Results 61 to 70 of about 812,049 (201)

Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta [PDF]

, 2007
The induction of regulatory T (T reg) cells holds considerable potential as a treatment for autoimmune diseases. We have previously shown that CD4(+)CD25(hi) T reg cells isolated from patients with active rheumatoid arthritis (RA) have a defect in their ...
Ehrenstein, MR, Mauri, C, Nadkarni, S
core  

Immune checkpoints in circulating and tumor-Infiltrating CD4 + T Cell Subsets in Colorectal cancer patients [PDF]

, 2019
Blockade of inhibitory immune checkpoints (ICs) is a promising therapeutic approach; however, it has shown limited success in some cancers including colorectal cancer (CRC). The tumor microenvironment (TME) is largely responsible for response to therapy,
Abu Nada, M, Al-Dhaheri, M, Elkord, E, Khawar, M, Murshed, K, Toor, SM   +5 more
core   +2 more sources

Pathological proliferation: a potential mechanism for poor CD4+ T cell recovery in people living with HIV

Frontiers in Cellular and Infection Microbiology
BackgroundPeople living with HIV (PLWH) fail to achieve normalization of CD4+ T cell counts and function, especially in immunological non-responders (INRs).
Yang Zhang, Yang Zhang, Jiahao Ji, Kaidi Xie, Miaotian Cai, Miaotian Cai, Rui Wang, Rui Wang, Xin Zhang, Xue Chen, Yulin Zhang, Yulin Zhang, Hao Wu, Wen Wang, Wen Wang, Zhen Li, Zhen Li, Tong Zhang, Tong Zhang, Tong Zhang   +19 more
doaj   +1 more source

Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes

Clinical and Developmental Immunology, 2013
Pathobiology of type 1 diabetes (T1D) is predominantly associated with T-cell-related actions. Homeostasis of majority of T-cells is critically dependent on signals mediated by CD127 (interleukin-7 receptor, IL-7R).
Marcin Moniuszko, Barbara Glowinska-Olszewska, Malgorzata Rusak, Marta Jeznach, Kamil Grubczak, Danuta Lipinska, Robert Milewski, Anna Justyna Milewska, Milena Dabrowska, Ewa Jablonska, Adam Kretowski, Maria Gorska, Anna Bodzenta-Lukaszyk, Artur Bossowski   +13 more
doaj   +1 more source

Preclinical Development and Clinical-Scale Manufacturing of HIV Gag-Specific, LentivirusModified CD4 T Cells for HIV Functional Cure

Molecular Therapy: Methods & Clinical Development, 2020
Activation, infection, and eventual depletion of human immunodeficiency virus (HIV)-specific cluster of differentiation 4 (CD4) T cells are the crucial pathogenetic events in acquired immunodeficiency syndrome (AIDS). We developed a cell and gene therapy
Haishan Li, Tyler Lahusen, Lingzhi Xiao, Nidal Muvarak, Jana Blazkova, Tae-Wook Chun, C. David Pauza   +6 more
doaj   +1 more source

Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. [PDF]

, 2018
Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4+ T cells.
Borlido, Joana, Bradley, Linda M, Carrette, Florent, D'Angelo, Maximiliano A, Raices, Marcela, Sakuma, Stephen, Tinoco, Roberto   +6 more
core   +1 more source

Plasticity of CD4+ FoxP3+ T cells [PDF]

Current Opinion in Immunology, 2009
Regulatory T (Treg) cells play an essential role in maintaining immunological tolerance. The discovery of FoxP3 as a key Treg transcription factor combined with recent advances in the development of functional reporter mice has enabled new insights into Treg biology and revealed unexpected features of this lineage.
Zhou, Xuyu, Bailey-Bucktrout, Samantha, Jeker, Lukas T., Bluestone, Jeffrey A.   +3 more
openaire   +3 more sources

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function. [PDF]

, 2019
Objective: We have previously shown that increased circulating interleukin-6 (IL-6) results in enhanced CD4+ T cell signaling via signal transduction and activator of transcription-3 (STAT3) in early rheumatoid arthritis (RA).
Aletaha, Alonzi, Anderson, Anderson, Arnett, Atsumi, Bettelli, Charlot-Rabiega, Chen, Choy, Dienz, Filer, Genovese, Heinrich, Hidalgo, Hunter, Isomaki, Jones, Karlson, Kokkonen, Kremer Joel, Kuuliala, Lawson, Liu, Manel, Ohshima, Pratt, Purvis, Purvis, Ridgley, Rincón, Sallusto, Smolen, Unutmaz   +33 more
core   +2 more sources

Iron controls T helper cell pathogenicity by promoting glucose metabolism in autoimmune myopathy

Clinical and Translational Medicine, 2022
Background T helper cells in patients with autoimmune disease of idiopathic inflammatory myopathies (IIM) are characterized with the proinflammatory phenotypes. The underlying mechanisms remain unknown.
Yimei Lai, Siyuan Zhao, Binfeng Chen, Yuefang Huang, Chaohuan Guo, Mengyuan Li, Baokui Ye, Shuyi Wang, Hui Zhang, Niansheng Yang   +9 more
doaj   +1 more source

CD4+ T cells in atherosclerosis

Biomedicine & Pharmacotherapy, 2003
Atherosclerosis is an inflammatory disease. T lymphocytes, occurring concomitantly with macrophages, are found in atherosclerotic lesions with substantial numbers in all stages. Most of the T cells in the lesions are CD4(+) T cells. The finding of activated T cells and macrophages in lesions and cloning of T cells specific for modified low-density ...
openaire   +2 more sources