Results 1 to 10 of about 310,362 (291)

Helminth Antigens Modulate Virus-Induced Activation of CD154 (CD40L) Expression on T Cells in Onchocerca volvulus-Infected Individuals [PDF]

Pathogens
Background: The interaction between helminth and viral infections has important implications for understanding viral disease outcomes and vaccine efficacy in helminth-endemic regions.
Brice Armel Nembot Fogang, Kathrin Arndts, Tomabu Adjobimey, Michael Owusu, Vera Serwaa Opoku, Derrick Adu Mensah, John Boateng, Jubin Osei-Mensah, Julia Meyer, Ute Klarmann-Schulz, Sacha Horn, Inge Kroidl, Alexander Y. Debrah, Achim Hoerauf, Manuel Ritter, Linda B. Debrah   +15 more
doaj   +2 more sources

Cysticercus cellulosae Regulates T-Cell Responses and Interacts With the Host Immune System by Excreting and Secreting Antigens

Frontiers in Cellular and Infection Microbiology, 2021
Cysticercus cellulosae (C. cellulosae) excretes and secretes antigens during the parasitic process to regulate the host immune response; however, resulting immune response and cytokine production in the host during infection still remains unclear.
Xianmin Fan, Yue Zhang, Renhui Ouyang, Bo Luo, Lizhu Li, Wei He, Meichen Liu, Nan Jiang, Fengjiao Yang, Lingjun Wang, Biying Zhou   +10 more
doaj   +1 more source

Comprehensive analysis of mycobacterium tuberculosis antigen-specific CD4+ T cell responses restricted by single HLA class II allotype in an individual

Frontiers in Immunology, 2022
Mycobacterium tuberculosis infection is generally asymptomatic as latent tuberculosis, but it is still known as the world’s leading bacterial cause of death.
Yong-Hun Lee, Yong-Hun Lee, You-Seok Hyun, You-Seok Hyun, Hyeong-A Jo, Hyeong-A Jo, In-Cheol Baek, Sun-Mi Kim, Hyun-Jung Sohn, Tai-Gyu Kim, Tai-Gyu Kim, Tai-Gyu Kim   +11 more
doaj   +1 more source

Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa. [PDF]

, 2013
BACKGROUND: Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define the antigens expressed by Mycobacterium tuberculosis (Mtb), which are ...
AA Odutola, Adane Mihret, Amelia C. Crampin, Andre G. Loxton, BC de Jong, Bonnie A. Thiel, CS Lindestam Arlehamn, Desta Kassa, EM Leyten, Gerhard Walzl, GF Black, GF Black, Gillian F. Black, Harriet Mayanja-Kizza, Hazel M. Dockrell, I Comas, Jayne S. Sutherland, JD Ernst, JS Sutherland, Kees Franken, L Goldsack, Lyn R. Ambrose, Maeve K. Lalor, Marie P. Gomez, Martin Ota, MD Tameris, Michel R. Klein, N Caccamo, N Inokuchi, NN Chegou, Novel N. Chegou, Pere-Joan Cardona, Rawleigh Howe, RL Leistikow, S Commandeur, SH Macdonald, Shreemanta K. Parida, Simon Donkor, Stefan H. E. Kaufmann, TH Ottenhoff, TH Ottenhoff, TH Ottenhoff, Tom H. M. Ottenhoff, W Santema, W. Henry Boom, Willem Hanekom, WY Phong   +46 more
core   +17 more sources

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct

OncoImmunology, 2022
Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S.W. Tan, Yannick Simoni, Evan W. Newell   +10 more
doaj   +1 more source

Identification of CD4+ T cell epitopes in C. burnetii antigens targeted by antibody responses. [PDF]

PLoS ONE, 2011
Coxiella burnetii is an obligate intracellular gram-negative bacterium that causes acute Q fever and chronic infections in humans. A killed, whole cell vaccine is efficacious, but vaccination can result in severe local or systemic adverse reactions ...
Chen Chen, Courtney Dow, Peng Wang, John Sidney, Amanda Read, Allen Harmsen, James E Samuel, Bjoern Peters   +7 more
doaj   +1 more source

Dynamic Adoption of Anergy by Antigen-Exhausted CD4+ T Cells [PDF]

The Journal of Immunology, 2021
Abstract Exhausted immune responses to chronic diseases represent a major challenge to global health. To explore their cell fate and plasticity in exhaustion, we analyzed CD4+T cells in a mouse model with regulatable antigen presentation.
Trefzer, A., Kadam, P., Wang, S.H., Pennavaria, S., Lober, B., Akçabozan, B., Kranich, J., Brocker, T., Nakano, N., Irmler, M., Beckers, J., Straub, T., Obst, R.   +12 more
openaire   +5 more sources

Screening of human tumor antigens for CD4 T cell epitopes by combination of HLA-transgenic mice, recombinant adenovirus and antigen peptide libraries. [PDF]

PLoS ONE, 2010
BACKGROUND: As tumor antigen-specific CD4+ T cells can mediate strong therapeutic anti-tumor responses in melanoma patients we set out to establish a comprehensive screening strategy for the identification of tumor-specific CD4+ T cell epitopes suitable ...
Wolfram Osen, Sabine Soltek, Mingxia Song, Barbara Leuchs, Julia Steitz, Thomas Tüting, Stefan B Eichmüller, Xuan-Duc Nguyen, Dirk Schadendorf, Annette Paschen   +9 more
doaj   +1 more source

Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells [PDF]

, 2010
The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune ...
Gong, Jianlin, Hara, Eiichi, Homma, Sadamu, Koido, Shigeo, Namiki, Yoshihisa, Ohkusa, Toshifumi, Tajiri, Hisao   +6 more
core   +11 more sources

How Thymocyte Deletion in the Cortex May Curtail Antigen-Specific T-Regulatory Cell Development in the Medulla

Frontiers in Immunology, 2022
CD4+ T cell responses to self-antigens are pivotal for immunological self-tolerance. Activation of Foxp3– T-conventional (T-conv) cells can precipitate autoimmune disease, whereas activation of Foxp3+ T-regulatory (T-reg) cells is essential to prevent ...
Chenglong Wang, Stephen R. Daley
doaj   +1 more source