Results 141 to 150 of about 88,420 (193)

CD86+/CD206+, Diametrically Polarized Tumor-Associated Macrophages, Predict Hepatocellular Carcinoma Patient Prognosis

International Journal of Molecular Sciences, 2016
Tumor-associated macrophages (TAMs), the most abundant infiltrating immune cells in tumor microenvironment, have distinct functions in hepatocellular carcinoma (HCC) progression. CD68+ TAMs represent multiple polarized immune cells mainly containing CD86+
Ling Dong, She Chen, Si Zhang
exaly   +2 more sources

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CD28–CD80/CD86 Interactions in Testicular Immunoregulation

Journal of Reproductive Immunology, 1996
The expression of two accessory molecules on antigen-presenting cells (APC), the CD80/ B7-1 and CD86/B7-2 antigens, was studied in the testis of normal and non-obese diabetic (NOD) mice. In addition, the effect of CD28 stimulation on suppression of lymphocytes by testicular products was investigated.
Pasi Pöllänen, O Simell, Olli Simell
exaly   +3 more sources

Interactions of CD80 and CD86 with CD28 and CTLA4

The Journal of Immunology, 1996
Abstract CD80 and CD86 are cell surface glycoproteins expressed on a variety of professional APCs. They have attracted much attention due to their function as potent costimulators of T lymphocyte function through their interaction with CD28 and possibly CTLA4. Because inhibitors of this interaction may have therapeutic relevance in human
J H, Ellis, M N, Burden, D V, Vinogradov, C, Linge, J S, Crowe   +4 more
openaire   +2 more sources

The levels of serum soluble CD86 are correlated with the expression of CD86 variant 3 gene and are prognostic indicators in patients with myeloma

Experimental Hematology, 2023
We previously showed that cell-surface CD86 expressed on multiple myeloma (MM) cells contributed to not only tumor growth but also antitumor cytotoxic T-lymphocyte responses mediated by induction of IL-10-producing CD4+ T cells. The soluble form of CD86 (sCD86) was also detected in serum from patients with MM.
Ryosuke Kinoshita, Mariko Ishibashi, Hiroshi Handa, Makoto Sasaki, Yoichi Imai, Norina Tanaka, Shigeki Ito, Mika Sunakawa-Kii, Yuta Kaito, Toshio Asayama, Norio Komatsu, Junji Tanaka, Takeshi Odajima, Hiroki Sugimori, Hiroki Yamaguchi, Koiti Inokuchi, Hideto Tamura   +16 more
openaire   +2 more sources

The Role of Talaromyces Marneffei Binding To CD86 in the CD86-CTLA4 Regulatory Pathway

Current Microbiology
Talaromyces marneffei (TM), an opportunistic pathogenic fungus, binds to CD86, which acts as a co-stimulatory molecule for CTLA4. CD86 activates CTLA4, which transmits inhibitory signals, yet its role in TM immune responses remains unclear. In this study, we investigated how the binding of TM to CD86 modulates the CD86-CTLA4 regulatory pathway.
Shangrong, Tang, Krishna, Hamal, Yongjun, Meng, Meilan, Xu, Donghua, Liu   +4 more
openaire   +2 more sources

CD86  + 1057G/A Polymorphism and Susceptibility to Osteosarcoma

DNA and Cell Biology, 2011
CD86 (B7-2), one of the costimulatory molecules on antigen-presenting cells, plays essential roles not only in autoimmunity and transplantation but also in tumor immunity. CD86  + 1057G/A polymorphism (rs1129055) is associated with various diseases.
Wen, Wang, Haihan, Song, Jie, Liu, Bao, Song, Xuecheng, Cao   +4 more
openaire   +2 more sources

Reduced monocyte CD86 expression in postinflammatory immunodeficiency

Critical Care Medicine, 2007
Major surgery, polytrauma, stroke, and pancreatitis frequently lead to a compensatory anti-inflammatory response syndrome that often predisposes patients to lethal infections. This temporary postinflammatory immunodeficiency is characterized by altered function of blood monocytes.
Kerstin, Wolk, Conny, Höflich, Heidrun, Zuckermann-Becker, Wolf-Dietrich, Döcke, Hans-Dieter, Volk, Robert, Sabat   +5 more
openaire   +2 more sources

Regulation of self-tolerance by CD80/CD86 interactions

Current Opinion in Immunology, 1997
Antigen presentation by CD80/CD86-positive 'professional APCs' induces T-cell activation, whereas antigen presentation in the absence of sufficient CD80/CD86 costimulation may induce a form of tolerance. Blocking CD80/CD86 constimulation inhibits autoimmune disease progression in a variety of animal models, but whether these effects result from ...
P, Lu, Y L, Wang, P S, Linsley
openaire   +2 more sources