Results 41 to 50 of about 14,389,011 (296)

Alteration of CD4CD25Foxp3 T cell level in Kawasaki disease [PDF]

Korean Journal of Pediatrics, 2011
PurposeExaggerated pro-inflammatory reactions during the acute phase of Kawasaki disease (KD) suggest the role of immune dysregulation in the pathogenesis of KD.
Su Ye Sohn, Young Wooh Song, Yun Ku Yeo, Yun Kyung Kim, Gi Young Jang, Chan Wook Woo, Jung Hwa Lee, Kwang Chul Lee   +7 more
doaj   +1 more source

In vitro induction of regulatory CD4+CD8α+ T cells by TGF-β, IL-7 and IFN-γ. [PDF]

PLoS ONE, 2013
In vitro CD4(+) T cell differentiation systems have made important contributions to understanding the mechanisms underlying the differentiation of naive CD4(+) T cells into effector cells with distinct biological functions.
Luc Van Kaer, Whitney A S Rabacal, Holly M Scott Algood, Vrajesh V Parekh, Danyvid Olivares-Villagómez   +4 more
doaj   +1 more source

In vitro generation of interleukin-10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper 1 (Th1)- and Th2-inducing cytokines [PDF]

, 2002
We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro into regulatory T cells.
Hawrylowicz, C.M., Robert L. Coffman, André Boonstra, Richards, David F, Richards, D.F., Catherine M. Hawrylowicz, Savelkoul, H.F.J., Savelkoul, HFJ (Huub), Crain, Chad, Anne O'Garra, O' Garra, A, de Waal-Malefyt, R., Coffman, R.L., O'Garra, Anne, Cua, D.J., Chad Crain, Cua, DJ, Huub F. Savelkoul, Coffman, RL, Waal-Malefyt, R., de, Cua, Daniel J, Savelkoul, Huub F, Barrat, Franck J, de Waal-Malefyt, René, de Waal-Malefyt, R, Hawrylowicz, Catherine M; id_orcid, Crain, C., Barrat, FJ, Barrat, F.J., Crain, C, Coffman, Robert L, Boonstra, P.A., Daniel J. Cua, Hawrylowicz, CM, Franck J. Barrat, David F. Richards, O'Garra, A., René de Waal-Malefyt, Richards, DF, Boonstra, Andre   +39 more
core   +1 more source

Role of Leptin and metabolism in survival of autoreactive CD4+ T cells [PDF]

, 2009
Recent evidence has shown that leptin, the adipose-tissue derived hormone, can influence T cell homeostasis and survival through the control of genes involved in these processes. Leptin deficient ob/ob mice and humans show reduced circulating number of T
Galgani, Mario
core   +1 more source

Freeze-thaw lysates of Plasmodium falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells. [PDF]

, 2012
In addition to naturally occurring regulatory T (nTreg) cells derived from the thymus, functionally competent Treg cells can be induced in vitro from peripheral blood lymphocytes in response to TCR stimulation with cytokine costimulation.
Finney, Olivia C, Riley, Eleanor M, Finney, OC, Lawrence, Emma, Gray, Alice P, Njie, Madi, Walther, M, Walther, Michael, Riley, EM, Gray, AP, Lawrence, E, Njie, M   +11 more
core   +1 more source

Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4+CD8A+ T cells related to mouse CD4 cytotoxic T cells

Frontiers in Immunology, 2022
Cytotoxic CD4+ T cells (CD4-CTLs) show the presence of cytolytic granules, which include the enzymes granzyme and perforin. The cells have a pathogenic and protective role in various diseases, including cancer, viral infection, and autoimmune disease. In
Shun Tanemoto, Tomohisa Sujino, Kentaro Miyamoto, Kentaro Miyamoto, Jonathan Moody, Yusuke Yoshimatsu, Yoshinari Ando, Ikuko Koya, Yosuke Harada, Anna Okuzawa Tojo, Keiko Ono, Yukie Hayashi, Kaoru Takabayashi, Koji Okabayashi, Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Naoki Hosoe, Haruhiko Ogata, Chung-Chau Hon, Jay W. Shin, Jay W. Shin, Takanori Kanai   +22 more
doaj   +1 more source

IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

, 2012
It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P.
Hunter, Christopher A, Couper, Kevin N, Riley, Eleanor M, Greig, Rachel, Blount, Daniel G, Blount, Daniel G., Stumhofer, Jason S, Hafalla, Julius CR, De Souza, J. Brian, Findlay, Emily Gwyer, Shaw, Tovah N, de Souza, J Brian, Riley, Eleanor M., Shaw, Tovah N., Stumhofer, Jason S., Hunter, Christopher A., Hafalla, Julius C R, Couper, Kevin N., Gwyer Findlay, Emily, Villegas-Mendez, Ana, de, Souza JB, Hunter, CA, Greig, R, Gwyer, Findlay E, Stumhofer, JS, Couper, KN, Blount, DG, Villegas-Mendez, A, Shaw, TN, Hafalla, JC, Riley, EM   +30 more
core   +1 more source

CD4/CD8/Dendritic cell complexes in the spleen: CD8+ T cells can directly bind CD4+ T cells and modulate their response. [PDF]

PLoS ONE, 2017
CD4+ T cell help to CD8+ T cell responses requires that CD4+ and CD8+ T cells interact with the same antigen presenting dendritic cell (Ag+DC), but it remains controversial whether helper signals are delivered indirectly through a licensed DC and/or ...
Aleksandr Barinov, Alessia Galgano, Gerald Krenn, Corinne Tanchot, Florence Vasseur, Benedita Rocha   +5 more
doaj   +1 more source

CD4+ T cells in atherosclerosis

Biomedicine & Pharmacotherapy, 2003
Atherosclerosis is an inflammatory disease. T lymphocytes, occurring concomitantly with macrophages, are found in atherosclerotic lesions with substantial numbers in all stages. Most of the T cells in the lesions are CD4(+) T cells. The finding of activated T cells and macrophages in lesions and cloning of T cells specific for modified low-density ...
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source