Results 91 to 100 of about 812,049 (201)

CD4 T cell responses to flaviviruses

Journal of Clinical Virology, 2018
Flaviviruses pose an increasing threat to global health with their potential to cause severe disease in millions of people. Protective and long-lived immunity is closely linked to the generation of CD4 T cells, which provide B cell help and support high affinity neutralizing antibody responses.
Judith H. Aberle, Maximilian Koblischke, Karin Stiasny   +2 more
openaire   +3 more sources

Tumor-released autophagosomes induces CD4+ T cell-mediated immunosuppression via a TLR2–IL-6 cascade

Journal for ImmunoTherapy of Cancer, 2019
Background CD4+ T cells are critical effectors of anti-tumor immunity, but how tumor cells influence CD4+ T cell effector function is not fully understood.
Yong-Qiang Chen, Peng-Cheng Li, Ning Pan, Rong Gao, Zhi-Fa Wen, Tian-Yu Zhang, Fang Huang, Fang-Yuan Wu, Xi-Long Ou, Jin-Ping Zhang, Xue-Jun Zhu, Hong-Ming Hu, Kang Chen, Yun-Lang Cai, Li-Xin Wang   +14 more
doaj   +1 more source

INNOVATIVE STRATEGIES TO IDENTIFY M. TUBERCULOSIS ANTIGENS AND EPITOPES USING GENOME-WIDE ANALYSES

Frontiers in Immunology, 2014
In view of the fact that only a small part of the Mtb expressome has been explored for identification of antigens capable of activating human T-cell responses, which is critically required for the design of better TB vaccination strategies, more emphasis
Annemieke eGeluk, Krista E van Meijgaarden, Simone A Joosten, Susanna eCommandeur, Susanna eCommandeur, Tom H.M. Ottenhoff   +5 more
doaj   +1 more source

PENGARUH KOMBINASI CYCLOPHOSPHAMIDE - TRANSFER FACTOR TERHADAP SKOR SEL T CD4+ PADA ADENOCARSINOMA MAMMAE MENCIT C3H [PDF]

, 2011
Background : Transfer factor are extracts from Colostrum, which is considered as an immunostimulant oligoribonukleotida for alternative therapies. Breast cancer patients will experience a decline in the immune system.
Shodiq, M Ali
core  

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides. [PDF]

, 2018
Tissue-specific autoimmunity occurs when selected antigens presented by susceptible alleles of the major histocompatibility complex are recognized by T cells.
Anderson, Mark S, Lichti, Cheryl F, Santambrogio, Laura, Taniguchi, Ruth, Unanue, Emil R, Vomund, Anthony N, Wan, Xiaoxiao, Zakharov, Pavel N, Zinselmeyer, Bernd H   +8 more
core  

Implications of accumulation of clonally expanded and senescent CD4+GNLY+ T cells in immunological non-responders of HIV-1 infection

Emerging Microbes and Infections
Increased CD4+GNLY+ T cells have been confirmed to be inversely associated with CD4+ T cell count in immunological non-responders (INRs), however, the underlying mechanisms are unknown.
Xiuhan Yang, Cheng Zhen, Huihuang Huang, Yanmei Jiao, Xing Fan, Chao Zhang, Jinwen Song, Songshan Wang, Chunbao Zhou, XinXin Yang, Jinhong Yuan, Jiyuan Zhang, Ruonan Xu, Fu-Sheng Wang   +13 more
doaj   +1 more source

Re-centauring T cell antigen discovery around CD4+ T cells

Cell Reports Methods
In a recent issue of Cell, Dezfulian et al. develop a genome-scale platform to enable high-throughput identification of CD4+ T cell epitopes. This platform enables unbiased screens to discover antigens recognized by CD4+ T cells in cancer, infectious diseases, and autoimmunity.
Smith, Blake E., Chan, Amanda O., Birnbaum, Michael E.   +2 more
openaire   +2 more sources

Editorial: Cytotoxic CD4+ T Cells in Viral Infections

Frontiers in Immunology, 2017
Chansavath Phetsouphanh, Shiv Pillai, John J. Zaunders, John J. Zaunders   +3 more
doaj   +1 more source

Immunity to self co-generates regulatory T cells [PDF]

, 2008
Immune responses to self are kept in check by tolerance mechanisms, including suppression by regulatory T cells (Tregs). The defective generation of Tregs specific for self-antigens may lead to autoimmune disease.
Bo Han Lee, Daniel J. Thearle, Helen E. Young, James A. Dromey, Kent P. Jensen, Larissa Belov, Leonard C. Harrison, Spiros Fourlanos, Stuart I. Mannering   +8 more
core   +1 more source

Targeting PD-1 and CD85j can restore intratumoral CD4+ GzmB+ T-cell functions to combat MHC-II-expressing tumors

Journal for ImmunoTherapy of Cancer
Background A subset of CD4+ T cells with cytotoxic activity has been identified, and these cells exert their effects by expressing perforin and granzymes.
Xue Wang, Xu Wang, WenBin Zou, Zhiwei Yuan, Hui Xiong, Xiangning Fu, Lequn Li, Yu Xi, Boyu Wang, Tianlai Wang, Kelin Meng, Taiyan Yu, Shaojie Hu, Rirong Qu, Chenxi Zeng, Yitao Tian, Yixin Cai, Shengling Fu   +17 more
doaj   +1 more source