Results 1 to 10 of about 812,029 (181)

Human CD4 memory T cells can become CD4+IL-9+ T cells. [PDF]

PLoS ONE, 2010
IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-beta directs mouse CD4(+)CD25(-)CD62L(+) T cells to commit to inflammatory IL-9 producing CD4(+) T cells.Here we show that human ...
Prabhakar Putheti, Amit Awasthi, Joyce Popoola, Wenda Gao, Terry B Strom   +4 more
doaj   +6 more sources

Memory T follicular helper CD4 T cells [PDF]

Frontiers in Immunology, 2015
T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity.
J. Scott eHale, Rafi eAhmed
doaj   +3 more sources

Adaptive-like CAR-iPSC-CD4⁺ T cells outperform CD8⁺ counterparts in sustained ALL control [PDF]

Inflammation and Regeneration
Background Induced pluripotent stem cell (iPSC)–derived T cells offer a renewable source for off-the-shelf immunotherapy. With the advent of the artificial thymic organoid (ATO) method, the in vitro differentiation of CD4+ T cells from iPSCs has also ...
Qingyi Guo, Chaoqi Zhang, Bo Wang, Shoichi Iriguchi, Akihiro Ishikawa, Atsutaka Minagawa, Tomoko Ishii, Yohei Kawai, Shin Kaneko   +8 more
doaj   +2 more sources

Tumor-Specific CD4+ T Cells Restrain Established Metastatic Melanoma by Developing Into Cytotoxic CD4– T Cells

Frontiers in Immunology, 2022
Cytotoxic CD8+ T cells are the main focus of efforts to understand anti-tumor immunity and immunotherapy. The adoptive transfer of tumor-reactive cytotoxic CD8+ T lymphocytes expanded and differentiated in vitro has long been considered the primary ...
Qiao Liu, Lisha Wang, Huayu Lin, Zhiming Wang, Jialin Wu, Junyi Guo, Shuqiong Wen, Ling Ran, Zhengliang Yue, Xingxing Su, Qing Wu, Jianfang Tang, Zhirong Li, Li Hu, Lifan Xu, Lilin Ye, Qizhao Huang, Qizhao Huang   +17 more
doaj   +1 more source

Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites [PDF]

, 2017
Inflammation can be protective or pathogenic depending on context and timeframe. Acute inflammation, including the accumulation of CD4 T cells, accompanies protective immune responses to pathogens, but the presence of activated CD4 T cells at sites of ...
Ammit, Barnden, Brinkmann, Brown, Chimen, Cyster, Debes, Faust, Firestein, Fu, Garrod, Gibson, Han, Hochreiter-Hufford, Hugues, Jo, Karuppuchamy, Kitano, Ledgerwood, Liao, Limaye, Lindquist, Mackay, Mackay, Mammoto, Masopust, Matloubian, Matsuura, McInnes, Means, Mempel, Mendoza, Murphy, Nowarski, Olivera, Priceman, Pyne, Sawicka, Skon, Smith, Spangrude, Tarrason, Teijeira, Tsunemi, Veres, Wang, Wang   +46 more
core   +7 more sources

Circulating activated immune cells as a potential blood biomarkers of non-small cell lung cancer occurrence and progression

BMC Pulmonary Medicine, 2021
Background Treatment for non-small cell lung cancer (NSCLC) has greatly improved in recent years. However, noninvasive early screening for carcinogenesis and progression unclear.
Yingyi Wang, Na Zhou, Rui Zhu, Xiaoyuan Li, Zhao Sun, Yang Gao, Wei Liu, Changting Meng, Yuping Ge, Chunmei Bai, Taisheng Li, Hongsheng Liu   +11 more
doaj   +1 more source

Regulation and gene expression profiling of NKG2D positive human cytomegalovirus-primed CD4+ T-cells. [PDF]

PLoS ONE, 2012
NKG2D is a stimulatory receptor expressed by natural killer (NK) cells, CD8(+) T-cells, and γδ T-cells. NKG2D expression is normally absent from CD4(+) T-cells, however recently a subset of NKG2D(+) CD4(+) T-cells has been found, which is specific for ...
Helle Jensen, Lasse Folkersen, Søren Skov   +2 more
doaj   +1 more source

Failure of CD4 T-cells to respond to liver-derived antigen and to provide help to CD8 T-cells. [PDF]

PLoS ONE, 2011
CD4 T-cell help is required for the induction of efficient CD8 T-cells responses and the generation of memory cells. Lack of CD4 T-cell help may contribute to an exhausted CD8 phenotype and viral persistence.
Katja Derkow, Anja Müller, Ira Eickmeier, Daniel Seidel, Marcos Vicinius Rust Moreira, Nils Kruse, Katja Klugewitz, Justine Mintern, Bertram Wiedenmann, Eckart Schott   +9 more
doaj   +1 more source

IL-15 augments TCR-induced CD4⁺ T cell expansion in vitro by inhibiting the suppressive function of CD25High CD4⁺ T cells [PDF]

, 2012
Due to its critical role in NK cell differentiation and CD8(+) T cell homeostasis, the importance of IL-15 is more firmly established for cytolytic effectors of the immune system than for CD4(+) T cells. The increased levels of IL-15 found in several CD4(
Boonefaes, Tom, Dooms, Hans, Grooten, Johan, Leclercq, Georges, Van Belle, Tom, Wei, Xiao-Qing   +5 more
core   +6 more sources

CD4(+)CD62L(+) central memory T cells can be converted to Foxp3(+) T cells. [PDF]

PLoS ONE, 2013
The peripheral Foxp3(+) Treg pool consists of naturally arising Treg (nTreg) and adaptive Treg cells (iTreg). It is well known that naive CD4(+) T cells can be readily converted to Foxp3(+) iTreg in vitro, and memory CD4(+) T cells are resistant to ...
Xiaolong Zhang, Xian Chang Li, Xiang Xiao, Rui Sun, Zhigang Tian, Haiming Wei   +5 more
doaj   +1 more source