Results 81 to 90 of about 124,972 (317)

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Temporal characterization of microglia/macrophage phenotypes in a mouse model of neonatal hypoxic-ischemic brain injury

Frontiers in Cellular Neuroscience, 2016
Immune cells display a high degree of phenotypic plasticity, which may facilitate their participation in both the progression and resolution of injury-induced inflammation.
Nina Hellström Erkenstam, Peter L.P. Smith, Bobbi Fleiss, Syam Nair, Pernilla Svedin, Wei Wang, Martina Boström, Pierre Gressens, Henrik Hagberg, Kelly L Brown, Karin Sävman, Carina Mallard   +11 more
doaj   +1 more source

The Association Between CTLA-4, CD80/86, and CD28 Gene Polymorphisms and Rheumatoid Arthritis: An Original Study and Meta-Analysis

Frontiers in Medicine, 2021
Background: Rheumatoid arthritis (RA) is related to several pivotal susceptibility genes, including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes. Although the connection between polymorphisms of CTLA-4
Weixi Liu, Zhicheng Yang, Yan Chen, Haoyu Yang, Xiaoxian Wan, Xindie Zhou, Ruiping Liu, Yunkun Zhang   +7 more
doaj   +1 more source

Characterisation of the immune-related transcriptome in resected biliary tract cancers [PDF]

, 2017
Although biliary tract cancers (BTCs) are known to have an inflammatory component, a detailed characterisation of immune-related transcripts has never been performed.
Braconi, Chiara, Carotenuto, Pietro, Cascione, Luciano, Cillo, Umberto, Fassan, Matteo, Ghidini, Michele, Hahne, Jens C., Lampis, Andrea, Mescoli, Claudia, Previdi, Maria Chiara, Raj, Maya, Rimassa, Lorenza, Roncalli, Massimo, Rugge, Massimo, Said-Huntingford, Ian, Santoro, Armando, Torzilli, Guido, Trevisani, Francesco, Valeri, Nicola, Zerbi, Alessandro   +19 more
core   +3 more sources

T-cell responses against CD19+ pediatric acute lymphoblastic leukemia mediated by bispecific T-cell engager (BiTE) are regulated contrarily by PD-L1 and CD80/CD86 on leukemic blasts

OncoTarget, 2016
T-cell immunotherapies are promising options in relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL). We investigated the effect of co-signaling molecules on T-cell attack against leukemia mediated by CD19/CD3-bispecific T-cell engager ...
J. Feucht, S. Kayser, D. Gorodezki, Mohamad Hamieh, M. Döring, Franziska Blaeschke, P. Schlegel, H. Bösmüller, L. Quintanilla-Fend, M. Ebinger, P. Lang, R. Handgretinger, T. Feuchtinger   +12 more
semanticscholar   +1 more source

Soluble CD86 protein in serum samples of patients with asthma [PDF]

Thorax, 2004
Previous studies have reported that soluble (s) CD86 is involved in the initiation of the immune response. A study was undertaken to investigate the concentrations of sCD86 in serum samples from patients with bronchial asthma and to determine the cell origin of sCD86.Serum sCD86 concentrations were measured in 52 asthmatic subjects and 25 non-atopic ...
H-Z, Shi, Z-F, Xie, J-M, Deng, Y-Q, Chen, C-Q, Xiao   +4 more
openaire   +2 more sources

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

Expression of costimulatory molecules in the bovine corpus luteum

Reproductive Biology and Endocrinology, 2007
Background Bovine luteal parenchymal cells express class II major histocompatibility complex (MHC) molecules and stimulate class II MHC-dependent activation of T cells in vitro. The ability of a class II MHC-expressing cell type to elicit a response from
Pate Joy L, Davis John S, Cannon Matthew J   +2 more
doaj   +1 more source

CD86+/CD206+, Diametrically Polarized Tumor-Associated Macrophages, Predict Hepatocellular Carcinoma Patient Prognosis

International Journal of Molecular Sciences, 2016
Tumor-associated macrophages (TAMs), the most abundant infiltrating immune cells in tumor microenvironment, have distinct functions in hepatocellular carcinoma (HCC) progression. CD68+ TAMs represent multiple polarized immune cells mainly containing CD86+
P. Dong, Lijie Ma, Longzi Liu, Guangxi Zhao, Si Zhang, Ling Dong, Ruyi Xue, She Chen   +7 more
semanticscholar   +1 more source