Results 51 to 60 of about 15,293,201 (302)

Understanding the slow depletion of memory CD4(+) T cells in HIV infection [PDF]

, 2007
Background The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4(+) T cells. Why this decline is slow is not understood.
Nigel Klein, Klein Nigel, Antia, Rustom, Yates, Andrew, Callard, Robin, Antia Rustom, Yates, A, Callard, R, Klein, Nigel, Jaroslav Stark, Stark, J, Andrew Yates, Stark Jaroslav, Rustom Antia, Callard Robin, Stark, Jaroslav, Yates Andrew, Robin Callard, Klein, N, Antia, R   +19 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Freeze-thaw lysates of Plasmodium falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells. [PDF]

, 2012
In addition to naturally occurring regulatory T (nTreg) cells derived from the thymus, functionally competent Treg cells can be induced in vitro from peripheral blood lymphocytes in response to TCR stimulation with cytokine costimulation.
Finney, Olivia C, Riley, Eleanor M, Finney, OC, Lawrence, Emma, Gray, Alice P, Njie, Madi, Walther, M, Walther, Michael, Riley, EM, Gray, AP, Lawrence, E, Njie, M   +11 more
core   +1 more source

Freeze-thaw lysates of P. falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells. [PDF]

, 2012
: In addition to naturally occurring regulatory T (nTreg) cells derived from the thymus, functionally competent Treg cells can be induced in vitro from peripheral blood lymphocytes in response to T-cell receptor stimulation with cytokine co-stimulation ...
Finney, OC, Walther, M, Riley, EM, Gray, AP, Lawrence, E, Njie, M   +5 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF alpha therapy [PDF]

, 2004
Regulatory T cells have been clearly implicated in the control of disease in murine models of autoimmunity. The paucity of data regarding the role of these lymphocytes in human autoimmune disease has prompted us to examine their function in patients with
Jamie G. Evans, Gary Warnes, Mauri, C, Isenberg, DA, Warnes, G, Samantha Moore, Michael R. Ehrenstein, Evans, JG, Moore, S, Singh, A, David A. Isenberg, Claudia Mauri, Ehrenstein, MR, Animesh Singh   +13 more
core   +1 more source

Impaired immune reconstitution in HIV infection: the role of CD4+ T-cell-associated NKG2D ligands, CD4+ T-cell subsets imbalance, and immune function deficiency

Frontiers in Immunology
ObjectiveThe role of natural killer (NK) cells, which mediate innate immunity, in the immune reconstitution of people living with HIV (PLWH) remains unclear.
Qianqian Xu, Qianqian Xu, Qiuyue Zhang, Peng Xu, Peng Xu, Tong Zhang, Tong Zhang, Hao Wu, Hao Wu, Xin Zhang, Xin Zhang, Christiane Moog, Christiane Moog, Bin Su, Bin Su   +14 more
doaj   +1 more source

CD4+ and CD8+ T Cell Activation Are Associated with HIV DNA in Resting CD4+ T Cells

PLoS ONE, 2014
The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers ...
Cockerham, Leslie R, Siliciano, Janet D, Sinclair, Elizabeth, O'Doherty, Una, Palmer, Sarah, Yukl, Steven A, Strain, Matt C, Chomont, Nicolas, Hecht, Frederick M, Siliciano, Robert F, Richman, Douglas D, Deeks, Steven G   +11 more
openaire   +6 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity [PDF]

, 2012
In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.
Ciudad i Gómez, Carlos Julián, Castellote i Bargalló, M. Cristina, Castell, Margarida, Noé Mata, Verónica, Rabanal i Tornero, Manel, Pelegrí, Carme, Franch, Àngels   +6 more
core   +1 more source