Results 151 to 160 of about 88,420 (193)
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The role of B7-2 (CD86) in tumour immunity
Expert Opinion on Investigational Drugs, 1997Tumour cells engineered to express co-stimulatory molecules on their surface provide researchers with powerful new tools to manipulate antitumour responses. It has been demonstrated that B7-1+ and B7-2+ tumour cells can elicit effective responses against their wild-type counterparts.
G, Yang, K E, Hellström, L, Chen
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CD86 gene variants and susceptibility to pancreatic cancer
Journal of Cancer Research and Clinical Oncology, 2012Pancreatic cancer is one of the most lethal cancers worldwide. CD86 (B7-2) is a costimulatory molecule on antigen-presenting cells and plays critical roles in tumor immunity. It has been reported that polymorphisms in CD86 gene can be involved in the development of various cancers. Here, we investigated the association of two CD86 polymorphisms, +1057G/
Honggang, Xiang +10 more
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Journal of Autoimmunity, 2006
Feeding myelin oligodendrocyte glycoprotein (MOG) followed by immunization results in induction of oral tolerance evidenced by the amelioration of experimental autoimmune encephalomyelitis (EAE). Oral tolerization is characterized by the suppression of Th1 responses and up-regulation of Th2 responses and TGF-beta.
Patricia A, Gonnella +3 more
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Feeding myelin oligodendrocyte glycoprotein (MOG) followed by immunization results in induction of oral tolerance evidenced by the amelioration of experimental autoimmune encephalomyelitis (EAE). Oral tolerization is characterized by the suppression of Th1 responses and up-regulation of Th2 responses and TGF-beta.
Patricia A, Gonnella +3 more
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Identification of an Alternatively Spliced Variant of Human CD86 mRNA
Biochemical and Biophysical Research Communications, 2001CD86 is a costimulatory molecule constitutively expressed by human antigen presenting cells which interacts with CD28 and CTLA-4 expressed by T cells. We have recently reported the identification of an alternatively spliced CD86 mRNA variant (CD86deltaTM) characterized by the deletion of exon 6 which encodes for the transmembrane domain. We report here
G, Magistrelli +5 more
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CD28/CTLA-4 and CD80/CD86 families
Immunologic Research, 1999T cell stimulation in the absence of a second, costimulatory signal can lead to anergy or the induction of cell death. CD28 is a major T cell costimulatory receptor, the coengagement of which can prevent anergy and cell death. The CD28 receptor is a member of a complex family of polypeptides that includes at least two receptors and two ligands ...
J M, Slavik +2 more
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Costimulatory molecules CD80 and CD86 in human crescentic glomerulonephritis
American Journal of Kidney Diseases, 2003CD80 and CD86, cell-surface molecules found only on antigen-presenting cells (APCs), are required for activation of CD4-postitve (CD4+) T cells by interaction with CD28/cytotoxic T-lymphocyte-associated antigen 4 on T cells. The roles of these molecules in human glomerulonephritis (GN) presently are unknown.Twelve cases of crescentic GN, thought to be ...
Qiong, Wu +3 more
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