Results 91 to 100 of about 141,166 (348)

Pre-HAART CD4+ T-lymphocytes as biomarkers of post-HAART immune recovery in HIV-infected children with or without TB co-infection

BMC Infectious Diseases, 2020
Background Infection with the Human Immunodeficiency Virus (HIV) dramatically increases the risk of developing active tuberculosis (TB). Several studies have indicated that co-infection with TB increases the risk of HIV progression and death. Sub-Saharan
Vivek Gopalakrishnan, Eliezer Bose, Usha Nair, Yuwei Cheng, Musie Ghebremichael   +4 more
doaj   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Genomic Variants Associated with Haematological Parameters and T Lymphocyte Subpopulations in a Large White and Min Pig Intercross Population

Animals
The breeding of disease-resistant pigs has consistently been a topic of significant interest and concern within the pig farming industry. The study of pig blood indicators has the potential to confer economic benefits upon the pig farming industry ...
Naiqi Niu, Runze Zhao, Ming Tian, Wencheng Zong, Xinhua Hou, Xin Liu, Ligang Wang, Lixian Wang, Longchao Zhang   +8 more
doaj   +1 more source

The rate of CD4 decline as a determinant of progression to AIDS independent of the most recent CD4 count [PDF]

, 1998
The data of two cohort studies of HIV-infected individuals were used to examine whether the rate of CD4 decline is a determinant of HIV progression, independent of the most recent CD4 count.
Lee, CA, Lepri, AC, Pezzotti, P, Phillips, AN, Rezza, G, Sabin, CA   +5 more
core   +1 more source

Local reference ranges for full blood count and CD4 lymphocyte count testing.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2009
Recent advances in full blood count and CD4 technology, coupled with the changing population demographics of the Gauteng region, have necessitated reevaluation of the reference ranges currently in use.A cross-sectional study of 631 female and 88 male HIV-negative participants from the Gauteng region was performed.
Lawrie, Denise, Coetzee, Lindi Marie, Becker, Piet, Mahlangu, Johnny, Stevens, Wendy, Glencross, Deborah Kim   +5 more
openaire   +3 more sources

Tunable Enhancement of T Cell Expansion Through Modulation of Stiffness and Adhesion Receptor Engagement in an Engineered Hydrogel Platform

Advanced Materials, EarlyView.
We develop a hydrogel scaffold with controlled substrate stiffness and ligand functionalization for cell culture. Stiff substrates presenting CD3/CD28/CD2 ligands induce 2000‐fold expansion of T cells; this is 68% greater than the clinical standard (Dynabeads) and the first hydrogel capable of large‐scale expansion. Although expanding at a lower yield,
Niroshan Anandasivam, Rabia Ali, Lordean Gustinvil, Matthew J. Rosenwasser, Iain E. Dunlop, Derfogail Delcassian   +5 more
wiley   +1 more source

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

Assessment of HIV disease progression before and after initiation of anti­retroviral therapy by CD4 & CD8 T-lymphocyte count and viral load assay

Bangabandhu Sheikh Mujib Medical University Journal, 2016
Backgrounds: As there is no published data regarding the response to Anti-retroviral therapy (ART) among HIV patients from Bangladesh. The present study was designed to determine the immunological and virological responses of HIV infected Bangladeshi ...
Sahina Tabassum, S.M. Rashed-ul Islam, Afzalun Nessa, Munira Jahan, Saif Ullah Munshi   +4 more
doaj   +1 more source

Evaluation of CD4+ T Cells in HIV Patients Presenting with Malaria at the University of Ilorin Teaching Hospital Nigeria [PDF]

, 2009
CD4 count is an important immunological marker of disease progression in HIV seropositive patients. This study was carried out to determine the effect of malaria or fever of unknown origin on the population of CD4+ T lymphocytes of HIV seropositive ...
Louis O. Odeigha, Olajide O. Agbede, Olatunji M. Kolawole, Samuel A. Babatunde, Temitope O. Ajiboye   +4 more
core   +2 more sources

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source