Results 81 to 90 of about 21,470 (167)

Biomimetic Nano‐Degrader Based CD47‐SIRPα Immune Checkpoint Inhibition Promotes Macrophage Efferocytosis for Cardiac Repair

Advanced Science
CD47‐SIRPα axis is an immunotherapeutic target in tumor therapy. However, current monoclonal antibody targeting CD47‐SIRPα axis is associated with on‐target off‐tumor and antigen sink effects, which significantly limit its potential clinical application.
Jinfeng Gao, Zhiqing Pang, Qiaozi Wang, Yiwen Tan, Qiyu Li, Haipeng Tan, Jing Chen, Wusiman Yakufu, Zhengmin Wang, Hongbo Yang, Jinyan Zhang, Dili Sun, Xueyi Weng, Qibing Wang, Juying Qian, Yanan Song, Zheyong Huang, Junbo Ge   +17 more
doaj   +1 more source

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

miR-96-5p-mediated Inhibition of CD47 contributes to pancreatic tumor regression via activating both innate and adaptive anti-tumor immunity

Cell Communication and Signaling
Blocking immune checkpoints has become a viable immunotherapy option for cancer. CD47, an anti-phagocytic molecule, engages with SIRPα on macrophages to transmit a “don’t eat me” signal, facilitating immunoevasion.
Shoufang Tong, Shushan Hua, Yunling Wu, Xingxing Xiao, Yeqing Leng, Yubin Wang, Mengfan Sun, Jin Li, Xiping Ou, Wenfeng Zhao, Liping Wang, Yingwei Wang, Shuhua Tan   +12 more
doaj   +1 more source

The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma

Cells
The efficacy of immunotherapy in pancreatic ductal adenocarcinoma (PDAC) remains limited. The tumor microenvironment (TME), characterized by the accumulation of suppressive myeloid cells including neutrophils, attributes to immunotherapy resistance in ...
Léon Raymakers, Elsemieke M. Passchier, Meggy E. L. Verdonschot, Mitchell Evers, Chilam Chan, Karel C. Kuijpers, G. Mihaela Raicu, I. Quintus Molenaar, Hjalmar C. van Santvoort, Karin Strijbis, Martijn P. W. Intven, Lois A. Daamen, Jeanette H. W. Leusen, Patricia A. Olofsen   +13 more
doaj   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Engineered Bacterial Outer Membrane Vesicles Hitchhiking on Neutrophils for Antibody Drug Delivery to Enhance Postoperative Immune Checkpoint Therapy

Advanced Science
In clinical practice, surgical removal of tumors often leaves behind small tumors and circulating tumor cells, increasing the risk of metastasis and recurrence, which seriously affects treatment outcomes.
Meng Guan, Xiao‐Ting Xie, Dong Zhou, Kai Cheng, Bin Zhang, Xin‐Yue Xu, Yong Li, Yi‐Tong Zhou, Wei Peng, Li‐Li Chen, Peng‐Shuo Dong, Si Chen, Jia‐Hua Zou, Bo Liu, Yuan‐Di Zhao, Jin‐Xuan Fan   +15 more
doaj   +1 more source

Blockade of SIRPα-CD47 axis by anti-SIRPα antibody enhances anti-tumor activity of DXd antibody-drug conjugates.

PLoS ONE
Signal regulatory protein alpha (SIRPα) is an immune inhibitory receptor on myeloid cells including macrophages and dendritic cells, which binds to CD47, a ubiquitous self-associated molecule.
Mayumi Sue, Takuya Tsubaki, Yoko Ishimoto, Shinko Hayashi, Saori Ishida, Takafumi Otsuka, Yoshitaka Isumi, Yumi Kawase, Junko Yamaguchi, Takashi Nakada, Jun Ishiguro, Kensuke Nakamura, Reimi Kawaida, Toshiaki Ohtsuka, Teiji Wada, Toshinori Agatsuma, Norihito Kawasaki   +16 more
doaj   +1 more source