Results 141 to 150 of about 35,706 (250)

IgG4 anti‐CD47: Erythrophagocytosis and potential transfusion complications

Transfusion, EarlyView.
Abstract Background IgG4 monoclonal anti‐CD47 for cancer immunotherapy resulted in anemia necessitating red cell (RBC) transfusions. Although the antibody readily binds to CD47 on RBCs, the mechanism underlying the anemia associated with IgG4 is poorly understood.
Kayluz Frias Boligan, Melika Loriamini, Mairead B. Holton, Gurleen Sandhu, Beth Binnington, Randall Velliquette, Connie M. Westhoff, Donald R. Branch   +7 more
wiley   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

CD47, a novel YAP target gene, contributes to hepatic stellate cell activation and liver fibrosis induced by high-fat diet

Heliyon
Activated hepatic stellate cells (HSCs) have been widely recognized as a primary source of pathological myofibroblasts, leading to the accumulation of extracellular matrix and liver fibrosis. CD47, a transmembrane glycoprotein expressed on the surface of
Ya Li, Lin Dong, Xuecui Yin, Xiaohan Wang, Xiaohui Zhu, Pengyuan Zheng, Youcai Tang   +6 more
doaj   +1 more source

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm, Volume 7, Issue 4, April 2026.
Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
wiley   +1 more source

AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane

Translational Oncology
Objectives: Alpha fetoprotein(AFP) overexpression connecting with macrophage dysfunction remain poorly defined. In this study, explore AFP regulates macrophage immunomodulation in hepatocellular carcinoma(HCC) through comprehensive in vitro and in vivo ...
Yinglian Pan, Qiushi Yin, Zhaoliang Wang, Gang Wu, Kun Liu, Xiaowei Li, Jinchen Liu, Jiangzheng Zeng, Bo Lin, Wei Li, Mingyue Zhu, Mengsen Li   +11 more
doaj   +1 more source

Leukocyte surface antigen CD47

, 2013
CD47, also known as integrin-associated protein (IAP), ovarian cancer antigen OA3, Rh-related antigen and MER6, is a widely expressed transmembrane receptor belonging to the immunoglobulin superfamily. CD47 is the counter-receptor for two members of the signal-regulatory protein (SHPS/SIRP) family and a high-affinity receptor for the secreted protein ...
Soto Pantoja, David R, Kaur, Sukhbir, Miller, Thomas W, Isenberg, Jeffrey S, Roberts, David D   +4 more
openaire   +1 more source

Clinical Trial: Early Nivolumab Addition to Regorafenib in Patients With Hepatocellular Carcinoma in Second‐Line (The GOING Trial)

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 7, Page 955-966, April 2026.
In the phase I/IIa GOING trial, an add‐on strategy with regorafenib followed by nivolumab showed a manageable safety profile and meaningful clinical activity in second‐line hepatocellular carcinoma, with a median overall survival of 25 months and 45% three‐year survival in sorafenib‐experienced patients.
Marco Sanduzzi‐Zamparelli, Ana Matilla, José Luis Lledo, Sergio Muñoz‐Martínez, María Varela, Mercedes Iñarrairaegui, Christie Perelló, Beatriz Mínguez, Neus Llarch, Laura Márquez, Antonio Guerrero, Gemma Iserte, Andrés Castaño‐García, Laura Carrión, Marta Fortuny, Jordi Rimola, Ángeles García‐Criado, Gema Domenech, Ferran Torres, José Rios‐Guillermo, Loreto Boix, Esther Samper, Àngels Kateb, Jordi Bruix, Maria Reig   +24 more
wiley   +1 more source

Regulating islet stress responses through CD47 activation

Diabetologia
Abstract Aims/hypothesis Diabetes is a global health burden characterised by incremental beta cell loss. Islet transplantation is a recognised treatment for individuals with type 1 diabetes and hypoglycaemia unawareness but broader application is constrained by limited islet survival and function post-transplantation.
Kale, Atharva, Azar, Mahmoud, Cheng, Vanessa, Robertson, Harry, Coulter, Sally, Mehta, Paulomi M., Julovi, Sohel M., Patrick, Ellis, Ghimire, Kedar, Rogers, Natasha M.   +9 more
openaire   +2 more sources

Beyond PD‐1: Mechanisms of Resistance to Checkpoint Blockade in Classical Hodgkin Lymphoma and Next‐Generation Immune Strategies

European Journal of Haematology, Volume 116, Issue 4, Page 357-367, April 2026.
ABSTRACT PD‐1 inhibitors have reshaped the treatment landscape of classical Hodgkin lymphoma, yet a substantial proportion of patients exhibit primary or acquired resistance driven by tumor‐intrinsic alterations, immunosuppressive microenvironmental signals, metabolic constraints, and EBV‐mediated modulation.
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Xenotransplantation at a Crossroads: Breakthroughs, Challenges, and the Path Forward

Organ Medicine, EarlyView.
Xiaoyu Gan, Jizhang Yu, Jie Wu, Junjie Zong   +3 more
wiley   +1 more source