T regulatory cells in cord blood--FOXP3 demethylation as reliable quantitative marker [PDF]
, 2010 Regulatory T-cells (Tregs), characterized as CD4+CD25(hi) T-cells expressing FOXP3, play a crucial role in controlling healthy immune development during early immune maturation. Recently, FOXP3 demethylation was suggested to be a novel marker for natural
Laura Layland +14 more
core +2 more sources
Frontiers in Immunology, 2016 During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells.
Shintaro eHojyo +11 more
doaj +1 more source
Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection. [PDF]
PLoS Pathogens, 2018 The concerns raised from adenovirus 5 (Ad5)-based HIV vaccine clinical trials, where excess HIV infections were observed in some vaccine recipients, have highlighted the importance of understanding host responses to vaccine vectors and the HIV ...
Sarah Auclair +16 more
doaj +1 more source
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue [PDF]
, 2011 The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria.
Mitchell, T.J. +28 more
core +1 more source
The type of responder T-cell has a significant impact in a human in vitro suppression assay. [PDF]
PLoS ONE, 2010 In type 1 diabetes (T1D), a prototypic autoimmune disease, effector T cells destroy beta cells. Normally, CD4(+)CD25(+high), or natural regulatory T cells (Tregs), counter this assault.
Srikanta Jana +7 more
doaj +1 more source
IL-10 from CD4(+)CD25(-)Foxp3(-)CD127(-) adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection [PDF]
, 2008 The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective pro-inflammatory response can lead to unrestricted parasite replication, whilst failure to ...
Couper, Kevin N +40 more
core +2 more sources
Journal of Neuroinflammation, 2020 Background After peripheral nerve transection, facial motoneuron (FMN) survival depends on an intact CD4+ T cell population and a central source of interleukin-10 (IL-10). However, it has not been determined previously whether CD4+ T cells participate in
Elizabeth M. Runge +5 more
doaj +1 more source
Alteration of CD4CD25Foxp3 T cell level in Kawasaki disease [PDF]
Korean Journal of Pediatrics, 2011 PurposeExaggerated pro-inflammatory reactions during the acute phase of Kawasaki disease (KD) suggest the role of immune dysregulation in the pathogenesis of KD.
Su Ye Sohn +7 more
doaj +1 more source
In vitro induction of regulatory CD4+CD8α+ T cells by TGF-β, IL-7 and IFN-γ. [PDF]
PLoS ONE, 2013 In vitro CD4(+) T cell differentiation systems have made important contributions to understanding the mechanisms underlying the differentiation of naive CD4(+) T cells into effector cells with distinct biological functions.
Luc Van Kaer +4 more
doaj +1 more source
Role of Leptin and metabolism in survival of autoreactive CD4+ T cells [PDF]
, 2009 Recent evidence has shown that leptin, the adipose-tissue derived hormone, can influence T cell homeostasis and survival through the control of genes involved in these processes. Leptin deficient ob/ob mice and humans show reduced circulating number of T
Galgani, Mario
core +1 more source