Results 101 to 110 of about 141,166 (348)

CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE. [PDF]

, 2012
BACKGROUND: Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load.
A. Antinori, A. Antoniadou, A. Castagna, A. Castagna, A. Cozzi-Lepri, A. D’, A. Mocroft, A. Mocroft, A. Mocroft, A. Noguera-Julian, A. Phillips, A. Rauch, A. Scherrer, B. Gazzard, B. Ledergerber, C. Colin, C. Leport, C. Lewden, C. Mussini, C. Mussini, C. Sabin, C. Sabin, C. Smit, C. Stephan, C. Stephan, C. Thorne, C. Thorne, C. Torti, C. Torti, C. Torti, D. Costagliola, D. Gibb, D. Haerry, E. Girardi, F. Dabis, F. de Wolf, F. Engsig, F. Gutierrez, F. Raffi, G. Chene, G. Fatkenheuer, G. Touloumi, H. Bucher, H. Bucher, H. Bucher, H. Furrer, H. Furrer, H. Furrer, I. Weller, J. Bohlius, J. Casabona, J. Casabona, J. Del Amo, J. Ghosn, J. Ghosn, J. Grarup, J. Kjaer, J. Miro, J. Munoz, J. Ramos, J. Reekie, J. Sterne, J. Warszawski, J.M. Miro, L. Galli, L. Meyer, L. Meyer, L. Meyer, L. Wittkop, M. Battegay, M. Battegay, M. Dorrucci, M. Egger, M. Fisher, M. Garrido, M. Paulsen, M. Prins, M. Prins, M. Psichogiou, M. Puoti, M. Sharland, M. Sharland, M.M. Krause, N. Brockmeyer, N. Obel, N. Obel, N. Obel, O. Kirk, O. Kirk, O. Kirk, O. Kirk, O. Lambotte, P. Morlat, P. Reiss, P. Reiss, P. Reiss, P. Tookey, R. Lodwick, R. Paredes, R. Teira, R. Thiebaut, R. Zangerle, R. Zangerle, R.Teira, S. Ayayi, S. De Wit, S. Grabar, S. Matheron, S. Perez-Hoyos, T. Goetghebuer, V. Bouteloup, V. Le Moing, V. von Wyl, Y. Young   +113 more
core   +6 more sources

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Characteristics, Determinants, and Clinical Relevance of CD4 T Cell Recovery to <500 Cells/µL in HIV Type 1—Infected Individuals Receiving Potent Antiretroviral Therapy [PDF]

, 2017
Background. The CD4 T cell count recovery in human immunodeficiency virus type 1 (HIV-1)—infected individuals receiving potent antiretroviral therapy (ART) shows high variability. We studied the determinants and the clinical relevance of incomplete CD4 T
Battegay, Manuel, Bernasconi, Enos, Cavassini, Matthias, Furrer, Hansjakob, Hirschel, Bernard, Kaufmann, Gilbert R., Ledergerber, Bruno, Opravil, Milos, Perrin, Luc, Rickenbach, Martin, Vernazza, Pietro   +10 more
core  

Does counseling increase sustained benefit of HAART among prison inmates after release to the community? [PDF]

, 2005
The lack of sustained effectiveness of HAART after release to the community of HIV-infected inmates treated in prison was well demonstrated by Springer et al. in a recent article.
Babudieri, Sergio, Maida, Ivana Rita, Pintus, Antonio, Rezza, Giovanni, Starnini, Giulio   +4 more
core   +1 more source

Parvovirus B19 in HIV+ adult patients with different CD4+ lymphocyte counts

Journal of Medical Microbiology, 2017
Human parvovirus B19 (B19V) can cause anemia in immunocompromised patients. We aimed to investigate the presence of B19V in HIV+ adults with different CD4+ T cell counts, to recognise the frequency of B19V in these different conditions and its possible association with anemia.We studied B19V specific IgM, IgG and DNA in 98 HIV+ patients and in 52 ...
Mauro Sebastian, Pedranti, Gonzalo, Rodriguez-Lombardi, Romina, Bracciaforte, Natalia, Romano, Pablo, Lujan, Brenda, Ricchi, Jorge, Mautino, Maria Pilar, Adamo   +7 more
openaire   +2 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

The association of CD4 lymphocyte count with drug hypersensitivity reaction to highly active antiretroviral therapy, trimethoprim sulfamethoxazole, and antitubercular agents in human immunodeficiency virus patients. [PDF]

Asia Pac Allergy, 2022
Tarranza JLS, Ang MCD.
europepmc   +1 more source

Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host [PDF]

, 1988
We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that CMV infection interferes with the earliest detectable step in hemopoiesis, the generation of the stem cell CFU-S-I, and thereby prevents the ...
Busch, Friedrich W., Bühring, Hans-Jörg, Koszinowski, Ulrich H., Mutter, Wolfgang, Reddehase, Matthias J.   +4 more
core   +2 more sources

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Real World Lab Data: Patterns of Lymphocyte Counts in Fingolimod Treated Patients

Frontiers in Immunology, 2018
Objective:Fingolimod is approved for the treatment of highly active relapsing remitting multiple sclerosis (MS) patients and acts by its unique mechanism of action via sphingosine-1-phosphate receptor-modulation.
Maxi Kaufmann, Rocco Haase, Undine Proschmann, Tjalf Ziemssen, Katja Akgün   +4 more
doaj   +1 more source