Results 21 to 30 of about 14,389,011 (296)

Rapid turnover of effector-memory CD4(+) T cells in healthy humans [PDF]

, 2004
Memory T cells can be divided into central-memory (T(CM)) and effector-memory (T(EM)) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not known whether they are maintained by similar ...
Peter C.L. Beverley, Macallan, DC, Griffin, GE, George E. Griffin, Andrew T. Worth, Derek C. Macallan, Wallace, Diana, Diana Wallace, Ghattas, Hala, Zhang, Yan, Griffin, George E, Macallan, Derek C, Beverley, Peter, Zhang, Y, Ghattas, H, Beverley, Peter CL, Tough, David F, Hala Ghattas, Tough, DF, David F. Tough, De Lara, C, De Lara, Catherine, Beverley, PC, Yan Zhang, Catherine de Lara, Wallace, D, Worth, Andrew T, Worth, AT   +27 more
core   +1 more source

Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies. [PDF]

PLoS Pathogens, 2009
The progressive decline of CD4(+) T cells is a hallmark of disease progression in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection.
Takeo Kuwata, Yoshiaki Nishimura, Sonya Whitted, Ilnour Ourmanov, Charles R Brown, Que Dang, Alicia Buckler-White, Ranjini Iyengar, Jason M Brenchley, Vanessa M Hirsch   +9 more
doaj   +1 more source

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4+ CD25high T cells with susceptibility in Kenyans [PDF]

, 2008
Background - Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection ...
Magdalena Plebanski, Stephen M. Todryk, Todryk, Stephen M., Plebanski Magdalena, Bejon, P, Hill, Adrian, Tabitha Mwangi, Kevin Marsh, Urban Britta, Flanagan Katie L., Mwangi Tabitha, Plebanski, Magdalena, Urban, B, Britta Urban, Todryk, Stephen, Hill Adrian V. S., Urban, Britta, Katie L Flanagan, Flanagan, KL, Hill, AV, Philip Bejon, Bejon, Philip, Marsh Kevin, Marsh, K, Mwangi, T, Mwangi, Tabitha, Flanagan, Katie, Hill, Adrian V. S., Bejon Philip, Plebanski, M, Katie L. Flanagan, Adrian V S Hill, Todryk Stephen M., Adrian V. S. Hill, Stephen M Todryk, Marsh, Kevin, Todryk, SM, Flanagan, Katie L.   +37 more
core   +1 more source

Fueling CD4+ T cells [PDF]

The Journal of Experimental Medicine, 2005
CD4+ T cells continuously monitor antigen levels in their environment and adjust their expansion accordingly, as shown on [page 1555][1]. Obst and colleagues demonstrate that when antigen runs out, CD4+ T cell proliferation stops dead in its tracks.
openaire   +1 more source

Generation and Immune Regulation of CD4+CD25−Foxp3+ T Cells in Chronic Obstructive Pulmonary Disease

Frontiers in Immunology, 2019
The imbalance of CD4+Foxp3+ T cell subsets is reportedly involved in abnormal inflammatory immune responses in patients with chronic obstructive pulmonary disease (COPD).
Jiang-Hua Wu, Mei Zhou, Yang Jin, Zhao-Ji Meng, Xian-Zhi Xiong, Sheng-Wen Sun, Shuai-Ying Miao, Hong-Li Han, Xiao-Nan Tao   +8 more
doaj   +1 more source

The role of CD4+ T cells in tumor and chronic viral immune responses

MedComm, 2023
Immunotherapies are mainly aimed to promote a CD8+ T cell response rather than a CD4+ T cell response as cytotoxic T lymphocytes (CTLs) can directly kill target cells.
Luoyingzi Xie, Jingyi Fang, Juncheng Yu, Weinan Zhang, Zhiqiang He, Lilin Ye, Huaizhi Wang   +6 more
doaj   +1 more source

CD4⁺T Cells: Differentiation and Functions [PDF]

Clinical and Developmental Immunology, 2012
CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper 1 and T-helper 2, other subsets have been identified,
Rishi Vishal Luckheeram, Rui Zhou, Asha Devi Verma, Bing Xia   +3 more
openaire   +3 more sources

T Regulatory Cells Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia [PDF]

Iranian Journal of Immunology, 2020
Background: Drugs used in cancer treatment specifically kill T regulatory cells. Objective: To determine different phenotypes of T regulatory cells during the maintenance phase chemotherapy for pediatric acute lymphoblastic leukemia (ALL).
Marina Nayeli Medina-Rosales, Susana Godina-Gonzalez, Mariana Haydee Garcia-Hernandez   +2 more
doaj   +1 more source

A population of CD62Llow NK1.1− CD4+ T cells that resembles NK1.1+ CD4+ T cells [PDF]

European Journal of Immunology, 1998
In MHC class II-/- C57BL/6 (II-/-) mouse spleen, a small population of CD4+ T cells is present of which NK1.1+ CD4+ (NK) T cells comprise 40 to 45%. We report here that many of the NK1.1- CD4+ T cells derived from II-/- mice are also NK T cells. They produce large amounts of IL-4 in response to anti-CD3 ligation and do so without any requirement for ...
H, Chen, W E, Paul
openaire   +2 more sources

Freeze-thaw lysates of P. falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells. [PDF]

, 2012
: In addition to naturally occurring regulatory T (nTreg) cells derived from the thymus, functionally competent Treg cells can be induced in vitro from peripheral blood lymphocytes in response to T-cell receptor stimulation with cytokine co-stimulation ...
Finney, OC, Walther, M, Riley, EM, Gray, AP, Lawrence, E, Njie, M   +5 more
core   +3 more sources