Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies. [PDF]
PLoS Pathogens, 2009 The progressive decline of CD4(+) T cells is a hallmark of disease progression in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection.
Takeo Kuwata +9 more
doaj +1 more source
The Journal of Experimental Medicine, 2005 CD4+ T cells continuously monitor antigen levels in their environment and adjust their expansion accordingly, as shown on [page 1555][1]. Obst and colleagues demonstrate that when antigen runs out, CD4+ T cell proliferation stops dead in its tracks.
openaire +1 more source
T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? [PDF]
, 2012 Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively.
Brombacher, F. +5 more
core +4 more sources
Generation and Immune Regulation of CD4+CD25−Foxp3+ T Cells in Chronic Obstructive Pulmonary Disease
Frontiers in Immunology, 2019 The imbalance of CD4+Foxp3+ T cell subsets is reportedly involved in abnormal inflammatory immune responses in patients with chronic obstructive pulmonary disease (COPD).
Jiang-Hua Wu +8 more
doaj +1 more source
The role of CD4+ T cells in tumor and chronic viral immune responses
MedComm, 2023 Immunotherapies are mainly aimed to promote a CD8+ T cell response rather than a CD4+ T cell response as cytotoxic T lymphocytes (CTLs) can directly kill target cells.
Luoyingzi Xie +6 more
doaj +1 more source
T Regulatory Cells Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia [PDF]
Iranian Journal of Immunology, 2020 Background: Drugs used in cancer treatment specifically kill T regulatory cells. Objective: To determine different phenotypes of T regulatory cells during the maintenance phase chemotherapy for pediatric acute lymphoblastic leukemia (ALL).
Marina Nayeli Medina-Rosales +2 more
doaj +1 more source
CD4+T Cells: Differentiation and Functions [PDF]
Clinical and Developmental Immunology, 2012 CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper 1 and T-helper 2, other subsets have been identified,
Rishi Vishal Luckheeram +3 more
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Protective effector memory CD4 T cells depend on ICOS for survival. [PDF]
PLoS ONE, 2011 Memory CD4 T cells play a vital role in protection against re-infection by pathogens as diverse as helminthes or influenza viruses. Inducible costimulator (ICOS) is highly expressed on memory CD4 T cells and has been shown to augment proliferation and ...
Tamson V Moore +8 more
doaj +1 more source
A population of CD62Llow NK1.1− CD4+ T cells that resembles NK1.1+ CD4+ T cells [PDF]
European Journal of Immunology, 1998 In MHC class II-/- C57BL/6 (II-/-) mouse spleen, a small population of CD4+ T cells is present of which NK1.1+ CD4+ (NK) T cells comprise 40 to 45%. We report here that many of the NK1.1- CD4+ T cells derived from II-/- mice are also NK T cells. They produce large amounts of IL-4 in response to anti-CD3 ligation and do so without any requirement for ...
H, Chen, W E, Paul
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The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells [PDF]
, 2007 We have addressed the role of the inducible costimulator (ICOS) in the development of T cell help for B cells and in the generation, survival and reactivation of memory CD4 T cells and B cells.
MacDonald, Andrew +18 more
core +1 more source