Results 101 to 110 of about 21,470 (167)

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, Volume 117, Issue 10, Page 2619-2635, October 2026.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

Integrative Single‐Cell Transcriptomics, Multi‐Omics Analyses, and Computational Pharmacology Reveal Macrophage Heterogeneity and the Putative THBS1‐CD36 Axis in Coronary Atherosclerosis

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
Single‐cell and multi‐omics analyses identified THBS1+ macrophages as a terminally differentiated, hypoxia‐adaptive population driving coronary atherosclerosis through THBS1‐CD36 signaling with lymphatic endothelial cells. Targeting CD36 with SMS121 and leveraging a THBS1+ macrophage gene signature enabled therapeutic prediction and accurate risk ...
Jianpeng Li, Xinrui Liu, Run Shi, Lin Yang, Rong Gu   +4 more
wiley   +1 more source

Oxidative Stress, Post‐Translational Modifications, and Type 1 Diabetes Pathogenesis

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Type 1 diabetes (T1D) is an organ‐specific autoimmune disease that destroys insulin‐producing beta‐cells. Insulin is a vital hormone for regulating glycemia that often undergoes post‐translational modifications during processing from pre‐proinsulin to biologically active insulin.
Colleen J. Winstead, Miki Hodel, Hubert M. Tse   +2 more
wiley   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

CD47 and FOXP3⁺ Regulatory Immunity in Colorectal Cancer: A Conceptual Framework for Coordinated Immunosuppression. [PDF]

Cancers (Basel)
Li Q, Poma AM, Tang D, Vignali P, Bruno R, Macerola E, Fuochi B, Ugolini C.   +7 more
europepmc   +1 more source

Dynamic Remodeling of Oocyte‐Granulosa Cell Communication During Bovine Folliculogenesis Revealed by Transcriptomic Meta‐Analyses

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Bidirectional communication between oocytes and granulosa cells undergoes progressive remodeling during bovine folliculogenesis. Integrative transcriptomic analysis identified stage‐specific ligand‐receptor signaling networks coordinating structural, metabolic, and developmental processes.
Noemi Monferini, Ludovica Donadini, Pritha Dey, Federica Franciosi, Valentina Lodde, Maria Belen Rabaglino, Alberto Maria Luciano   +6 more
wiley   +1 more source

Macrophage phagocytosis checkpoints in DLBCL immunotherapy: an evidence-maturity framework from CD47 to CD200. [PDF]

Front Oncol
Qi S, Deng L, Luo S, Yao Y, Chen T.
europepmc   +1 more source

Type 1 diabetes <i>SIRPG</i> risk variants increase SIRP<i>γ</i> expression and CD47 loss enhances CD8⁺ T cell cytotoxicity. [PDF]

NPJ Autoimmun
Sharp RC, Brown ME, Peters LD, Bacher R, Jacobsen LM, Brusko TM.   +5 more
europepmc   +1 more source

Therapeutic biologics interference in serological and pre-transfusion testing. [PDF]

Front Immunol
Trummer P, Habicht CP, Scharberg EA, Schneeweiß C.   +3 more
europepmc   +1 more source

Disruption of the CD47-SIRPα Axis Causes Profound Reduction of Parasitaemia in Mice Infected With Babesia microti. [PDF]

Parasite Immunol
Mohammad S, Brasov I, Gottshall S, Robins S, Rashid S, Bradford R, Molestina RE.   +6 more
europepmc   +1 more source