, 2016
Multiple myeloma is incurable by standard approaches because of inevitable relapse and development of treatment resistance in all patients. In our prior work, we identified a panel of macropinocytosing human monoclonal antibodies against CD46, a negative
Acosta-Alvear, Diego, Aftab, Blake T, Atkinson, John P, Behrens, Christopher R, Hann, Byron C, Liu, Bin, Logan, Aaron C, Martin, Thomas G, Sherbenou, Daniel W, Shuman, Marc A, Su, Yang, Walter, Peter, Wiita, Arun, Wolf, Jeffrey L, Wu, Xiaobo   +14 more
core   +3 more sources

The complement regulatory protein CD46 serves as a novel biomarker for cervical cancer diagnosis and prognosis evaluation [PDF]

Frontiers in Immunology
BackgroundCD46 has been revealed to be a key factor in malignant transformation and cancer treatment. However, the clinical significance of CD46 in cervical cancer remains unclear, and this study aimed to evaluate its role in cervical cancer diagnosis ...
Jun-Hui Yu, Hao-Bo Yuan, Zi-Yi Yan, Xia Zhang, Hui-Hui Xu   +4 more
doaj   +2 more sources

Down-regulation of CD46 by Piliated Neisseria gonorrhoeae [PDF]

, 2003
Human membrane cofactor protein (CD46) protects host cells against complement attack and may function as a receptor for pathogenic Neisseriae. We assessed CD46 expression in the human cervical cell line ME-180 after exposure to Neisseria gonorrhoeae ...
Atkinson, John P., Cannon, Janne G., Gill, Darcy B., Koomey, Michael   +3 more
core   +5 more sources

Quantitative expression analysis of HHV-6 cell receptor CD46 on cells of human cord blood, peripheral blood and G-CSF mobilised leukapheresis cells [PDF]

Virology Journal, 2006
Human herpesvirus-6 (HHV-6) can infect blood cells and thereby may inhibit hematopoietic stem and progenitor cell expansion and differentiation. In this context, it has been discussed if early progenitor cells can be infected by HHV-6.
Nitsche, Andreas, Radonić, Aleksandar, Siegert, Wolfgang, Thulke, Stefanie   +3 more
core   +5 more sources

Molecular Studies and an ex vivo Complement Assay on Endothelium Highlight the Genetic Complexity of Atypical Hemolytic Uremic Syndrome: The Case of a Pedigree With a Null CD46 Variant

Frontiers in Medicine, 2020
Atypical hemolytic uremic syndrome (aHUS) is an ultra-rare disease characterized by microangiopathic hemolysis, thrombocytopenia, and renal impairment and is associated with dysregulation of the alternative complement pathway on the microvascular ...
Rossella Piras, Paraskevas Iatropoulos, Elena Bresin, Marta Todeschini, Sara Gastoldi, Elisabetta Valoti, Marta Alberti, Caterina Mele, Miriam Galbusera, Paola Cuccarolo, Ariela Benigni, Giuseppe Remuzzi, Marina Noris   +12 more
doaj   +2 more sources