A simple, inexpensive alternative to CD4 counts would facilitate the management of asymptomatic and early symptomatic patients with HIV infection. In this report, a high correlation was found between CD4 counts and total lymphocyte counts calculated from complete blood counts in a cohort of ambulatory HIV-infected patients.
Arthur M. Fournier, Jay M. Sosenko
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CD4 and total lymphocyte counts as predictors of HIV disease progression [PDF]
CD4+ T-lymphocyte (CD4) counts are a standard laboratory marker of disease progression in HIV infection, but expense precludes their use in large parts of the world. Total lymphocyte counts (TLC), in contrast, are widely available. We compared CD4 and TLC counts as predictors of developing AIDS or death in 831 HIV-positive out-patients (582 males and ...
Frank A. Post, Robin Wood, Gary Maartens
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Absolute lymphocyte count as a marker for Cd4 T-lymphocyte count: criterion for initiating antiretroviral therapy in HIV infected Nigerians [PDF]
Few laboratories in resource-constrained countries can afford to perform laboratory-monitoring tests required for the implementation of HIV therapy. In this case control study, we have investigated the relevance of absolute lymphocyte count as a surrogate marker for CD4 lymphocyte count as a criterion for initiating HAARTin HIV-infected Nigerians.A ...
O Erhabor, EK Uko, Teddy Charles Adias
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Absolute Lymphocyte Count Is Not a Suitable Alternative to CD4 Count for Determining Initiation of Antiretroviral Therapy in Fiji [PDF]
Introduction. An absolute lymphocyte count is commonly used as an alternative to a CD4 count to determine initiation of antiretroviral therapy for HIV-infected individuals in Fiji when a CD4 count is unavailable. Methods.
Dashika A. Balak+5 more
doaj +5 more sources
Total lymphocyte count as a surrogate marker for CD4 count in resource-limited settings [PDF]
Background CD4 testing is the recognized gold standard used to stage HIV/AIDS, guide treatment decisions for HIV-infected persons and evaluate effectiveness of therapy.
Obirikorang Christian+2 more
doaj +4 more sources
Background: The high cost of CD4 count estimation in resource-limited settings is a major obstacle in initiating patients on highly active antiretroviral therapy (HAART). Thus, there is a need to evaluate other less expensive surrogate markers like total
Srirangaraj Sreenivasan+1 more
doaj +4 more sources
CD4 lymphocyte count: A barometer for HIV/AIDS management
It is probably not a news to say that HIV/AIDS is yet to have a cure and that the dreaded virus can be managed effectively with highly active antiretroviral therapy (HAART). What is however new is the fact that the point of initiating the management regimen in Africa may likely be different from others elsewhere in the globe if your article recently ...
Nassar A. Sulaiman
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Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients [PDF]
This study evaluated total lymphocyte count (TLC) as a substitute marker for CD4+ cell counts to identify patients who need prophylaxis against opportunistic infection (CD4 < 200 cells/mm(3)) and patients with CD4 < 350 cells/mm(3) (Brazilian threshold value of CD4 count to define AIDS).
Ana Luiza Dias Ângelo+6 more
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Safety and Immunogenicity of H1/IC31®, an Adjuvanted TB Subunit Vaccine, in HIV-Infected Adults with CD4+ Lymphocyte Counts Greater than 350 cells/mm3: A Phase II, Multi-Centre, Double-Blind, Randomized, Placebo-Controlled Trial [PDF]
BACKGROUND: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of ...
Klaus Reither+19 more
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Enumeration of the absolute CD4 T‐lymphocyte count by cell‐bead assay [PDF]
AbstractBackground:We have previously developed an alternative approach for undertaking absolute cell counting based upon flow‐rate calibration using cell bead (FCB), in which cell bead (CB) can be used as a flow‐rate calibration material for generating the absolute microparticle counts.
Duangdao Nantakomol+6 more
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