Results 21 to 30 of about 7,063 (170)

PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism [PDF]

Cellular Signalling, 2014
Phorbol-12-myristate-13-acetate, also called PMA, is a small molecule that activates protein kinase C and functions to differentiate hematologic lineage cells. However, the mechanism of PMA-induced cellular differentiation is not fully understood. We found that PMA triggers global enhancement of protein ubiquitination in K562, a myelogenous leukemia ...
Chonghua, Li, Natoya, Peart, Zhenyu, Xuan, Dorothy E, Lewis, Yang, Xia, Jianping, Jin   +5 more
openaire   +2 more sources

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age

Cell Reports, 2018
Summary: Long-term hematopoietic stem cells (LT-HSCs) maintain hematopoietic output throughout an animal’s lifespan. However, with age, the balance is disrupted, and LT-HSCs produce a myeloid-biased output, resulting in poor immune responses to ...
Mati Mann, Arnav Mehta, Carl G. de Boer, Monika S. Kowalczyk, Kevin Lee, Pearce Haldeman, Noga Rogel, Abigail R. Knecht, Daneyal Farouq, Aviv Regev, David Baltimore   +10 more
doaj   +1 more source

Overexpression of CD61 promotes hUC‐MSC differentiation into male germ‐like cells [PDF]

Cell Proliferation, 2016
AbstractObjectivesPrevious studies have shown that germ‐like cells can be induced from human umbilical cord mesenchymal stem cell (hUC‐MSCs) in vitro. However, induction efficiency was low and a stable system had not been built. CD61, also called integrin‐β3, plays a significant role in cell differentiation, in that CD61‐positive‐cell‐derived ...
Bo, Li, Weishuai, Liu, Mengru, Zhuang, Na, Li, Siyu, Wu, Shaohui, Pan, Jinlian, Hua   +6 more
openaire   +2 more sources

EXPRESSION OF CD41 (GPIIB) AND CD61 (GPIIIA) IN PATIENTS WITH GLANZMANN THROMBASTHENIA USING FLOW CYTOMETRY

The Iraqi Journal of Medical Sciences, 2017
Background: Many genetic mutations causing severe reduction or defect in GPIIb (CD41) and/or GPIIIa (CD61) receptors in Glanzmann Thrombasthenia (G.T.).
Hala O. Hassan, Subh S. Al-Mudalal, Yusra G. Alubaidy, Nidal K. Al-Rahal   +3 more
doaj   +6 more sources

A Long-Lived Luminal Subpopulation Enriched with Alveolar Progenitors Serves as Cellular Origin of Heterogeneous Mammary Tumors

Stem Cell Reports, 2015
It has been shown that the mammary luminal lineage could be maintained by luminal stem cells or long-lived progenitors, but their identity and role in breast cancer remain largely elusive.
Luwei Tao, Maaike P.A. van Bragt, Zhe Li   +2 more
doaj   +1 more source

ACE2 protein expression in lung tissues of severe COVID-19 infection

Scientific Reports, 2022
Angiotensin-converting enzyme 2 (ACE2) is a key host protein by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters and multiplies within cells. The level of ACE2 expression in the lung is hypothesised to correlate with an increased
Atish Gheware, Animesh Ray, Deeksha Rana, Prashant Bajpai, Aruna Nambirajan, S. Arulselvi, Purva Mathur, Anjan Trikha, Sudheer Arava, Prasenjit Das, Asit Ranjan Mridha, Geetika Singh, Manish Soneja, Neeraj Nischal, Sanjeev Lalwani, Naveet Wig, Chitra Sarkar, Deepali Jain   +17 more
doaj   +1 more source

Megakaryocytes respond during sepsis and display innate immune cell behaviors

Frontiers in Immunology, 2023
Megakaryocytes (MKs) are precursors to platelets, the second most abundant cells in the peripheral circulation. However, while platelets are known to participate in immune responses and play significant functions during infections, the role of MKs within
Galit H. Frydman, Galit H. Frydman, Felix Ellett, Julianne Jorgensen, Anika L. Marand, Lawrence Zukerberg, Martin K. Selig, Shannon N. Tessier, Keith H. K. Wong, David Olaleye, Charles R. Vanderburg, James G. Fox, Ronald G. Tompkins, Daniel Irimia   +13 more
doaj   +1 more source

Expression of CD61 (β₃integrin subunit) on canine cells

Platelets, 2001
A monoclonal antibody (JM2E5) specific for the integrin beta3 chain, or CD61 or GPIIIa subunit, has been employed to determine the expression of the canine homologue CD41/CD61 or CD51/CD61 complex on different canine cells in peripheral blood lymphocytes, monocytes, granulocytes, platelets, erythrocytes, lymph-node cells, spleen cells and breast tumour
C, Arce, A, Moreno, J M, Pérez de la Lastra, J J, Garrido, M, Barbancho, D F, De Andrés, L, Morera, D, Llanes   +7 more
openaire   +2 more sources

Novel homozygous silent mutation of ITGB3 gene caused Glanzmann thrombasthenia

Frontiers in Pediatrics, 2023
Glanzmann thrombasthenia (GT) is a rare inherited disease characterized by mucocutaneous bleeding due to the abnormalities in quantity or quality of platelet membrane GP IIb (CD41) or GP IIIa (CD61). GP IIb and GP IIIa are encoded by the ITGA2B and ITGB3
Zhengrong Wang, Zhengrong Wang, Yuqing Xu, Yuqing Xu, Yixi Sun, Yixi Sun, Shuang Wang, Shuang Wang, Minyue Dong, Minyue Dong   +9 more
doaj   +1 more source

Dynamic Susceptibility Contrast Magnetic Resonance Imaging with Carbon-Encapsulated Iron Nanoparticles Navigated to Integrin Alfa V Beta 3 Receptors in Rat Glioma

Nanomaterials
Overexpression of αvβ3 integrin is found in a diverse group of tumors originating from glial cells in the brain, making this transmembrane receptor a promising biomarker for molecular MRI diagnosis.
Agnieszka Stawarska, Magdalena Bamburowicz-Klimkowska, Wojciech Szeszkowski, Ireneusz Piotr Grudzinski   +3 more
doaj   +1 more source