Results 1 to 10 of about 198,996 (143)

Acute SARS-CoV-2 pneumonitis with cytotoxic CD8 positive T-lymphocytes: Case report and review of the literature. [PDF]

Pathol Res Pract, 2021
As of October 2020, there are over 40 million confirmed cases, and more than 1 million confirmed deaths of Covid-19 worldwide. The main cause of death in hospitalized patients is a respiratory failure due to acute respiratory distress syndrome. It has been suggested that the very intense immune response induces diffuse alveolar damage that far exceeds ...
Puzyrenko A, Felix JC, Sun Y, Rui H, Sheinin Y.   +4 more
europepmc   +3 more sources

High level of EZH2 expression is linked to high density of CD8-positive T-lymphocytes and an aggressive phenotype in renal cell carcinoma. [PDF]

World J Urol, 2021
Abstract Purpose Enhancer of zeste homolog 2 (EZH2), the catalytic part of the Polycomb repressive complex 2 (PRC2), has a prognostic role in renal cell carcinoma (RCC) and was recently shown to modulate the immune response by reducing tumor cell immunogenicity.
Eichenauer T, Simmendinger L, Fraune C, Mandelkow T, Blessin NC, Kluth M, Hube-Magg C, Möller K, Clauditz T, Weidemann S, Dahlem R, Fisch M, Riechardt S, Simon R, Sauter G, Büscheck F, Rink M.   +16 more
europepmc   +5 more sources

CD39 Expression in Peripheral T Cells is Associated with Clinicopathological Characteristics in Patients with Cervical Cancer [PDF]

Iranian Journal of Immunology, 2023
Background: CD39 is an inhibitory checkpoint exerting rate-limiting effects on the ATP-adenosine pathway. It can be targeted to block adenosine-mediated immunosuppression.Objective: To analyze the relationship between the CD39 expression and ...
Kuo Zhao, Dongmei Han, Lu Tang, Hao Jin
doaj   +1 more source

The Relationship of CD8-Positive Cytotoxic T Lymphocytes and other Clinicopathologic Features with Survival in Breast Cancer

مجله دانشکده پزشکی اصفهان, 2017
Background: CD8-positive T lymphocytes are important part of cell-mediated immunity and play a central role in induction of immune response against tumor progression.
Simin Hemati, Mitra Heidarpour, Awat Feizi, Fatemeh Abootalebian   +3 more
doaj   +1 more source

CD8 Positive T Lymphocyte Infiltration of Liver Metastases of Uveal Melanoma: A Case Report [PDF]

Frontiers in Oncology, 2021
A 78-year-old Japanese man was referred for examination of multiple small nodules on his liver detected by magnetic resonance imaging (MRI). These small nodules were hyperintense on T1-weighted MRI, and were in hepatobiliary phase on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced MRI.
Naoki Takahashi, Kazuto Tajiri, Ko Kagoyana, Shinichi Tanaka, Ichiro Yasuda   +4 more
openaire   +3 more sources

Aerobic training modulates T cell activation in elderly women with knee osteoarthritis [PDF]

Brazilian Journal of Medical and Biological Research, 2016
Osteoarthritis of the knee (kOA) is a disease that mainly affects the elderly and can lead to major physical and functional limitations. However, the specific effects of walking, particularly on the immune system, are unknown. Therefore, this study aimed
W.F. Gomes, A.C.R. Lacerda, G.E.A. Brito-Melo, S.F. Fonseca, E. Rocha-Vieira, A.A.O. Leopoldino, M.R. Amorim, V.A. Mendonça   +7 more
doaj   +3 more sources

CD39 molecule: a negative regulator expressed on T cells in patients with lung adenocarcinoma

Archives of Medical Science, 2023
Introduction The function of cytotoxic cells may be impacted by CD39 expression on CD8-positive T lymphocytes, leading to an imbalance in tumor immunity.
Lu Tang, Hao Jin
doaj   +1 more source

Cytotoxic CD8-positive T-lymphocyte infiltration in the lungs as a histological pattern of SARS-CoV-2 pneumonitis [PDF]

Pathology, 2022
Despite millions of PCR confirmed cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, the long-term pathophysiological changes induced by this infection in the lungs and their relationship with possible immune triggers remain incompletely understood. Acute respiratory distress syndrome and subsequent respiratory failure are
Puzyrenko, Andrii, Felix, Juan C., Ledeboer, Nathan A., Sun, Yunguang, Rui, Hallgeir, Sheinin, Yuri   +5 more
openaire   +2 more sources

CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity [PDF]

Journal of Virology, 1987
We have shown in a murine model system for acute, lethal cytomegalovirus (CMV) disease in the immunocompromised natural host that control of virus multiplication in tissues, protection from virus-caused tissue destruction, and survival are mediated by virus-specific CD8+ CD4-T lymphocytes.
Reddehase, Matthias J., Mutter, Wolfgang, Münch, Konrad, Bühring, Hans-Jörg, Koszinowski, Ulrich H.   +4 more
openaire   +3 more sources

Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19

Journal of Intensive Care, 2021
We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry.
Yumi Mitsuyama, Kazuma Yamakawa, Katsuhide Kayano, Miho Maruyama, Takeshi Wada, Satoshi Fujimi   +5 more
doaj   +1 more source