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Intranasal vaccines adjuvanted with Nexavant demonstrate robust protective efficacy by inducing both mucosal and systemic immunity in a murine model. [PDF]

Front Immunol
Ko KH, Bae HS, Lee SM, Park S, Han SH, Heo J, Kim J, Cho Y, Kim DH, Cha SB.   +9 more
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Primary structure of the canine CD4 antigen

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1993
After PCR amplification two overlapping cDNA clones encoding the dog homologue of the human CD4 glycoprotein were identified. This internal fragment of the mature protein including the complete extracellular domains, consists of 1297 bp with a deduced amino acid sequence of 432 residues.
K F, Milde, G E, Conner, D H, Mintz, R, Alejandro   +3 more
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Modulation of CD4 by antigenic activation.

The Journal of Immunology, 1987
Abstract Cell surface expression of CD4, an invariant membrane glycoprotein, is characteristic of the MHC class II-restricted T cell helper/inducer subset. Although the specificity and restriction patterns of T lymphocytes are determined by the T cell receptor for antigen, CD4 might represent an additional "interaction" molecule that is ...
C M, Weyand, J, Goronzy, C G, Fathman
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Antigen Presentation by the CD4 Positive Monocyte Subset

Journal of Leukocyte Biology, 1990
Abstract Although CD4 antigen is expressed on monocytes (MØ), its functional role is uncharacterized. In this study, isolated human MØ were separated into CD4+ and CD4- MØ subsets and assessed for presentation of tetanus toxoid. The CD4- MØ subset had decreased antigen presenting cell (APC) capacity as well as increased PGE2 production ...
Szabo, Gyongyi, Miller-Graziano, Carol L., Kodys, Karen   +2 more
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Characterization of Mouse CD4 TCR and Its Targeting Antigen

2022
The initial step of activation and differentiation of naïve CD4+ T cells is the TCR-antigenic stimulation. The specific antigen peptides (>11 residues) are presented by the class II MHC (MHC II) protein which expresses professional antigen-presenting cells (APCs).
Wenhua, Liang, Feng, Wang
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NEOSPORA CANINUM ANTIGENS DEFINED BY ANTIGEN-DEPENDENT BOVINE CD4⁺T CELLS

Journal of Parasitology, 2005
Neosporosis is an important cause of pregnancy loss in cattle worldwide. The objective of the present study was to identify Neospora caninum antigens as vaccine candidates using antigen-specific, short-term CD4+ T cells established from N. caninum-immunized and -challenged cows. Whole N.
Wenbin, Tuo, Raymond H, Fetterer, William C, Davis, Mark C, Jenkins, J P, Dubey   +4 more
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CD4+ T cell antigen discovery in sarcoidosis

The Journal of Immunology, 2019
Abstract Sarcoidosis is an inflammatory granulomatous disease that primarily affects the lung. It has a worldwide distribution and affects individuals of all ages, races and both sexes. Despite the prevalence of the disease and continued investigation, the cause of sarcoidosis remains unknown.
Sarah A Greaves, Angela Mitchell, Michael Falta, Radleigh Santos, Clemencia A Pinilla, Andrew P Fontenot   +5 more
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Down-regulation of lymphocyte CD4 antigen expression by administration of anti-CD4 monoclonal antibody

Clinical Immunology and Immunopathology, 1992
Modulation of surface CD4 antigen expression was assessed by flow cytometry after calibration with 125I-labeled anti-CD4 monoclonal antibodies (mAbs). Three patients with severe psoriasis treated with BB14 (anti-CD4 mouse IgG1) and five patients with rheumatoid arthritis treated with BL4 (anti-CD4 mouse IgG2a) were analyzed for sequential changes in ...
P, Morel, J F, Nicolas, J, Wijdenes, J P, Revillard   +3 more
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In Vivo Activation of Antigen-Specific CD4 T Cells

Annual Review of Immunology, 2001
Physical detection of antigen-specific CD4 T cells has revealed features of the in vivo immune response that were not appreciated from in vitro studies. In vivo, antigen is initially presented to naïve CD4 T cells exclusively by dendritic cells within the T cell areas of secondary lymphoid tissues.
M K, Jenkins, A, Khoruts, E, Ingulli, D L, Mueller, S J, McSorley, R L, Reinhardt, A, Itano, K A, Pape   +7 more
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